Results 101 to 110 of about 272,012 (351)

Endopeptidase Regulation as a Novel Function of the Zur-Dependent Zinc Starvation Response

mBio, 2019
The cell wall is a strong, yet flexible, meshwork of peptidoglycan (PG) that gives a bacterium structural integrity. To accommodate a growing cell, the wall is remodeled by both PG synthesis and degradation.
Shannon G. Murphy, Laura Alvarez, Myfanwy C. Adams, Shuning Liu, Joshua S. Chappie, Felipe Cava, Tobias Dörr   +6 more
doaj   +1 more source

A Quantum Framework for Protein Binding‐Site Structure Prediction on Utility‐Level Quantum Processors

Advanced Science, EarlyView.
This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...
Yuqi Zhang, Yuxin Yang, William Martin, Kingsten Lin, Zixu Wang, Cheng‐Chang Lu, Weiwen Jiang, Ruth Nussinov, Joseph Loscalzo, Qiang Guan, Feixiong Cheng   +10 more
wiley   +1 more source

Evaluation of ubiquitin C-terminal hydrolase-L1 enzyme levels in patients with epilepsy [PDF]

, 2020
İbrahim Halil Yasak, Mustafa Yılmaz, Murat Gönen, Metin Ateşçelik, Mehtap Gürger, Nevin İlhan, Mehmet Çağrı Göktekin   +6 more
openalex   +1 more source

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source

Enzymatic diversity in the haloactinomycetes isolated from rhizosphere of the plants in saline soils at the periphery of Dasht-e-Kavir desert

یافته‌های نوین در علوم زیستی, 2022
Saline rhizospheric areas are untouched environments for isolating actinomycetes with the potential of valuable salt tolerant enzyme production. In this study, we isolated and evaluated a total number of of 26 actinomycete strains from plant rhizosphere ...
Ensieh Salehghamari
doaj  

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

Advanced Science, EarlyView.
Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel, Nikolaj M. Malmgaard‐Clausen, Marius Lendal, Hartwig R. Siebner, René B. Svensson, Stephanie G. Dakin, Marcus Krüger, Luisa Schmidt, Jakob Agergaard, Ching‐Yan Chloé Yeung, S. Peter Magnusson, Michael Kjaer   +11 more
wiley   +1 more source

Illuminating a biologics development challenge: systematic characterization of CHO cell-derived hydrolases identified in monoclonal antibody formulations

mAbs
Monoclonal antibodies (mAb) and other biological drugs are affected by enzymatic polysorbate (PS) degradation that reduces product stability and jeopardizes the supply of innovative medicines.
Melanie Maier, Linus Weiß, Nikolas Zeh, Valerie Schmieder-Todtenhaupt, Alireza Dehghani, Marius Nicolaus Felix, Daniel Heinzelmann, Benjamin Lindner, Moritz Schmidt, Joey Studts, Patrick Schulz, Bernd Reisinger, Kerstin Otte, Matthias Franzreb, Daniel Lakatos, Simon Fischer   +15 more
doaj   +1 more source

DWARF14, A Receptor Covalently Linked with the Active Form of Strigolactones, Undergoes Strigolactone-Dependent Degradation in Rice

Frontiers in Plant Science, 2017
Strigolactones (SLs) are the latest confirmed phytohormones that regulate shoot branching by inhibiting bud outgrowth in higher plants. Perception of SLs depends on a novel mechanism employing an enzyme-receptor DWARF14 (D14) that hydrolyzes SLs and ...
Qingliang Hu, Qingliang Hu, Yajun He, Yajun He, Lei Wang, Simiao Liu, Xiangbing Meng, Guifu Liu, Yanhui Jing, Mingjiang Chen, Xiaoguang Song, Liang Jiang, Hong Yu, Bing Wang, Jiayang Li, Jiayang Li   +15 more
doaj   +1 more source

Structural Variation and 3D Genome‐Driven DNA/RNA Methylation Divergence Contributing to Cotton Fiber Domestication

Advanced Science, EarlyView.
These findings elucidated the crucial role of the “SVs‐3D genome remodeling‐epigenetic modifications‐gene expression” cascade regulatory network in cotton fiber domestication, offering both a theoretical foundation and genetic resources for molecular design breeding in fiber crops.
Lei Shao, Shangkun Jin, Haojie Jiang, Tianyu Pan, Zesheng Rui, Xiaowen Shi, Ting Zhao, Zhanfeng Si, Xueying Guan, Yan Hu, Tianzhen Zhang, Lei Fang   +11 more
wiley   +1 more source

Phenolic supplements: testing an approach to limit Sphagnum decomposition in a Sphagnum farming system

Frontiers in Earth Science
Phenolic compounds have been proposed to influence decomposition by inhibiting extracellular enzyme activities, as described in the enzymic latch mechanism (ELM).
Talal Asif, Line Rochefort, Chris Freeman, Christian Dunn, Hojeong Kang, Mélina Guêné-Nanchen   +5 more
doaj   +1 more source