Results 261 to 270 of about 6,989 (307)

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment

Advanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang   +12 more
wiley   +1 more source

Red Blood Cells as Endogenous Biotweezers for Optical Micromanipulation In Vivo

Advanced Science, EarlyView.
By synergistically integrating the long‐distance manipulation fiber probe (LDMFP) and endogenous red blood cells (RBCs) as biocompatible optical elements, a natural RBC biotweezer was developed for the desired microparticle manipulation and immune cell activation within living vasculature, which might offer an alternative tool for intravital optical ...
Tong Yang, Xinyu Ren, Dalin Ma, Hao Pang, Wei Chen, Kaize Cai, Mei Yuan, Bingzhi Zhang, Zufang Lin, Xiaoshuai Liu   +9 more
wiley   +1 more source

Multiscale Perspectives on Solid-Phase Astrochemistry: Laboratory, Computation, and Open Questions. [PDF]

Space Sci Rev
Dickers MD, Mifsud DV, Mason NJ, Fantuzzi F.   +3 more
europepmc   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

A comprehensive study on changes in coastal hydrodynamics associated with cyclonic activity. [PDF]

Sci Rep
Salama NM, Tonbol KM, ElKut A, ElBessa M, Kotroni V.   +4 more
europepmc   +1 more source

The Knudsen Layer in the Heat Transport Beyond the Fourier Law: Application to the Wave Propagation at Nanoscale. [PDF]

Entropy (Basel)
Carlomagno I, Sellitto A.
europepmc   +1 more source

Measurements of the hydrodynamic pressure on a surfboard fin during surfing. [PDF]

Sci Rep
Kniesburges S, Punger N, Tur B, Zöllner M, In Het Panhuis M, Döllinger M.   +5 more
europepmc   +1 more source

Extended hot dust emission around the earliest massive quiescent galaxy

Ji Z, Williams C, Rieke G, Lyu J, Alberts S, Sun F, Helton J, Rieke M, Shivaei I, D'Eugenio F, Tacchella S, Robertson B, Zhu Y, Maiolino R, Bunker A, Sun Y, Willmer C.   +16 more
europepmc   +1 more source

Theory of multiscale epithelial mechanics under stretch: from active gels to vertex models

Ouzeri A, Kale S, Chahare N, Torres-Sanchez A, Santos-Olivan D, Trepat X, Arroyo M.   +6 more
europepmc   +1 more source