Results 141 to 150 of about 123,936 (336)

GDF15 Analogues Acting as GFRAL Ligands

open access: yesChemMedChem, EarlyView.
Considering the great importance of the GDF15/GRAL/RET signalling pathway, this review focuses on GDF15‐derived analogues able to act either as GFRAL agonists or antagonists, investigating their possible pharmacological applications in the treatment of GDF15‐related conditions, such as obesity and diabetes (agonist), or cancer‐induced nausea and ...
Andrea Di Santo   +8 more
wiley   +1 more source

Night‐Time Chronotherapy with Methylprednisolone Prevents an Acute Rejection in Pediatric Patients with Liver Transplantation: A Randomized Clinical Trial

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Concept of methylprednisolone chronotherapy to prevent acute rejections. While endogenous cortisol secretion rises in the early morning, the number of lymphocytes in the blood is higher at night, thus exhibiting an antiphase pattern to cortisol secretion. Therefore, compared with the daytime, the infiltration of lymphocytes into immune‐reactive tissues
Kentaro Ushijima   +11 more
wiley   +1 more source

Prevention of Lung Complications following Paraquat Poisoning by Silymarin, N-acetyl Cysteine and Hydrocortisone: An Experimental Study

open access: yesIranian Journal of Toxicology, 2020
Background: Paraquat poisoning results in multi-organ failure, primarily pulmonary fibrosis, acute renal failure, and hepatic impairment. The present study was designed to evaluate three treatment regimens, such as N-Acetyl cysteine (NAC), silymarin and ...
Mohammad Jamalian   +4 more
doaj  

Methodology of high‐dimensional flow cytometry in monitoring immune microenvironment of pituitary neuroendocrine tumors

open access: yesCytometry Part B: Clinical Cytometry, EarlyView.
Abstract Characterization of the tumor immune microenvironment (TIME) of pituitary neuroendocrine tumors (PitNETs) is crucial for understanding the behavior of different types of PitNETs and identification of possible causes of their aggressiveness, rapid growth, and resistance to therapy.
Marina Yu Loguinova   +13 more
wiley   +1 more source

Concomitant arginine-vasopressin and hydrocortisone therapy in severe septic shock: association with mortality [PDF]

open access: yes, 2018
Purpose: To evaluate the association between concomitant arginine-vasopressin (AVP)/hydrocortisone therapy and mortality in severe septic shock patients.
Dünser, Martin   +6 more
core  

THE FATE OF HYDROCORTISONE-4-C14 IN MAN 1 [PDF]

open access: bronze, 1954
LEON HELLMAN   +5 more
openalex   +1 more source

Identification of human metabolites of fast skeletal troponin activators Tirasemtiv and Reldesemtiv for doping control purposes

open access: yesDrug Testing and Analysis, EarlyView.
The metabolism and urinary elimination of two substances recently classified as prohibited substances in sport was conducted, yielding suitable target analytes for efficient doping controls employing routinely applied chromatographic‐mass spectrometric test methods.
Luisa Euler   +4 more
wiley   +1 more source

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