Results 121 to 130 of about 130,442 (303)

Generative Active Learning for the Search of Small-molecule Protein Binders [PDF]

arXiv
Despite substantial progress in machine learning for scientific discovery in recent years, truly de novo design of small molecules which exhibit a property of interest remains a significant challenge. We introduce LambdaZero, a generative active learning approach to search for synthesizable molecules.
arxiv  

Effect of cations on structure-linked sedimentability of lysosomal hydrolases [PDF]

, 1968
M. Anthony Verity, Robert Caper, Wendy J. Brown   +2 more
openalex   +1 more source

Properties of a β-(1→4)-glucan hydrolase from Aspergillus niger [PDF]

, 1965
AE Clarke, BA Stone
openalex   +1 more source

Amylolytic glycoside hydrolases [PDF]

Cellular and Molecular Life Sciences, 2016
Štefan Janeček, Birte Svensson
openaire   +3 more sources

Stability and detectability of testosterone esters in dried blood spots after intramuscular injections

Drug Testing and Analysis, Volume 14, Issue 11-12, Page 1926-1937, November-December 2022., 2022
We further developed the Dried Blood Spot (DBS) methodology for detection of four testosterone esters with focus on robustness and applicability in doping control. The study consisted of two parts: method development and validation, and a human administration study with intramuscular injections of 250 mg Sustanon® in healthy men.
Sara Amalie Solheim, Maren Christin Stillesby Levernæs, Jakob Mørkeberg, Anders Juul, Emmie N. Upners, Nikolai Baastrup Nordsborg, Yvette Dehnes   +6 more
wiley   +1 more source

Hydrolase activities in differentiating plant tissues [PDF]

, 1969
John S. McLean, P. B. Gahan
openalex   +1 more source

Convergent Assembly of Homo‐ and Heterotypic Ubiquitin Chains from Functionalized, Expressed Monomers via Thiol‐Ene Chemistry

Angewandte Chemie International Edition, EarlyView.
Generating functionalized ubiquitin building blocks via expression in E. coli paves the way to different di‐, tri‐, and tetra‐ubiquitin chains. Light‐induced thiol‐ene click reactions, combined with a masking and protection strategy, are harnessed to establish controlled ubiquitin chain assembly and to allow the semisynthesis of site‐selectively ...
Moritz Urschbach, Susanne Huhmann, Dominik Appel, Luca Ferrari, Dominik Vogl, Sascha Martens, Christian F. W. Becker   +6 more
wiley   +1 more source

Influence of oxygen concentration on the metabolism of Penicillium chrysogenum

Engineering in Life Sciences, Volume 23, Issue 1, January 2023., 2023
Abstract In large‐scale bioreactors, there is often insufficient mixing and as a consequence, cells experience uneven substrate and oxygen levels that influence product formation. In this study, the influence of dissolved oxygen (DO) gradients on the primary and secondary metabolism of a high producing industrial strain of Penicillium chrysogenum was ...
Agnes Janoska, Jelle J. Verheijen, Wenjung Tang, Queenie Lee, Baukje Sikkema, Walter M. van Gulik   +5 more
wiley   +1 more source

alpha-N-Benzoylarginine-2-naphthylamide Hydrolase (Cathepsin B1?) from Rat Skin. I. Preliminary Experiments with Skin Extract. [PDF]

, 1975
M. Järvinen, V. K. Hopsu‐Havu, Jan Rosenblom, Anna‐Britta Hörnfeldt, Rolf Servin, Hans Sternerup   +5 more
openalex   +1 more source

Glycyl-l-leucine hydrolase, a versatile ‘master’ dipeptidase from monkey small intestine [PDF]

, 1973
Manjusri Das, A.N. Radhakrishnan
openalex   +1 more source