Results 71 to 80 of about 441,985 (347)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Developments in Nanostructured MoS₂-Decorated Reduced Graphene Oxide Composite Aerogel as an Electrocatalyst for the Hydrogen Evolution Reaction

Gels
Developing lightweight, highly active surfaces with a high level of performance and great stability is crucial for ensuring the dependability of energy harvesting and conversion devices.
Sadhasivam Thangarasu, Mrunal Bhosale, Gowthami Palanisamy, Tae Hwan Oh   +3 more
doaj   +1 more source

WO3-Based Materials as Electrocatalysts for Hydrogen Evolution Reaction

Frontiers in Materials, 2020
Environmental pollution and energy shortage make the development of clean energy more and more urgent. As a kind of clean renewable energy, hydrogen has attracted more attention recently.
Yixuan Li, Xiaoliang Zhai, Yong Liu, Yong Liu, Huijie Wei, Junqing Ma, Min Chen, Xianming Liu, Wanhong Zhang, Guangxin Wang, Fengzhang Ren, Shizhong Wei, Shizhong Wei   +12 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Different electrode modification protocols for evaluating the water-splitting properties of a P(V)-metalloporphyrin [PDF]

Journal of the Serbian Chemical Society
Water electrolysis is currently a notable research domain, having the identification of highly active, stable, and low-cost electrocatalysts as one of its most important pursuits.
Taranu Bogdan-Ovidiu
doaj   +1 more source

Molybdenum-Tungsten carbides based electrocatalysts for hydrogen evolution reaction

International Journal of Sustainable Energy, 2023
Tungsten carbide-based nano-catalysts (Ni-WC, Co-WC and NiCo-WC) and molybdenum carbide-based nano-catalysts (Ni-MoC, Co-MoC and NiCo-MoC) were synthesised using a carbothermal reduction method.
Busisiwe Petunia Mabuea, Elizabeth Erasmus, Hendrik Christoffel Swart   +2 more
doaj   +1 more source

New Cobalt‐Bisterpyridyl Catalysts for Hydrogen Evolution Reaction [PDF]

ChemCatChem, 2017
AbstractPreparation of a series of terpyridyl ligands bearing different substituents recently led to the synthesis of new cobalt‐bisterpyridyl complexes spanning over a wide range of redox potentials. In this work, we describe the catalytic properties of these complexes for the electroreduction of protons into hydrogen (hydrogen evolution reaction (HER)
Aroua, Safwan, Todorova, Tanya K, Mougel, Victor, Hommes, Paul, Reissig, Hans, Fontecave, Marc   +5 more
openaire   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Engineering Ruthenium-Based Electrocatalysts for Effective Hydrogen Evolution Reaction

Nano-Micro Letters, 2021
The investigation of highly effective, durable, and cost-effective electrocatalysts for the hydrogen evolution reaction (HER) is a prerequisite for the upcoming hydrogen energy society.
Yingjie Yang, Yanhui Yu, Jing Li, Qingrong Chen, Yanlian Du, Peng Rao, Ruisong Li, Chunman Jia, Zhenye Kang, Peilin Deng, Yijun Shen, Xinlong Tian   +11 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source