Results 101 to 110 of about 7,137 (264)
Drug-therapy networks and the predictions of novel drug targets [PDF]
, 2008 Recently, a number of drug-therapy, disease, drug, and drug-target networks have been introduced. Here we suggest novel methods for network-based prediction of novel drug targets and for improvement of drug efficiency by analysing the effects of drugs on
Csermely, Peter +2 more
core +3 more sources
JIMD Reports, Volume 66, Issue 1, January 2025.Abstract Background Classic homocystinuria (HCU) is a rare inborn metabolic disease that is generally asymptomatic at birth. If untreated, it can cause a wide range of complications including intellectual disability, lens dislocation, and thromboembolism.
Ahmed Sarar Mohamed +5 more
wiley +1 more source
Severe Hemolytic Crisis in Uncontrolled AIHA Triggered by Dengue
Case Reports in Medicine, Volume 2025, Issue 1, 2025.We present the case of a woman with a history of autoimmune hemolytic anemia (AIHA), untreated for 1 year, who presented with fever, myalgia, arthralgia, anemia, and thrombocytopenia, along with a positive nonstructural protein antigen 1 (NS1Ag) test. During the course of dengue, the patient developed severe hemolytic anemia, posing a potentially life ...
Christian Alberto Rodriguez-Saldaña +6 more
wiley +1 more source
Military Medical Research, 2019 Inhalation injury is often associated with burns and significantly increases morbidity and mortality. The main toxic components of fire smoke are carbon monoxide, hydrogen cyanide, and irritants.
Tian-Tian Yan +5 more
doaj +1 more source
Axial Ligation and Redox Changes at the Cobalt Ion in Cobalamin Bound to Corrinoid Iron-Sulfur Protein (CoFeSP) or in Solution Characterized by XAS and DFT [PDF]
, 2016 A cobalamin (Cbl) cofactor in corrinoid iron-sulfur protein (CoFeSP) is the primary methyl group donor and acceptor in biological carbon oxide conversion along the reductive acetyl-CoA pathway.
Dau, Holger +6 more
core +3 more sources
The Immunomodulatory Effect of Vitamin B12 in Pernicious Anemia: A Systematic Review
Oxidative Medicine and Cellular Longevity, Volume 2025, Issue 1, 2025.Objectives: The aim of this review is to draw attention to key findings from various published studies concerning the effect of methylcobalamin/cyanocobalamin on the immune response of patients diagnosed with pernicious anemia (PA). Methods: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA ...
Tesfaye Engdaw Habtie +6 more
wiley +1 more source
Case Reports in Medicine, 2015 Cyanide is rapidly reacting and causes arrest of aerobic metabolism. The symptoms are diffuse and lethal and require high clinical suspicion. Remediation of symptoms and mortality is highly dependent on quick treatment with a cyanide antidote. Presently,
Andrew Meillier, Cara Heller
doaj +1 more source
Hong Kong Poison Information Centre: Annual report 2021
Hong Kong Journal of Emergency Medicine, Volume 31, Issue 6, Page 339-353, December 2024.Abstract Introduction The Hong Kong Poison Information Centre (HKPIC) has been providing consultation services to healthcare professionals and collecting epidemiological data on poisoning in Hong Kong since 2005. Objective To analyse and report the poisoning data from HKPIC in 2021.
Tin Yat Anthony Chow +3 more
wiley +1 more source
A systematic review and meta‐analysis of functional vitamin B12 status among adult vegans
Nutrition Bulletin, Volume 49, Issue 4, Page 463-479, December 2024.Abstract The dietary intake of vitamin B12 among unsupplemented vegans is notably lower compared to both vegetarians and omnivores. Prolonged low intakes of vitamin B12, such as seen in those adhering to a vegan diet, lead to physiological deficiency of vitamin B12 and an elevated risk of B12‐related morbidity.
Ali Niklewicz +3 more
wiley +1 more source
Assessment of cellular cobalamin metabolism in Gaucher disease
BMC Medical Genetics, 2020 Background Gaucher disease (GD) is a lysosomal disorder caused by biallelic pathogenic mutations in the GBA1 gene that encodes beta-glucosidase (GCase), and more rarely, by a deficiency in the GCase activator, saposin C.
Suelen Porto Basgalupp +6 more
doaj +1 more source