Results 171 to 180 of about 175,705 (335)

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

open access: yesBMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah   +9 more
wiley   +1 more source

Fiber‐type soft bioelectronics for wearable and implantable sensing and therapy

open access: yesBMEMat, EarlyView.
Fiber‐type soft bioelectronics are emerging as versatile platforms for wearable and implantable health monitoring and therapeutic applications. These bioelectronics use organic and inorganic matrices combined with advanced fillers, which feature high conductivity, electrochemical sensitivity, softness, and biocompatibility.
Haneul Kim   +5 more
wiley   +1 more source

In silico drug repurposing against SARS-CoV-2 using an integrative transcriptomic profiling approach: Hydrocortisone and Benzhydrocodone as potential drug candidates against COVID-19

open access: gold, 2022
SeyedehMozhdeh Mirmohammadi   +6 more
openalex   +1 more source

Synthesis, In Silico, and Biological Evaluation of Non‐Hydroxamate Benzoic Acid–Based Derivatives as Potential Histone Deacetylase Inhibitors (HDACi)

open access: yesChemistry &Biodiversity, EarlyView.
Compound A3bn exhibited strong binding affinities for HDAC2, HDAC6, and HDAC8. A3bn’s anticancer IC50 values were similar to those of SAHA. Cell death resulted from the extrinsic apoptotic pathway. Compound A3bn, a hydrophilic linker, which promotes zinc coordination, may be the cause of its increased activity across HDAC isoforms. ABSTRACT Unregulated
Nedaa A. Abd Al Rahim   +8 more
wiley   +1 more source

Expanding the Phenotype of CYFIP2‐Related Developmental Epileptic Encephalopathy: Case Report and Literature Review

open access: yesAnnals of the Child Neurology Society, EarlyView.
ABSTRACT Background Pathogenic CYFIP2 variants cause developmental and epileptic encephalopathy (DEE), characterized by early‐onset intractable epilepsy and developmental delay. The disease course has not been delineated. Codon Arg87 is a de novo mutational hotspot associated with a severe DEE phenotype via gain‐of‐function mechanisms. Currently, there
Michaela Squire   +3 more
wiley   +1 more source

Tacrolimus versus hydrocortisone in management of atopic dermatitis in children, a randomized controlled double‐blind study: New insights on TARC, CTACK, TSLP, and E‐selectin

open access: yesImmunity, Inflammation and Disease
Introduction Atopic dermatitis (AD) is a type of chronic inflammatory disorder that affects all age groups including children. AD is characterized by elevated inflammatory marker levels.
Ammena Y. Binsaleh   +12 more
doaj   +1 more source

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