Results 181 to 190 of about 175,705 (335)

The Pathway to Proof‐of‐Concept for BNC210, a Negative Allosteric Modulator of the Alpha‐7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease

Clinical Pharmacology in Drug Development, EarlyView.
Abstract BNC210 is an investigational small molecule selective negative allosteric modulator of the alpha‐7 nicotinic acetylcholine receptor (α7 nAChR). It is an anxiolytic compound with a novel mechanism of action. In a series of Phase 1 clinical trials in healthy volunteers, psychometric test batteries showed that BNC210 did not cause attention ...
Paul Rolan, Elizabeth Doolin, Dharam Paul, Julia Crossman, Michael Odontiadis, Philippe Danjou, Mark Smith, Spyros Papapetropoulos   +7 more
wiley   +1 more source

Cystatin C‐based eGFR better predicts renal vancomycin clearance than creatinine‐based eGFR in patients with allogeneic stem cell transplantation

Clinical Pharmacology &Therapeutics, EarlyView.
Knowledge of the glomerular filtration rate (GFR) is mandatory when dosing renally eliminated drugs such as vancomycin. In clinical practice, different biomarkers and various equations are used to estimate GFR (eGFR), resulting in varying estimates.
Eva‐Maria A. Wansing, Sebastian G. Wicha, Peter Bannas, Alexander Heitkamp, Adrin Dadkhah, Nicolaus M. Kröger, Isabel Molwitz, Claudia Langebrake   +7 more
wiley   +1 more source

Early Administration of Hydrocortisone Replacement After the Advent of Septic Shock

, 2014
Chrisostomos Katsenos, Anastasia N. Antonopoulou, Efterpi Apostolidou, Aikaterini Ioakeimidou, Georgia Th. Kalpakou, Metaxia Papanikolaou, Aikaterini Pistiki, Margarita Mpalla, Michael Paraschos, Maria Patrani, Maria Pratikaki, Theodoros Retsas, Athina Savva, Spyridoula D. Vassiliagkou, Alexandra Lekkou, Ioanna Dimopoulou, Christina Routsi, Konstantinos Mandragos   +17 more
openalex   +1 more source

Phonophoresis Plus Topical Nitroglycerin Versus Hydrocortisone for the Management of Plantar Fasciitis: A Randomized Controlled Trial

, 2021
Razieh Maghroori, Shiva Fakhari, Parisa Taheri   +2 more
openalex   +1 more source

Parenting Stress in Adolescent Anorexia Nervosa: Differential Stress in Mothers and Fathers During Inpatient Treatment

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder that impacts both the adolescents themselves and their parents. Parenting stress is associated with impaired mental health of parents and poorer treatment outcomes for their children.
V. Stonawski, J. Kutzner, S. Büscher, A. Hoyer, O. Kratz, S. Horndasch   +5 more
wiley   +1 more source

DSOK‐0011 Potentially Regulates Circadian Misalignment and Affects Gut Microbiota Composition in Activity‐Based Anorexia Model

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a metabolic‐psychiatric disorder characterized by severe weight loss, hypercortisolemia, and hypothalamic–pituitary–adrenal (HPA) axis activation. In this study, we investigated the effect of inhibiting cortisol regeneration via the enzyme 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) on the ...
Hiroki Kawai, Nanami Wada, Shinji Sakamoto, Kenji Miyazaki, Taro Kato, Yoshihiro Horiuchi, Hiroshi Kirii, Hoang Duy Nguyen, Kenji Hinotsu, Yoshio Ohya, Takahiro Asada, Akiyoshi Yokode, Yuko Okahisa, Haruko Miyazaki, Toshitaka Oohashi, Manabu Takaki   +15 more
wiley   +1 more source

Failure of a Local Inhibitory Action on Local Injection of the Free Alcohol of Compound F (Hydrocortisone) in Some Dermatologic Lesions*

, 1952
Leon Goldman, Herbert O'Hara E., Edward Emura, Jeanne Baskett   +3 more
openalex   +1 more source

Preliminary Evidence of the Association Between Binge Eating and Preeclampsia in Pregnant U.S. Military Active‐Duty Service Women

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objectives Binge eating is the most common disordered eating behavior among pregnant women. This study examined the association of binge‐eating frequency with the presence of a self‐reported current preeclampsia diagnosis in a sample of U.S. military active‐duty Service women. Methods Active‐duty Service women (N = 134), 20–27 weeks gestation,
Ruby Schrag, Jason M. Lavender, Autumn Mains, Stephanie Rioux, Isabel Thorstad, Zoe Sinkford, Victoria Thomas, David A. Klein, Mark Haigney, Marian Tanofsky‐Kraff, Katherine A. Thompson   +10 more
wiley   +1 more source

Effect of Hydrocortisone on the Nucleotides in Carrageenin Granuloma and Chick Embryo. [PDF]

, 1959
U. K. Virtanen, E. Kulonen, Carl Axel Wachtmeister, Susanne Refn   +3 more
openalex   +1 more source

Machine learning‐based prediction of elevated N terminal pro brain natriuretic peptide among US general population

ESC Heart Failure, Volume 12, Issue 2, Page 859-868, April 2025.
Abstract Aims Natriuretic peptide‐based pre‐heart failure screening has been proposed in recent guidelines. However, an effective strategy to identify screening targets from the general population, more than half of which are at risk for heart failure or pre‐heart failure, has not been well established.
Yuichiro Mori, Shingo Fukuma, Kyohei Yamaji, Atsushi Mizuno, Naoki Kondo, Kosuke Inoue   +5 more
wiley   +1 more source