Results 81 to 90 of about 168,228 (310)

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Probing the Active Site of Class 3 L-Asparaginase by Mutagenesis: Mutations of the Ser-Lys Tandems of ReAV

Biomolecules
The ReAV enzyme from Rhizobium etli, a representative of Class 3 L-asparaginases, is sequentially and structurally different from other known L-asparaginases. This distinctiveness makes ReAV a candidate for novel antileukemic therapies.
Kinga Pokrywka, Marta Grzechowiak, Joanna Sliwiak, Paulina Worsztynowicz, Joanna I. Loch, Milosz Ruszkowski, Miroslaw Gilski, Mariusz Jaskolski   +7 more
doaj   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Illuminating a biologics development challenge: systematic characterization of CHO cell-derived hydrolases identified in monoclonal antibody formulations

mAbs
Monoclonal antibodies (mAb) and other biological drugs are affected by enzymatic polysorbate (PS) degradation that reduces product stability and jeopardizes the supply of innovative medicines.
Melanie Maier, Linus Weiß, Nikolas Zeh, Valerie Schmieder-Todtenhaupt, Alireza Dehghani, Marius Nicolaus Felix, Daniel Heinzelmann, Benjamin Lindner, Moritz Schmidt, Joey Studts, Patrick Schulz, Bernd Reisinger, Kerstin Otte, Matthias Franzreb, Daniel Lakatos, Simon Fischer   +15 more
doaj   +1 more source

The Nudix Hydrolase 7 is an Acyl-CoA Diphosphatase Involved in Regulating Peroxisomal Coenzyme A Homeostasis

, 2008
Coenzyme A (CoASH) is an obligate cofactor for lipids undergoing b-oxidation in peroxisomes. Although the peroxisomal membrane appears to be impermeable to CoASH, peroxisomes contain their own pool of CoASH.
Veronika Till, S.-J. Reilly, Stefan E. H. Alexson, M. C. Hunt, Sarah-jayne Reilly, Hunt, Mary C., Reilly, Sarah-Jayne, S. E.H. Alexson, Alexson, Stefan E. H., Ofman, Rob, Tillander, Veronica, Mary C. Hunt Y, R. Ofman, Rob Ofman, Tillander, Veronika, Hunt, Mary, V. Tillander, Alexson, Stefan   +17 more
core   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Phenolic supplements: testing an approach to limit Sphagnum decomposition in a Sphagnum farming system

Frontiers in Earth Science
Phenolic compounds have been proposed to influence decomposition by inhibiting extracellular enzyme activities, as described in the enzymic latch mechanism (ELM).
Talal Asif, Line Rochefort, Chris Freeman, Christian Dunn, Hojeong Kang, Mélina Guêné-Nanchen   +5 more
doaj   +1 more source

Properties of epoxide hydrolase from the yeast Rhodotorula glutinis

, 2002
Epoxide hydrolases are ubiquitous enzymes that can be found in nearly all living organisms. Some of the enzymes play an important role in detoxifying xenobiotic and metabolic compounds.
Ariës-Kronenburg, N.A.E.
core  

Cloning and characterization of the first member of the Nudix family from Arabidopsis thaliana. [PDF]

, 2002
The sequence motif commonly called a Nudix box, represented by (GX(5)EX(7)REVXEEXGU) is the marker of a widely distributed family of enzymes that catalyze the hydrolysis of a variety of nucleoside diphosphate derivatives. Here we describe the cloning and
Dobrzanska, Marta, Kraszewska, Elzbieta, Szurmak, Blanka, Wysłouch-Cieszyńska, Aleksandra   +3 more
core  

Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors

, 2017
Leukotriene A4 Hydrolase (LTA4H) is a bifunctional zinc metalloenzyme that comprises both epoxide hydrolase and aminopeptidase activity, exerted by two overlapping catalytic sites.
Penno, CA, Petra Jäger, Liz Hardaker, Claire Laguerre, Röthlisberger, P, Jäger, P, Arnaud Osmont, Houguenade, J, Shin Numao, Bergsdorf, C, Carte, N, Numao, S, Andreas Hofmann, Billich, A, Carlos A. Penno, Patrik Röthlisberger, Romain M. Wolf, Osmont, A, Hardaker, L, Andres Schmid, Jeremy Houguenade, Hasler, F, Honnappa Srinivas, Wack, N, Franziska Hasler, Hofmann, A, Miltz, W, Janet Dawson, Till A. Röhn, Andreas Billich, Birgit Bollbuck, Markert, C, Nathalie Carte, Dawson, J, Laguerre, C, Srinivas, H, Wolf, RM, Nathalie Wack, Wolfgang Miltz, Röhn, TA, Christian Bergsdorf, Christian Markert, Schmid, A, Bollbuck, B   +43 more
core   +1 more source