Results 31 to 40 of about 30,527 (215)

Histone deacetylases as new therapy targets for platinum-resistant epithelial ovarian cancer [PDF]

, 2016
Introduction: In developed countries, ovarian cancer is the fourth most common cancer in women. Due to the nonspecific symptomatology associated with the disease many patients with ovarian cancer are diagnosed late, which leads to significantly poorer ...
A Hayashi, A Mai, A Saito, A Vannini, A Villar-Garea, AA Lane, AJ Dembo, AJ Wilson, Albandri Alfraidi, AM Abukhdeir, Aun Muhammad, AW Kurian, B Sorbe, BA Goff, BD Strahl, BH Huang, BY Karlan, C Aghajanian, C Bosetti, C Campas-Moya, C Gomez-Raposo, CJ Dunton, CM Grozinger, CS Marcus, CT Lin, D Khabele, D Matei, D Mottet, D Strumberg, D Waltregny, DC Drummond, DD Bowtell, DE Marsden, DK Armstrong, DM Dinulescu, Dmitri Pchejetski, DO Bauerschlag, E Hu, E Smolle, E Verdin, G Piperno, G Tortolero-Luna, H Naora, HA Risch, Heba Alshaker, HL Cheng, I Cetin, IK Kolasa, J Boyd, J Morrison, J Permuth-Wey, J Plisiecka-Halasa, J Prat, J Sonnemann, J Zhang, JA Rauh-Hain, JE Bolden, JE Palmer, JF Stratton, JH Choi, JJ Hwang, JL Benedet, JL MacDonald, JL Walker, JM Piek, JP Secrist, JR Graff, JR Ribeiro, K Kudoh, K Ozaki, K Sawada, K Struhl, KA Lowe, KB Glaser, Keith Sacco, KF McGonigle, KR Cho, L Dai, Leonardo Monzon, M Booth, M Fung-Kee-Fung, M Kartalou, M Markman, M Ohmichi, M Schuijer, MF Fathalla, MJ Piccart, MJ Scanlan, MK Tuxen, ML Friedlander, MM Leitao, MS Finnin, MS Kim, N Einhorn, N Einhorn, N Takai, N Takai, N Takai, NC Hait, NG Gavalas, NS Bese, P Marks, P Zhu, PH Wang, R Furumai, RA Burger, RA Burger, RC Bast Jr, RF Ozols, RL Coleman, RP Warrell Jr, RP Wernyj, S Gregoire, S Rinaldi, S Senese, S Spiegel, SA Cannistra, SA Gayther, SA Gayther, SC Modesitt, SR Wedge, T Meyer, TJ Herzog, TJ Perren, TL Klug, V Auner, V Conteduca, W Fischle, W Weichert, X Qian, YV Shebzukhov   +130 more
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Inhibitors of bacterial and plants urease [PDF]

, 2013
Urease is an important virulence factor for Helicobacter pylori and Proteus mirabilis as well as in environmental transformations of certain nitrogenous compounds.
Macegoniuk, Katarzyna
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DETERMINAÇÃO DO TEOR DE BIODIESEL EM DIESEL EMPREGANDO O ENSAIO COLORIMÉTRICO DO ÁCIDO HIDROXÂMICO

Química Nova, 2015
The aim of this paper was to use colorimetric assays for hydroxamic acid to quantify the biodiesel content in diesel and compare it with the traditional method (infrared spectroscopy, using the EN 14078 method).
Roberta P. M. da Costa, Thaiane C. Khalil, Amanda P. F. dos Santos, Débora F. de Andrade, Luiz A. d'Avila   +4 more
doaj   +1 more source

Inhibition of histone deacetylase as a treatment for cardiac hypertrophy [PDF]

, 2005
The present invention provides for methods of treating and preventing cardiac hypertrophy. Class II HDACs, which are known to participate in regulation of chromatin structure and gene expression, have been shown to have beneficial effects on cardiac ...
Bristow, Michael R., Long, Carlin, McKinsey, Timothy A., Olson, Eric N.   +3 more
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Synthesis and HDAC inhibitory activity of pyrimidine-based hydroxamic acids

