Results 21 to 30 of about 236,695 (247)

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

FEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti, Sebastian Obermaier, Dirk J. Slotboom, Bert Poolman   +3 more
wiley   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Free Radical Generation From Hydrazine Decomposition Catalyzed by Pt/SiO2 in Different Acid-Base Systems

He huaxue yu fangshe huaxue
Electron spin resonance spectroscopy(ESR) was used to investigate the effects of hydrogen ion concentration and hydroxide concentration in perchloric acid system and sodium hydroxide system on the state and behavior of free radicals generated by ...
LI Bin, HAO Shuai, ZHANG Qiu-yue, XIA Liang-shu, HE Hui   +4 more
doaj   +1 more source

Antigingivitis, Desensitizing, and Antiplaque Effects of Alkaline Toothpastes: A Randomized Clinical Trial

Dentistry Journal, 2023
Gingivitis is a widespread disease commonly associated with dentin hypersensitivity, that, in turn, may complicate routine dental care, leading to plaque accumulation.
Nina Novozhilova, Elena Andreeva, Maria Polyakova, Irina Makeeva, Inna Sokhova, Vladlena Doroshina, Alexandr Zaytsev, Ksenia Babina   +7 more
doaj   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Generation of quasi-monoenergetic protons from thin multi-ion foils by a combination of laser radiation pressure acceleration and shielded Coulomb repulsion

New Journal of Physics, 2013
We study theoretically and numerically the acceleration of protons by a combination of laser radiation pressure acceleration and Coulomb repulsion of carbon ions in a multi-ion thin foil made of carbon and hydrogen.
Tung-Chang Liu, Xi Shao, Chuan-Sheng Liu, Minqing He, Bengt Eliasson, Vipin Tripathi, Jao-Jang Su, Jyhpyng Wang, Shih-Hung Chen   +8 more
doaj   +1 more source

Enhanced discovery of bacterial laccase‐like multicopper oxidase through computer simulation and metagenomic analysis of industrial wastewater

FEBS Open Bio, EarlyView.
We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui, Ariel Kushmaro, Hana Barak, Anja Poehlein, Rolf Daniel, Hans‐Jürgen Mägert   +5 more
wiley   +1 more source

Water sorption and solubility of glass ionomer cements indicated for atraumatic restorative treatment considering the time and the pH of the storage solution

RGO: Revista Gaúcha de Odontologia, 2018
Objective: Evaluate the water sorption and the solubility of glass ionomer cements considering the time and the pH of the storage solution. Methods: The materials used in this survey study were the following ones: Ketac Molar Easymix, Maxxion R, Vitro ...
Renally Bezerra Wanderley e LIMA, Julyanna Filgueiras Gonçalves de FARIAS, Ana Karina Maciel ANDRADE, Fábia Danielle Sales da Cunha Medeiros e SILVA, Rosângela Marques DUARTE   +4 more
doaj   +1 more source

The pH of the main Brazilian commercial moisturizers and liquid soaps: considerations on the repair of the skin barrier [PDF]

Anais Brasileiros de Dermatologia, 2017
: The pH of the skin is slightly acidic (4.6 to 5.8) which is important for appropriate antibacterial, antifungal, constitution of barrier function, as well as structuring and maturation of the stratum corneum.
Giovana M Gonçalves, Gabrielli Brianezi, Hélio Amante Miot   +2 more
doaj   +2 more sources

Boundaries of photosynthesis: adaptations of carbon fixation in extreme environments

FEBS Open Bio, EarlyView.
Photosynthesis faces challenges from environmental extremes of temperature, pH, and salinity, limiting gas diffusion, modifying membrane fluidity, and destabilizing photochemical and biochemical reactions. Photosynthetic organisms have evolved unique adaptations overcoming these stresses and maintaining their photosynthetic activity.
Pere Aguiló‐Nicolau, Concepción Iñiguez, Sebastià Capó‐Bauçà, Jeroni Galmés   +3 more
wiley   +1 more source