Results 21 to 30 of about 81,486 (244)

Molecular characterization and functional annotation of a hypothetical protein (SCO0618) of A3(2) [PDF]

Genomics & Informatics, 2020
Streptomyces coelicolor is a gram-positive soil bacterium which is well known for the production of several antibiotics used in various biotechnological applications. But numerous proteins from its genome are considered hypothetical proteins.
Nadim Ferdous, Mahjerin Nasrin Reza, Md. Tabassum Hossain Emon, Md. Shariful Islam, A. K. M. Mohiuddin, Mohammad Uzzal Hossain   +5 more
doaj   +1 more source

Analysis of Bacterial Isolates Capable of Partially Degrading Polyethylene Terephthalate [PDF]

Brazilian Archives of Biology and Technology
In this work, we studied 46 bacterial isolates to determine their potential for polyethylene terephthalate (PET) degradation. Only eight lipase-positive isolates were pre-selected to continue analysis.
Ana Sofía Fierros-Peña, Maribel Mireles-Martínez, Jorge Alberto Torres-Ortega, Marco Antonio Garza-Navarro, Jesús Manuel Villegas-Mendoza, Ninfa María Rosas-García   +5 more
doaj   +1 more source

Enzymes in the Content of Combined Antimicrobials as Improvers of Their Action

Вестник войск РХБ защиты
Accumulating information about the growing number of microorganisms that are resistant to the antibiotics used, on the one hand, and the emergence of information about the presence of laboratories in which closed work is carried out with microbial ...
N. A. Stepanov, A. G. Aslanli, M. V. Domnin, E. N. Efremenko   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Biocatalytic Recycling of Polyethylene Terephthalate: From Conventional to Innovative Routes for Transforming Plastic and Textile Waste into Renewable Resources

Resources
The rapid accumulation of plastic and textile waste, particularly polyethylene terephthalate (PET), has emerged as a global challenge for sustainable resource management.
Damayanti Damayanti, David Septian Sumanto Marpaung, Abdul Rozak Kodarif, Andri Sanjaya, Desi Riana Saputri, Yunita Fahni, Lutfia Rahmiyati, Putri Zulva Silvia, Dewi Qurrota A’yuni, Calaelma Logys Imalia, Dikri Uzlifah Janah, Ho Shing Wu   +11 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Stereochemical aspects of the nucleophilic attack in different classes of l-asparaginases

IUCrJ
L-Asparaginases hydrolyze L-asparagine to L-aspartate with the release of ammonia. Currently, three completely unrelated structural classes of L-asparaginases are known, further subdivided into five types.
Miroslaw Gilski, Kinga Pokrywka, Mariusz Jaskolski   +2 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Biocatalysis for Biobased Chemicals

Biomolecules, 2013
The design and development of greener processes that are safe and friendly is an irreversible trend that is driven by sustainable and economic issues.
Rubén de Regil, Georgina Sandoval
doaj   +1 more source