Results 71 to 80 of about 5,129,522 (237)

Design of Fluorescent Coumarin-Hydroxamic Acid Derivatives as Inhibitors of HDACs: Synthesis, Anti-Proliferative Evaluation and Docking Studies

open access: yesMolecules, 2020
Coumarin-hydroxamic acid derivatives 7a–k were herein designed with a dual purpose: as antiproliferative agents and fluorescent probes. The compounds were synthesized in moderate yields (30–87%) through a simple methodology, biological evaluation was ...
Santiago García   +9 more
doaj   +1 more source

Deprotective Functionalization: An Emerging Concept for Amine Reactivity

open access: yesChemistry – A European Journal, Volume 32, Issue 4, 23 January 2026.
While protecting groups are indispensable in total synthesis to avoid undesired reactivity, installation and removal of protecting groups lead to an increase in the step‐count, cost, waste production and time requirement. One approach tackling these drawbacks is deprotective functionalization, which combines deprotection and postfunctionalization in a ...
Irmgard Tiefenbrunner   +2 more
wiley   +1 more source

A Simple Method for the Isolation and Purification of 2,4-Dihydroxy-7-Methoxy-2H-1,4-Benzoxazin-3(4H)-One (DIMBOA) from Maize (Zea mays L.) Seedlings

open access: yesJournal of Integrative Agriculture, 2013
2,4-Dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA), the dominant benzoxazinoid hydroxamic acid in maize (Zea Mays L.), serves as important factors of resistance against insects and microbial diseases, allelochemicals used in competition with ...
Jing LI   +8 more
doaj   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, Volume 600, Issue 2, Page 215-225, January 2026.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

hydroxamic acids

open access: yes, 2014
Citation: 'hydroxamic acids' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.H02911 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Methods for Hydroxamic Acid Synthesis [PDF]

open access: yesCurrent Organic Chemistry, 2019
Substituted hydroxamic acid is one of the most extensively studied pharmacophores because of their ability to chelate biologically important metal ions to modulate various enzymes, such as HDACs, urease, metallopeptidase, and carbonic anhydrase. Syntheses and biological studies of various classes of hydroxamic acid derivatives have been reported in ...
openaire   +2 more sources

Preparation and Characterization of Pectin Hydroxamates from Citrus Unshiu Peels

open access: yesJournal of Excipients and Food Chemicals, 2016
Pectin was extracted from unshiu orange (Citrus unshiu) peels and was subjected to chemical modification using hydroxamic acid. The structural and physical properties of the resulting derivatives were investigated as a function of hydroxamic acid content
In Young Bae   +3 more
doaj  

Preparation and Characterization of Pectin Hydroxamates from Citrus Unshiu Peels [PDF]

open access: yesJournal of Excipients and Food Chemicals
Pectin was extracted from unshiu orange (Citrus unshiu) peels and was subjected to chemical modification using hydroxamic acid. The structural and physical properties of the resulting derivatives were investigated as a function of hydroxamic acid content
In Young Bae   +3 more
doaj  

Fdb1 and Fdb2, Fusarium verticillioides Loci Necessary for Detoxification of Preformed Antimicrobials from Corn

open access: yesMolecular Plant-Microbe Interactions, 2002
Fusarium verticillioides is a fungus of significant economic importance because of its deleterious effects on plant and animal health and on the quality of their products. Corn (Zea mays) is the primary host for F.
A. E. Glenn, S. E. Gold, C. W. Bacon
doaj   +1 more source

Synthesis of Non‐Isocyanate Poly(Sulfide Urethane) Adhesives by Thermally Initiated Thiol‐Ene Polymerization

open access: yesMacromolecular Chemistry and Physics, Volume 227, Issue 2, 29 January 2026.
Three routes to poly(sulfide urethane)s were compared, identifying thermally initiated thiol‐ene polyaddition as very effective. Using α,ω‐diene‐functionalized carbamates and aliphatic dithiols under solvent‐free conditions with dicumyl peroxide as an initiator, high‐molar‐mass polyurethanes (Mn up to 19 kg mol−1) were obtained, with fewer byproducts ...
Nichollas G. Jaques   +6 more
wiley   +1 more source

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