Results 161 to 170 of about 103,469 (251)

Tolerability of Adjuvant Nivolumab in Esophageal or Gastroesophageal Junction Cancer: A Real‐World Study

International Journal of Cancer, EarlyView.
ABSTRACT Adjuvant nivolumab is approved for esophageal or gastroesophageal junction cancer after neoadjuvant chemoradiotherapy and resection. In the CheckMate‐577 trial, Grade 3–5 nivolumab‐related adverse events (AEs) occurred in 5% of patients, with early discontinuation due to toxicity in 9%. However, real‐world data on immunotherapy‐related adverse
Michelle Koops van ’t Jagt, Anniek Strijdhorst, Tamara Jessica Huizer, Esther Albertien Kleibeuker, Sarah Derks, Bianca Mostert, Hanneke van Laarhoven, Jacco Juri de Haan   +7 more
wiley   +1 more source

Cross‐Regulation Between DNA Methylation and Circadian Clock Reprogramming in Ovarian Cancer: Mechanistic Insights, Biomarker Potential, and Therapeutic Implications

International Journal of Cancer, EarlyView.
ABSTRACT Early diagnosis remains challenging, recurrence rates remain high, and platinum resistance frequently develops in ovarian cancer (OC), collectively representing major barriers to long‐term patient survival. DNA methylation (DNAm), as a relatively stable yet dynamically modifiable epigenetic signature, can capture alterations in tumor states ...
Min Xing, Chang Zhou, Yi Tang, Shuhui Xu, Shasha Zhou, Weiai Liu, Huiping Liu   +6 more
wiley   +1 more source

Modified-release hydrocortisone (Efmody^®) in children with congenital adrenal hyperplasia: a retrospective registry study. [PDF]

Front Endocrinol (Lausanne)
Lankes E, Wiebelt L, Helge KB, Schnabel D, Kühnen P, Blankenstein O, Neumann U.   +6 more
europepmc   +1 more source

Maternal overweight and obesity during pregnancy and sex‐dependent dysregulation of the materno‐fetal stress axis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Maternal obesity and excess gestational weight gain (GWG) are linked to adverse perinatal outcomes, potentially via disruption of the maternal–fetal stress axis. Placental HSD11B2 protects the fetus from excess glucocorticoids and may influence fetal programming during maternal metabolic stress.
Thorsten Braun, Marie Hofmann, Rebecca Rancourt, Julia Sommer, Alexandra Kühn, Loreen Ehrlich, Thomas Ziska, Kerstin Melchior, Karen Schellong, Wolfgang Henrich, Sonja Entringer, Katherine Margaret Kennedy, Andreas Plagemann, Deborah Magdalena Sloboda   +13 more
wiley   +1 more source

Severity of maternal anemia and the risk of giving birth to a small vulnerable newborn: A cohort analysis of the WOMAN‐2 trial in four countries

