Results 51 to 60 of about 112,375 (261)

1,2-Amino oxygenation of alkenes with hydrogen evolution reaction

Nature Communications, 2022
1,2-Aminoxygenation of alkenes without extra oxidant is a practical yet challenging way to prepare β-amino alcohols. Here, the authors report an electro-oxidative route achieving such a goal with H2 evolution, exhibiting broad scope and application ...
Shengzhang Liu, Shengchun Wang, Pengjie Wang, Zhiliang Huang, Tao Wang, Aiwen Lei   +5 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

WO3-Based Materials as Electrocatalysts for Hydrogen Evolution Reaction

Frontiers in Materials, 2020
Environmental pollution and energy shortage make the development of clean energy more and more urgent. As a kind of clean renewable energy, hydrogen has attracted more attention recently.
Yixuan Li, Xiaoliang Zhai, Yong Liu, Yong Liu, Huijie Wei, Junqing Ma, Min Chen, Xianming Liu, Wanhong Zhang, Guangxin Wang, Fengzhang Ren, Shizhong Wei, Shizhong Wei   +12 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Different electrode modification protocols for evaluating the water-splitting properties of a P(V)-metalloporphyrin [PDF]

Journal of the Serbian Chemical Society
Water electrolysis is currently a notable research domain, having the identification of highly active, stable, and low-cost electrocatalysts as one of its most important pursuits.
Taranu Bogdan-Ovidiu
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Nickel Nanoparticles Infused Iron Tungstate Nanocomposite for Clean Energy Carrier Hydrogen Generation via Water Splitting

Advanced Materials Interfaces
Green hydrogen, as a renewable energy source with vast potential and multiple uses, will play a crucial role in the energy transition. This study focuses on improving clean energy production, specifically green hydrogen, through the synthesis and ...
Dasu Ram Paudel, Rama Kafle, Niraj Dhital, Manjinder Singh, Balaji S. Salokhe   +4 more
doaj   +1 more source