Results 71 to 80 of about 5,299,592 (349)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Research Progress in Electrocatalytic Hydrogen Evolution Reaction Catalysts: From Multidimensional Nanostructures to Single Atom Regulation

Shiyou huagong gaodeng xuexiao xuebao
Electrocatalytic water splitting for hydrogen production is a crucial technological approach for renewable energy storage and utilization. Based on the hydrogen evolution reaction mechanism, this paper systematically reviews the structural evolution of ...
Jiaqing LUO, Zhenquan WANG, Tianying YU, Ningge LI, Qingfang SHI, Ruipeng ZHANG, Bohan KANG, Haipeng ZHANG, Zijie WAN   +8 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Recent advances in alternative oxidation reactions for water splitting and their efficient electrocatalysts

工程科学学报
Developing state-of-the-art water electrolysis technologies to advance large-scale hydrogen production is an effective way to ease the current energy crisis and environmental pollution.
Miao WANG, Rongrong DENG, Qibo ZHANG
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Developments in Nanostructured MoS₂-Decorated Reduced Graphene Oxide Composite Aerogel as an Electrocatalyst for the Hydrogen Evolution Reaction

Gels
Developing lightweight, highly active surfaces with a high level of performance and great stability is crucial for ensuring the dependability of energy harvesting and conversion devices.
Sadhasivam Thangarasu, Mrunal Bhosale, Gowthami Palanisamy, Tae Hwan Oh   +3 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Kinetics of Sodium Borohydride Hydrolysis Reaction for Hydrogen Generation

, 2011
In this work, a ruthenium catalyst was prepared for hydrogen generation from the hydrolysis reaction of an alkaline sodium borohydride solution. The reactions were carried out in a batch reactor at temperatures of 10, 30, 40 and 60 °C for at least 70 ...
Hung, Ai-jen; Tsai, Shing-fen; Hsu, Ya-yi; Ju, Jie-ren; Chen, Yih-hang; Yu, Cheng-ching
core   +1 more source

INJECTION OF HYDROGEN INTO HIGH PRESSURE NATURAL GAS GRIDS: INVESTIGATION OF THE IMPACT ON MATERIALS AND EQUIPMENT AT RELEVANT ENVIRONMENT

, 2022
Publisher Copyright: © 2022 Proceedings of WHEC 2022 - 23rd World Hydrogen Energy Conference: Bridging Continents by H2. All rights reserved.This work addresses the potential of hydrogen injection into the transmission high pressure natural gas grid as ...
Madina, Virginia, de Gracia, María Dolores Storch, Fernandez, Ekain, Cerezo-Alarcón, Alberto, Gil, Vanesa, Sánchez-Laínez, Javier   +5 more
core   +1 more source