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To investigate the association between maternal hemoglobin concentration and the risk of birth to a small vulnerable newborn (SVN). Methods We conducted a cohort analysis of women with moderate or severe anemia enrolled in the World Maternal Antifibrinolytic Trial‐2 (WOMAN‐2) across Nigeria, Pakistan, Tanzania, and Zambia (August ...
Henry Ochola, Ian Roberts, Emily L. Webb, Judith Lieber, Joy E. Lawn, Hannah Blencowe, Rizwana Chaudhri, Aasia Kayani, Kiran Javaid, Oladapo Olayemi, Folasade A. Bello, Projestine Muganyizi, Mwansa Ketty Lubeya, Bellington Vwalika, Haleema Shakur‐Still, Eni Balogun, Danielle Prowse, Amy Brenner, on behalf of the WOMAN‐2 Trial Collaborators, Aziz‐un‐Nisa Abbasi, Ruqqia Sultana, Shehla Noor, Ansa Islam, Sadia Bibi, Sundus Khan, Wajeeha Khurshid, Shahida Husain Tarar, Rizwana Khalid, Aasia Kayani, Naheed Fatima, Bushra Sher Zaman, Sohail Mahmood Chaudhry, Shakila Yasmin, Khiaynat Sarwar Hashmi, Nadia Babar, Shagufta Saeed Sial, Humera Noreen, Naila Ehsan, Aisha Siddiqa, Uzma Suhail Afridi, Nosheen Sikandar, Rehana Kamaal, Najma Ghaffar, Rakhshanda Mushtaq, Safa Bibi, Shahida Magsi, Fouzia Kashif, Shaista Hifaz Abro, Javeria Abro, Fouzia Perveen, Nusrat Shah Kamal, Riffat Jaleel, Sarah Kazi, Aruna Hira, Pushpa Makhija, Naila Israr, Rizwana Chaudhri, Humaira Bilqis, Nabeela Waheed, Khansa Iqbal, Arif Tajammul, Alia Bashir, Farah Siddique, Haleema Yasmin, Khadija Bano, Saba Khan, Mubashra Samina, Sana Ishfaque, Syeda Batool Mazhar, Nasira Tasnim, Saera Afghan, Mussarat Batool, Sobia Luqman, Shehla Baqai, Asifa Siraj, Huma Quddusi, Hajira Masood, Syeda Ali, Asma Akhter, Mehnaz Khakwani, Rashida Perveen, Shahid Irshad Rao, Uzma Shaheen, Rubina Sohail, Shehla Kanwal, Tayyiba Wasim, Natasha Rasool, Shamsa Humayun, Zohra Khanum, Noreen Akmal, Shamila Ijaz Munir, Sofa Manzoor, Khola Yousaf, Misbah Kausar, Yasmeen Waqas, Oladipo Aremu, Kehinde Ogundairo, Mojisola Mobolaji‐Ojibara, Michael Babalola, Owa Olorunfemi Oludele, Iman Usman, Oyewole Tunde Aremu, Enid Simon Chiwanga, Lazaro Y. Madeha, France John Rwegoshora, Delfna Mkenda, Francis Ngimwichi Joseph, Evelyne Ludovick, Vincent Tarimo, Alfred Secha, Luzango Maembe, Julius Nyambarino, Mwansa Ketty Lubeya, Kenneth Chanda, Bellington Vwalika   +114 more
wiley   +1 more source

<i>Biomphalaria glabrata</i> as a possible experimental model for investigating anti-inflammatory substances. [PDF]

Biochem Biophys Rep
Gomes KNF, Comaru JLF, Rocha L, Faria RX.   +3 more
europepmc   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Steroid, thiamine, and ascorbic acid for comatose out-of-hospital cardiac arrest survivors (STAR): a randomised, placebo-controlled, phase 2 trial. [PDF]

EClinicalMedicine
Kim YJ, Ko BS, Roh YI, Kwon HJ, Kim S, Cha KC, Kim YH, Kim WY.   +7 more
europepmc   +1 more source

Bidirectional Pathological Axis Between Alzheimer's Disease and Circadian Rhythm Disturbance: Mechanisms and Therapeutic Strategies

iNew Medicine, EarlyView.
This graphical abstract illustrates a bidirectional vicious cycle between Alzheimer’s disease (AD) and circadian rhythm disturbance (CRD). On the one hand, AD pathology, including amyloid‐β (Aβ) plaque deposition and tau hyperphosphorylation, may damage the suprachiasmatic nucleus (SCN) and disrupt melatonin signaling, leading to sleep fragmentation ...
Jiajia Qin, Xianfeng Yu, Yayu Wang, Xiaohan Song, Yuehua Wang, Zhixin Wang, Wei Miao, Xudong Yang, Jiajia Zhu, Xiaoqun Zhu, Maria‐Trinidad Herrero   +10 more
wiley   +1 more source

Adolescent‐Dog Relationship Quality and Coping With Peer Stress

Journal of Adolescence, EarlyView.
ABSTRACT Introduction Adolescence is a developmental period involving social and peer transitions, and within this context peer stress can contribute to social anxiety. Fostering adaptive coping strategies for youth to effectively manage this peer stress is crucial for developing resilience.
Nicole Mason, Erin K. King, Evan C. Mingo, Ramina Bebezova, Kristina Callina, Megan K. Mueller   +5 more
wiley   +1 more source