Results 61 to 70 of about 3,613,864 (336)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Surface evolution during crystalline silicon film growth by low-temperature hot-wire chemical vapor deposition on silicon substrates [PDF]

, 2006
We investigate the low-temperature growth of crystalline thin silicon films: epitaxial, twinned, and polycrystalline, by hot-wire chemical vapor deposition (HWCVD).
Atwater, Harry A., Park, Young-Bae, Richardson, Christine Esber   +2 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Experimental Study and Development of Design Formula for Estimating the Ultimate Strength of Curved Plates

Applied Sciences, 2021
The curved plate has been extensively used as a structural member in many industrial fields, especially the shipbuilding industry. The present study investigated the ultimate strength and collapse behavior of the simply supported curved plate under a ...
Jeong-Hyeon Kim, Doo-Hwan Park, Seul-Kee Kim, Myung-Sung Kim, Jae-Myung Lee   +4 more
doaj   +1 more source

Study to minimize hydrogen embrittlement of ultrahigh-strength steels [PDF]

, 1967
Hydrogen-stress cracking in high-strength steels is influenced by hydrogen content of the material and its hydrogen absorption tendency. Non-embrittling cleaning, pickling, and electroplating processes are being studied.
Elsea, S. T., Fletcher, E. E., Groeneveld, T. P.   +2 more
core   +1 more source

Theory of the 2S-2P Lamb shift and 2S hyperfine splitting in muonic hydrogen

, 2012
The 7 standard deviations between the proton rms charge radius from muonic hydrogen and the CODATA-10 value from hydrogen spectroscopy and electron-scattering has caused considerable discussions.
Adamczak, Adamuscin, Adamuscin, Aldo Antognini, Anthony, Antognini, Antognini, Arnoult, Arrington, Barbieri, Barger, Barger, Batell, Bernauer, Biraben, Birse, Blunden, Borie, Borie, Borie, Brax, Brodsky, Carlson, Carlson, Carlson, Carlson, Carroll, Cherednikova, Chu, Cloet, Collins, Danzmann, de Beauvoir, De Rújula, De Rújula, Distler, Eides, Eides, Eides, Eides, Fischer, Flowers, Franz Kottmann, François Biraben, François Nez, Friar, Friar, Friar, Gilad, Hagley, Hanneke, Hasell, Hill, Hill, Hägler, Ivanov, Jaeckel, Jentschura, Jentschura, Jentschura, Jentschura, Jentschura, Karr, Karshenboim, Karshenboim, Karshenboim, Karshenboim, Karshenboim, Karshenboim, Kelly, Kinoshita, Kohl, Ledwig, Lorenz, Lundeen, Martynenko, Martynenko, Martynenko, Martynenko, Martynenko, McKeen, Miller, Mohr, Müller, Pachucki, Pachucki, Parthey, Parthey, Paul Indelicato, Petermann, Pineda, Pineda, Pohl, Pohl, Pohl, Prok, Randolf Pohl, Raue, Rivas, Romanov, Ron, Schwob, Sick, Sick, Sick, Slifer, Sturm, Suura, Tan, Tucker-Smith, Vanderhaeghen, Wesselmann, Zemach, Zhan   +113 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Highly thermally conductive composite films by the rational assembly of aramid nanofibers with low-dimensional nanofillers

Journal of Materials Research and Technology
Highly efficient thermal management of electronic devices has grown in significance with the burgeoning of semiconductor technology and 5th generation communication.
Xuyun Liang, Gaofa Chen, Qingshan Wu, Haichen Zhang, Rongjian Zhong, Xianghong Zeng, Dechao Hu, Jing Lin   +7 more
doaj   +1 more source

Hydrogen absorption properties of amorphous (Ni0.6Nb0.4−yTay)100−xZrx membranes [PDF]

, 2017
Ni based amorphous materials have great potential as hydrogen purification membranes. In the present work the melt spun (Ni0.6Nb0.4−yTay)100−xZrx with y=0, 0.1 and x=20, 30 was studied.
Chandra, D., Dolan, M., Flanagan, T., Hulyalkar, M., Pal, N., Palumbo, O., Paolone, A., Sarker, S., Trequattrini, Francesco   +8 more
core   +4 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source