Results 181 to 190 of about 8,578 (226)

Predicting the Response of Hydroxocobalamin in Postoperative Vasoplegia in Recipients of Cardiopulmonary Bypass.

Journal of Cardiothoracic and Vascular Anesthesia, 2022
OBJECTIVE The primary aim of this study was to identify predictors of response to hydroxocobalamin. DESIGN A retrospective cohort study. SETTING A single large academic medical center within the cardiovascular surgery intensive care unit ...
Nicholas J Vollmer, P. Wieruszewski, N. Martin, Troy G. Seelhammer, E. Wittwer, C. Nabzdyk, Kristin Mara, Scott D. Nei   +7 more
semanticscholar   +1 more source

The use of hydroxocobalamin in the Schilling test

European Journal of Haematology, 1986
Hydroxocobalamin and cyanocobalamin have been compared as the ‘flushing dose’ in the Schilling test. In healthy, haematologically normal subjects excretion of the test dose was greater following a hydroxocobalamin flushing dose than following a cyanocobalamin flushing dose, and to a lesser extent this was also true in patients requiring investigation ...
Barbara J. Bain, D. M. Clark, J. Wallis
openaire   +3 more sources

Hydroxocobalamin

Reactions weekly, 2023

semanticscholar   +6 more sources

Clinical and biochemical outcomes in cobalamin C deficiency with use of high‐dose hydroxocobalamin in the early neonatal period

American Journal of Medical Genetics. Part A, 2022
This case report describes a patient with early‐onset cobalamin C deficiency who was started on treatment with high‐dose parenteral hydroxocobalamin after diagnosis at 13 days of life. Prior to diagnosis, initial presenting symptoms included poor feeding,
Abigail Kacpura, Marta Frigeni, Kathryn Gunther, Laura S. Farach   +3 more
semanticscholar   +1 more source

Hydroxocobalamin Versus Methylene Blue for Treatment of Vasoplegic Shock Following Cardiopulmonary Bypass: A Systematic Review and Meta-analysis.

Journal of Cardiothoracic and Vascular Anesthesia
OBJECTIVES To summarize the evidence of the hemodynamic effects and vasopressor requirements of adult cardiac surgery patients with vasoplegic shock treated with hydroxocobalamin or methylene blue. DESIGN Systematic review and meta-analysis.
Matthew Cadd, Ultan Watson, Thomas Kilpatrick, Ben Hardy, Laura Gallop, Alexander Gerard, Cyrille Cabaret   +6 more
semanticscholar   +1 more source

Iatrogenic pediatric hydroxocobalamin overdose

The American Journal of Emergency Medicine, 2019
Hydroxocobalamin, a precursor molecule to vitamin B12, has emerged as the preferred empiric treatment for patients rescued from enclosed-space fires with concern for inhalational injury and potential concomitant cyanide toxicity. Limited data exist on the effects of hydroxocobalamin toxicity, particularly in pediatric patients.We report a case of a ...
Andrew J. Latimer, Matthew Valento, Betty C. Chen, Benjamin T. Friedman   +3 more
openaire   +3 more sources

THE PREPARATION OF RADIOACTIVE HYDROXOCOBALAMIN

The Lancet, 1962
A method for the preparation of hydroxocobalamin from Co/sup 60/-labeled cyanocobalamin by photolysis in microgram amounts is described. As light sources, direct sunlight, north daylight, and tungsten-filament, or fluorescent lamps were used. After irradiation in aqueous solution, small columns of carboxymethyl (CM) cellulose (1 x 3 cm) were used to ...
openaire   +3 more sources

Elevated methemoglobin levels in patients treated with hydroxocobalamin: a case series and in-vitro analysis

Clinical toxicology, 2022
Background Historically, the first step in treating cyanide (CN-) toxicity utilized antidotes to induce methemoglobinemia. This is concerning in patients who are already hypoxemic or have elevated carboxyhemoglobin.
E. Kiernan, J. Carpenter, C. Dunkley, T. Moran, Lindsay Schaack Rothstein, Elizabeth Silver, M. Salehi, Dave Koch, B. Morgan, B. Murray   +9 more
semanticscholar   +1 more source

Hydroxocobalamin to treat refractory vasoplegia following phaeochromocytoma resection in a child

Anaesthesia Reports, 2022
Phaeochromocytomas and paragangliomas are rare neuroendocrine tumours that often secrete catecholamines, which can cause dramatic swings in blood pressure and end‐organ damage.
A. Giustini, E. Rowe, F. Perez, F. Mihm
semanticscholar   +1 more source

Photochemical interaction of cyanocobalamin and hydroxocobalamin with cysteine

Journal of Molecular Structure, 2021
Abstract The photolysis of cyanocobalamin (B12) and hydroxocobalamin (B12b) in the presence of cysteine (CYS) is investigated. The reactions follow first–order kinetics and the values of first–order constants (kobs) at pH 2.0–12.0 range from 0.82–9.25 × 10–4 min–1 and 4.93–16.40 × 10–4 min–1, for B12 and B12b, respectively.
Kiran Qadeer, Adeel Arsalan, Iqbal Ahmad, Kaneez Fatima, Zubair Anwar, Sofia Ahmed, Saif ur Rehman Khattak, Shaukat Mahmud   +7 more
openaire   +2 more sources