Results 91 to 100 of about 9,109 (267)

Molecular Simulations of Polymer‐based Drug Nanocarriers: From Physical and Structural Properties to Controlled Release

Advanced Healthcare Materials, EarlyView.
Polymer‐based drug delivery systems can effectively overcome the limitations of free drugs in terms of solubility, stability, and plasma half‐life, yet their development has traditionally relied on time‐consuming trial‐and‐error approaches. This review highlights recent advances in applying molecular simulation to the design of polymer‐based drug ...
Ping Gao, Xin Jiang, Jinyu Li, Julien Nicolas, Tâp Ha‐Duong   +4 more
wiley   +1 more source

Why Do Semianalytic Models Predict Higher Scatter in the Stellar Mass–Halo Mass Relation Than Cosmological Hydrodynamic Simulations?

The Astrophysical Journal
Semianalytic models (SAMs) systematically predict higher-stellar mass scatter at a given halo mass than hydrodynamical simulations and most empirical models. Our goal is to investigate the physical origin of this scatter by exploring modifications to the
Antonio J. Porras-Valverde, John C. Forbes, Rachel S. Somerville, Adam R. H. Stevens, Kelly Holley-Bockelmann, Andreas A. Berlind, Shy Genel   +6 more
doaj   +1 more source

Hydrodynamic simulations of the KT Eridani nova super-remnant [PDF]

, 2023
M. W. Healy-Kalesh, M. J. Darnley, Michael M. Shara, Kenneth M. Lanzetta, James T. Garland, Stefan Gromoll   +5 more
openalex   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Modelling lipid systems in fluid with Lattice Boltzmann Molecular Dynamics simulations and hydrodynamics [PDF]

, 2019
Astrid F. Brandner, Štěpán Timr, Simone Melchionna, Philippe Derreumaux, Marc Baaden, Fabio Sterpone   +5 more
openalex   +1 more source

Interfacial Bioengineering of Dynamic Networks Hybrid Hydrogel for Programmed Intervention in Oral Precancerous Epithelial States

Advanced Healthcare Materials, EarlyView.
This study develops a dual‐bioinspired hydrogel, MSA@PGel (macrophage membrane‐coated and salvianolic acid B/5‐aminolevulinic acid co‐loaded liposomes embedded in a polydopamine‐based gel), that integrates macrophage membrane‐mediated active targeting and mussel‐inspired wet adhesion for programmed intervention in oral precancerous lesions.
Xiaoxian Zhao, Ao Zheng, Zhengyan Zhao, Qilin Li, Tianhao Wan, Tanjun Deng, Ying Zhang, Lingyan Cao, Lan Wu   +8 more
wiley   +1 more source

Numerical Simulation of Photospheric Emission in Long Gamma-Ray Bursts: Prompt Correlations, Spectral Shapes, and Polarizations

The Astrophysical Journal
We explore the properties of photospheric emission in the context of long gamma-ray bursts (GRBs) using three numerical models that combine relativistic hydrodynamical simulations and Monte Carlo radiation transfer calculations in three dimensions.
Hirotaka Ito, Jin Matsumoto, Shigehiro Nagataki, Donald C. Warren, Maxim V. Barkov, Daisuke Yonetoku   +5 more
doaj   +1 more source

A Study on Smoothed Particle Hydrodynamics for Liquid Metal Flow Simulation [PDF]

, 2019
Jabir Al Salami, Changhong Hu, Kazuaki Hanada   +2 more
openalex   +1 more source

Dual‐Functional Polyphosphoesters for Gene Delivery: Synergistic Effects of Guanidinium and Hydrophobic Side Chains in Degradable Polymers

Advanced Healthcare Materials, EarlyView.
This study presents guanidinium‐ and indole‐functionalized polyphosphoesters as degradable, non‐viral gene delivery vectors. Through precise tuning of charge density and hydrophobicity, these polymers form stable polyplexes with low toxicity. Remarkably, minor structural changes yield up to 200‐fold differences in transfection efficiency, highlighting ...
Markus Kötzsche, Andreas Dzierza, Jan Egger, Timo Rheinberger, Christin Weilandt, Frederik R. Wurm, Ivo Nischang, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source

3D hydrodynamic simulations of massive main-sequence stars – II. Convective excitation and spectra of internal gravity waves [PDF]

William Thompson, Falk Herwig, Paul R. Woodward, Huaqing Mao, Pavel A. Denissenkov, D. M. Bowman, Simon Blouin   +6 more
openalex   +1 more source