Results 121 to 130 of about 123,936 (336)

Prospective evaluation of low-dose ketoconazole plus hydrocortisone in docetaxel pre-treated castration-resistant prostate cancer patients. [PDF]

open access: yes, 2015
BackgroundKetoconazole is a well-known CYP17-targeted systemic treatment for castration-resistant prostate cancer (CRPC). However, most of the published data has been in the pre-chemotherapy setting; its efficacy in the post-chemotherapy setting has not ...
Beckett, LA   +6 more
core  

Microfluidic Fabrication of Hydrocortisone Nanocrystals Coated with Polymeric Stabilisers

open access: yesMicromachines, 2016
Hydrocortisone (HC) nanocrystals intended for parenteral administration of HC were produced by anti-solvent crystallisation within coaxial assemblies of pulled borosilicate glass capillaries using either co-current flow of aqueous and organic phases or ...
David F. Odetade   +1 more
doaj   +1 more source

ETV2 Overexpression Promotes Efficient Differentiation of Pluripotent Stem Cells to Endothelial Cells

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Differentiating endothelial cells (ECs) from human pluripotent stem cells (hPSCs) typically takes 2 weeks and requires parameter optimization. Overexpression of cell type‐specific transcription factors in hPSCs has shown efficient differentiation into various cell types.
Yunfeng Ding   +7 more
wiley   +1 more source

A quantitative modeling framework to understand the physiology of the hypothalamic-pituitary-adrenal axis and interaction with cortisol replacement therapy [PDF]

open access: yes
Congenital adrenal hyperplasia (CAH) is characterized by impaired adrenal cortisol production. Hydrocortisone (synthetic cortisol) is the drug-of-choice for cortisol replacement therapy, aiming to mimic physiological cortisol circadian rhythm.
Aulin, Linda B. S.   +9 more
core   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

open access: yesBMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu   +7 more
wiley   +1 more source

The Effect of Intravenous Hydrocortisone (1 or 2 mg/kg) on Postoperative Shivering in Cesarean Section with Spinal Anesthesia

open access: yesمجله دانشکده پزشکی اصفهان, 2017
Background: Postoperative shivering is one of the most prevalent complications that several methods were used for controlling it. This study aimed to determine the effect of two doses of intravenous hydrocortisone (1 or 2 mg/kg) on postoperative ...
Azim Honarmand   +3 more
doaj  

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

open access: yesBMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah   +9 more
wiley   +1 more source

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