Results 201 to 210 of about 297,801 (378)

Advancing the Exploration of the Ubiquitin‐like Protein FUBI with Synthetic Chemical Tools

open access: yesChemBioChem, EarlyView.
This study unveils a novel synthetic platform by solid‐phase peptide synthesis for generating FUBI‐based chemical tools to investigate FUBIylation, a poorly understood ubiquitin‐like signaling process linked to cancer. By employing these innovative probes, we uncover novel FUBI interactors, paving the way for transformative insights into FUBI biology ...
Francesca D’Amico   +8 more
wiley   +1 more source

Disruption of Retriever Function Impacts Retrograde Trafficking From Endosomes

open access: yesCell Biology International, EarlyView.
ABSTRACT Within endosomes cargo proteins are sorted and packaged into endosomal‐transport carriers (ETCs) enabling their delivery to other intracellular compartments. Retromer, a conserved multimeric protein complex, has defined functions in sorting cargo mediating formation of ETCs for both retrograde trafficking back to the trans‐Golgi network (TGN ...
Zebin Li, Zhe Yang, Rohan D. Teasdale
wiley   +1 more source

C13‐Deacylase from Nocardioides albus Resp. Streptomyces sp., Catalyzing Side Chain Hydrolysis on the Taxane Core

open access: yesChemCatChem, EarlyView.
An enzyme that has been identified and characterized as capable of hydrolyzing paclitaxel (Taxol), a key anticancer drug derived from Pacific yew (Taxus brevifolia) has been identified. Molecular docking (MD) simulations map the catalytic triad and critical residues that drive substrate‐enzyme interactions. The findings indicate the catalytic potential
Jinfen Su   +3 more
wiley   +1 more source

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