Results 91 to 100 of about 106,820 (243)

Endosomal Escape of siRNA Polyplexes: A Molecular Dynamics Perspective on Underlying Mechanisms

Advanced Functional Materials, EarlyView.
Molecular dynamics simulations reveal distinct endosomal escape mechanisms of siRNA nanoparticles, ranging from electrostatic membrane attachment to hydrophobic membrane fusion. Hydrophobic residues and anionic endosomal lipids emerge as key determinants of membrane disruption, linking molecular interactions to experimental delivery performance and ...
Katharina M. Steinegger, Min Jiang, Florian Belger, Fabian Link, Benjamin Winkeljann, Olivia M. Merkel   +5 more
wiley   +1 more source

Towards effects from stent implantation into coronary bifurcation stenosis: experiment and simulation

Сибирский научный медицинский журнал
Coronary artery disease is a widespread cause of death and disability in the population. Angioplasty of the coronary arteries is one of the most common methods of eliminating the cause of ischemia – stenosis of the coronary arteries. As a result of stent
R. A. Gaifutdinov, Yu. O. Kuyanova, D. A. Khelimsky, O. V. Krestyaninov, A. A. Tulupov, D. V. Parshin   +5 more
doaj   +1 more source

Microfluidic Engineering of Microgels: A Review of Emerging Technologies, Materials, Fabrication Strategies, and Applications

Advanced Healthcare Materials, EarlyView.
Recent advances in microfluidic technologies for microgel fabrication are critically reviewed, highlighting the capabilities and limitations of major microfluidic platforms and discussing how platform design, material selection, and crosslinking strategies influence microgel architecture and functionality. Current challenges and future opportunities in
Afshin Abrishamkar, Laura Neely, Cynthia Pham, Nada Ibrahim, Alexis Larios‐Cervantes, Ben A. Kertesz, Todd Hoare   +6 more
wiley   +1 more source

Experimental Investigation on IceBreaking Resistance and Ice Load Distribution for Comparison of Icebreaker Bows

Journal of Marine Science and Engineering
During icebreaker navigation in ice-covered waters, icebreaking resistance and dynamic ice loads acting on the bow critically determine the vessel’s icebreaking performance.
Xuhao Gang, Yukui Tian, Chaoge Yu, Ying Kou, Weihang Zhao   +4 more
doaj   +1 more source

Simulation of Polymer Flow Using Smoothed Particle Hydrodynamics Method [PDF]

, 2013
Reactive rotational molding (RRM) is a process to manufacture hollow plastic articles. Comparing to rotational molding of thermoplastics, it decreases the process cycle time due to the reactivity of the system.
FARZANEH, Sedigheh, BAKIR, Farid, TCHARKHTCHI, Abbas, S. Riviere, F. Bakir, S. Khelladi, A. Tcharkhtchi, KHELLADI, Sofiane, S. Farzaneh, FARZANEH, Sedigeh, RIVIERE, Sylvain   +10 more
core   +1 more source

Protein‐Polymer Dynamic Hydrogels Utilizing Native Ligand Binding for Injectable Therapeutic Delivery and 3D Printing

Advanced Healthcare Materials, EarlyView.
Dynamic nanocolloidal hydrogels were synthesized via the co‐assembly of ligand‐modified spheroidal hyperbranched poly(glycerol) (HPG) and soluble albumin nanoparticles (SANs). Co‐assembly occurred through self‐association of the HPG, as well as its interaction with SANs via native ligand binding.
S. Cem Millik, Yonghui Wang, Kefan Song, Jessica M. Snyder, LeAnn Le, Lauren G. Brown, Shanny Hsuan Kuo, Ashleigh B. Theberge, Suzie H. Pun, Alshakim Nelson   +9 more
wiley   +1 more source

Rational Control of Antibody Orientation for Enhancing Sensitivity and Specificity in Lateral Flow Immunoassays With Clinical Validation

Advanced Healthcare Materials, EarlyView.
Systematic investigation of antibody orientation strategies in lateral flow immunoassays reveals that a para‐substituted (aminomethyl)phenylboronic acid mediated probe (P‐6) combined with a biotin‐streptavidin test‐line modification achieves a synergistic 14‐ to 19‐fold sensitivity gain over conventional conjugation. Furthermore, multiplexed detection,
Pin‐Hao Wang, Shunmuga Nathan Shunmuga Nainar, Bing‐Han Zhuang, Shun‐Mao Yang, Hong‐Cheu Lin, Yang‐Hsiang Chan   +5 more
wiley   +1 more source

Recent Advances in the Analysis of Macromolecular Interactions Using the Matrix-Free Method of Sedimentation in the Analytical Ultracentrifuge

Biology, 2015
Sedimentation in the analytical ultracentrifuge is a matrix free solution technique with no immobilisation, columns, or membranes required and can be used to study self-association and complex or “hetero”-interactions, stoichiometry, reversibility and ...
Stephen E. Harding, Richard B. Gillis, Fahad Almutairi, Tayyibe Erten, M. Şamil Kök, Gary G. Adams   +5 more
doaj   +1 more source

Anti‐Inflammatory and Neuroactive Effects of Polymer‐Coated Iron Oxide Nanoparticles Functionalized With Interleukin 4 for Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
Polymer‐coated IONPs functionalized with IL‐4 display respective neuroactive and anti‐inflammatory actions on neural progenitor cells and macrophages/microglia in vitro. When examined chronically in a rat experimental model of spinal cord injury, rGO scaffolds carrying these nanosystems adequately integrate into the lesion, significantly reduce ...
Julia Martínez‐Ramírez, Paloma Lozano‐Picazo, María de Lamo‐Atencia, Andrea Ferreras, Esther Benayas‐Martín, Elena Fernández‐López, Marina Sánchez‐Petidier, Verónica Barranco‐Maresca, Víctor Caz, Anne des Rieux, Juliana M. Rosa, María del Puerto Morales, María C. Serrano   +12 more
wiley   +1 more source

Assessment of evapotranspiration simulations in the Malše basin

Soil and Water Research, 2009
The application of the distributed hydrological model brings the benefits of assessment of the spatially distributed quantities which are hard to measure in the field over a larger area, e.g. evapotranspiration.
Romana KOŠKOVÁ, Soňa NĚMEČKOVÁ
doaj   +1 more source