Results 41 to 50 of about 112,059 (261)

Advanced applications of pulsed laser deposition in electrocatalysts for hydrogen-electric conversion systems

Opto-Electronic Advances
Pulsed laser deposition (PLD), as an advanced synthesis technology with unparalleled control over thin films, has evolved into a universal platform for optoelectronic materials engineering. Its unique advantages including precise stoichiometric transfer,
Yuanyuan Zhou, Yong Wang, Ke Zhang, Huaqian Leng, Peter Müller-Buschbaum, Nian Li, Liang Qiao   +6 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Co doped MoS2 as Bifunctional Electrocatalyst for Hydrogen Evolution and Oxygen Reduction Reactions

International Journal of Electrochemical Science, 2019
Pure MoS2 and MoS2 compounds were doped with Co using a hydrothermal method. XRD results indicate that two of the five diffraction peak results at 9.2° and 18.2° may be attributed to low crystallinity of MoS2. The (002) diffraction peaks for the Co-doped
Congrong Wang, Shun Wang, Jianguo Lv, Yuxuan Ma, Yongqi Wang, Gaoliang Zhou, Mingsheng Chen, Min Zhao, Xiaoshuang Chen, Lei Yang   +9 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Recent advances in alternative oxidation reactions for water splitting and their efficient electrocatalysts

工程科学学报
Developing state-of-the-art water electrolysis technologies to advance large-scale hydrogen production is an effective way to ease the current energy crisis and environmental pollution.
Miao WANG, Rongrong DENG, Qibo ZHANG
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Developments in Nanostructured MoS₂-Decorated Reduced Graphene Oxide Composite Aerogel as an Electrocatalyst for the Hydrogen Evolution Reaction

Gels
Developing lightweight, highly active surfaces with a high level of performance and great stability is crucial for ensuring the dependability of energy harvesting and conversion devices.
Sadhasivam Thangarasu, Mrunal Bhosale, Gowthami Palanisamy, Tae Hwan Oh   +3 more
doaj   +1 more source

1,2-Amino oxygenation of alkenes with hydrogen evolution reaction

Nature Communications, 2022
1,2-Aminoxygenation of alkenes without extra oxidant is a practical yet challenging way to prepare β-amino alcohols. Here, the authors report an electro-oxidative route achieving such a goal with H2 evolution, exhibiting broad scope and application ...
Shengzhang Liu, Shengchun Wang, Pengjie Wang, Zhiliang Huang, Tao Wang, Aiwen Lei   +5 more
doaj   +1 more source