Anti-tumor effect in human lung cancer by a combination treatment of novel histone deacetylase inhibitors: SL142 or SL325 and retinoic acids. [PDF]
PLoS ONE, 2010 Histone deacetylase (HDAC) inhibitors arrest cancer cell growth and cause apoptosis with low toxicity thereby constituting a promising treatment for cancer.
Shaoteng Han +7 more
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Histone deacetylases as new therapy targets for platinum-resistant epithelial ovarian cancer [PDF]
, 2016 Introduction: In developed countries, ovarian cancer is the fourth most common cancer in women. Due to the nonspecific symptomatology associated with the disease many patients with ovarian cancer are diagnosed late, which leads to significantly poorer ...
A Hayashi +130 more
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Hydroxamic Acids in Asymmetric Synthesis [PDF]
Accounts of Chemical Research, 2012 Metal-catalyzed stereoselective reactions are a central theme in organic chemistry research. In these reactions, the stereoselection is achieved predominantly by introducing chiral ligands at the metal catalyst's center. For decades, researchers have sought better chiral ligands for asymmetric catalysis and have made great progress.
Zhi, Li, Hisashi, Yamamoto
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Selective inhibition of carotenoid cleavage dioxygenases : phenotypic effects on shoot branching [PDF]
, 2009 Members of the carotenoid cleavage dioxygenase family catalyse the oxidative cleavage of carotenoids at various chain positions, leading to the formation of a wide range of apocarotenoid signalling molecules.
Akiyama +52 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Oxazolidinone hydroxamic acid derivatives were synthesised and evaluated for inhibitory activity against leukotriene (LT) biosynthesis in three in vitro cell-based test systems and on direct inhibition of recombinant human 5-lipoxygenase (5-LO). Thirteen
Oludotun A. Phillips +2 more
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Journal of Pharmacy and Pharmacology, 1964 Abstract The preparation of certain quinolines, quinazolines, quinoxalines, benzoxazines and benzothiazines containing the cyclic hydroxamic grouping is described. In vitro antibacterial activities showed that no compound had a broader spectrum of activity than the known 1,2-dihydro-1-hydroxy-2-oxoquinoline.
R T, COUTTS, D, NOBLE, D G, WIBBERLEY
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Phase I dose-escalation study of the mTOR inhibitor sirolimus and the HDAC inhibitor vorinostat in patients with advanced malignancy. [PDF]
, 2016 Preclinical models suggest that histone deacetylase (HDAC) and mammalian target of rapamycin (mTOR) inhibitors have synergistic anticancer activity. We designed a phase I study to determine the safety, maximum tolerated dose (MTD), recommended phase II ...
Falchook, Gerald S. +17 more
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A perspective on using experiment and theory to identify design principles in dye-sensitized solar cells [PDF]
, 2018 Dye-sensitized solar cells (DSCs) have been the subject of wide-ranging studies for many years because of their potential for large-scale manufacturing using roll-to-roll processing allied to their use of earth abundant raw materials.
Abuabara SG +18 more
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PREPARATION OF NEW COMPLEXES DERIVED FROM DIETHYLGLUTART AND STUDYING THEIR SPECTRUM PROPERTIES AND BIOLOGICAL ACTIVITY [PDF]
مجلة جامعة الانبار للعلوم الصرفة, 2012 This research designed to be on four steps: The first step includes preparation of a group legends derived from glutaric acid, the second step which the research includes is converting the acid derivatives that being prepared into hydroxamic acids.
SHAKIR F TULEAB
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Rescue of cell cycle progression in BRAF inhibitor–resistant human melanoma by a chromatin modifier
Tumor Biology, 2017 The BRAF V600E -specific inhibitor vemurafenib blocks mitogen-activated protein kinase pathway and induces cell cycle arrest at G0/G1 phase leading to apoptosis of melanomas.
Antoni X Torres-Collado +2 more
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