Beilstein Journal of Organic Chemistry, 2022
Histone deacetylases (HDACs) play an essential role in the transcriptional regulation of cells through the deacetylation of nuclear histone and non-histone proteins and are promising therapeutic targets for the treatment of various diseases.
Virginija Jakubkiene, Gabrielius Ernis Valiulis, Markus Schweipert, Asta Zubriene, Daumantas Matulis, Franz-Josef Meyer-Almes, Sigitas Tumkevicius   +6 more
doaj   +1 more source

Potential SARS-CoV-2 3CLpro inhibitors from chromene, flavonoid and hydroxamic acid compound based on FRET assay, docking and pharmacophore studies

Results in Chemistry, 2021
This present study reports some natural products and one hydroxamic acid synthetic compound which were previously reported as matrix metalloproteinase-9 (MMP-9) inhibitors to be evaluated for their inhibition toward severe acute respiratory syndrome ...
Maywan Hariono, Pandu Hariyono, Rini Dwiastuti, Wahyuning Setyani, Muhammad Yusuf, Nurul Salin, Habibah Wahab   +6 more
doaj   +1 more source

Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity [PDF]

, 2016
Background: Histone deacetylase inhibitors (HDACi) exert multiple cytotoxic actions on cancer cells. Currently, different synthetic HDACi are in clinical use or clinical trials; nevertheless, since both pro-invasive and anti-invasive activities have been
Andrade, Ricardo, Arluzea, Jon, Aréchaga, Juan, De Wever, Olivier, Díaz-Núñez, María, Díez-Torre, Alejandro, Silió, Margarita   +6 more
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Evaluation of the properties of complexing agent-collectors of eudialyte flotation [PDF]

Vestnik MGTU, 2015
Acid-based and complexing properties of reagent-collectors (carboxylic and hydroxamic acids, styrylphosphonic acid and dialkyl ether of phosphoric acid) for flotation of zirconium-containing minerals have been studied.
Mitrofanova G.V., Ivanova V.A., Nikitina I.V.   +2 more
doaj  

Novel Multitarget Hydroxamic Acids with a Natural Origin CAP Group against Alzheimer’s Disease: Synthesis, Docking and Biological Evaluation

Pharmaceutics, 2021
Hydroxamic acids are one of the most promising and actively studied classes of chemical compounds in medicinal chemistry. In this study, we describe the directed synthesis and effects of HDAC6 inhibitors.
Margarita Neganova, Yulia Aleksandrova, Evgenii Suslov, Evgenii Mozhaitsev, Aldar Munkuev, Dmitry Tsypyshev, Maria Chicheva, Artem Rogachev, Olga Sukocheva, Konstantin Volcho, Sergey Klochkov   +10 more
doaj   +1 more source

Field-effect transistors assembled from functionalized carbon nanotubes

, 2006
We have fabricated field effect transistors from carbon nanotubes using a novel selective placement scheme. We use carbon nanotubes that are covalently bound to molecules containing hydroxamic acid functionality.
Appenzeller J., Auvray S., Avouris, Avouris Ph., Bachtold A., Bahr J. L., Banerjee S., Bethune D. S., Bonard J. M., Chen J., Chen Z., Cheng C., Choi K. H., Collins P. G., Cui Y., Dai H., Derycke V., Duan X., Dyke C. A., Folkers J. P., Hannon J. B., Heald C. G. R., Huang Y., Iijima S., Javey A., Jin S., Johnston D. E., Kataura H., Klinke C., Kooi S. E., Lee S. W., Lee Y. S., Lin Y. M., Martel R., McEuen P. L., Mirkin C. A., Morales A. M., Niyogi S., Perebeinos V., Radosavljevic M., Spataru C. D., Wind S. J.   +41 more
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