Results 51 to 60 of about 164 (88)

H2S‐Releasing Aspirin Nanoparticles Alleviate Endometriosis and Associated Anxiety

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Albumin nanoparticles loaded with an H2S‐releasing aspirin derivative (ACS14) hitchhiking neutrophils after intraperitoneal injection and preferentially accumulate in endometriosis lesions in mice. The treatment suppresses lesion growth by regulating PI3K/Akt and reduces inflammation by inhibiting NF‐κB.
Mengni Zhou, Renbin Dou, Rong Wu, Yunyu Xu, Ying Wang, Peng Wang, Jinfu Li, Pengcheng Lu, Yu Mao, Jieying Qian, Yunjiao Zhang, Jiqian Zhang, Shasha Zhu   +12 more
wiley   +1 more source

Experts' Opinion on Decontamination and Antidote Strategies: Complementing Contemporary Expert Consensus and Evidence to Optimize Preparedness and Response to CBRN Threats in the Middle East and North Africa

Journal of Contingencies and Crisis Management, Volume 34, Issue 1, March 2026.
ABSTRACT Chemical, biological, radiological, and nuclear (CBRN) incidents present escalating challenges, particularly in geopolitically unstable regions such as the Middle East and North Africa. Despite advances, gaps exist regarding optimal decontamination protocols and agent‐specific antidote selection algorithms, exacerbated by variable operational ...
Hassan Farhat, Derrick Tin, Heejun Shin, Saleh Fares Al‐Ali, Daren Mochrie, Brendon Morris, Gregory Ciottone   +6 more
wiley   +1 more source

A double-blind, randomized, comparative study of the use of a combination of uridine triphosphate trisodium, cytidine monophosphate disodium, and hydroxocobalamin, versus isolated treatment with hydroxocobalamin, in patients presenting with compressive neuralgias

Journal of Pain Research, 2017
Henrique Goldberg,1 Marco Antonio Mibielli,2 Carlos Pereira Nunes,2 Stephanie Wrobel Goldberg,3 Luiz Buchman,4 Spyros GE Mezitis,5 Helio Rzetelna,6 Lisa Oliveira,2 Mauro Geller,2 Fernanda Wajnsztajn7 1UERJ Medical School, Rio de Janeiro, Brazil; 2UNIFESO
Goldberg H, Mibielli MA, Nunes CP, Goldberg SW, Buchman L, Mezitis SG, Rzetelna H, Oliveira L, Geller M, Wajnsztajn F   +9 more
doaj  

Vitamin B12 deficiency in a pediatric patient with gastric obstruction and jejunal feeding dependence: A case report

JPGN Reports, Volume 7, Issue 1, Page 174-178, February 2026.
Abstract Pediatric B12 deficiency is most caused by insufficient dietary intake, malabsorption or autoimmune gastritis. We present a unique case of B12 deficiency in a pediatric patient with complex gastrointestinal anatomy and jejunal nutritional dependence nearly two decades after unsuccessful surgical intervention.
Angela H. Nguyen, Dorsey Bass, Rachel E. Herdes   +2 more
wiley   +1 more source

Pharmacological treatment of inhalation injury after nuclear or radiological incidents: The Chinese and German approach

Military Medical Research, 2019
Inhalation injury is often associated with burns and significantly increases morbidity and mortality. The main toxic components of fire smoke are carbon monoxide, hydrogen cyanide, and irritants.
Tian-Tian Yan, Guo-An Lin, Min-Jie Wang, Andreas Lamkowski, Matthias Port, Alexis Rump   +5 more
doaj   +1 more source

Acute Cyanide Poisoning: Hydroxocobalamin and Sodium Thiosulfate Treatments with Two Outcomes following One Exposure Event

Case Reports in Medicine, 2015
Cyanide is rapidly reacting and causes arrest of aerobic metabolism. The symptoms are diffuse and lethal and require high clinical suspicion. Remediation of symptoms and mortality is highly dependent on quick treatment with a cyanide antidote. Presently,
Andrew Meillier, Cara Heller
doaj   +1 more source

Advanced Ophthalmic Drug Delivery in Homocystinuria Type CblC: A Translational Review of Ophthalmic Pathologies and Therapeutic Opportunities

Pharmaceutics
Homocystinuria type CblC is a congenital error in cobalamin metabolism characterized by increased homocysteine and methylmalonic acid levels, together with a reduced methionine availability.
Selene Cuello-Rodríguez, Martina Sanna, Imelda Lecoeuche, Bruno Sarmento, Francisco J. Otero-Espinar, Victoria Díaz-Tomé   +5 more
doaj   +1 more source

Rapid Improvement of Hyperpigmentation, Growth, and Developmental Milestones With High‐Dose Hydroxocobalamin, Betaine, and Folinic Acid Treatment: The First Patient With Cobalamin G Deficiency in Taiwan

JIMD Reports
In this report, we present the case of a 16‐month‐old patient who was diagnosed with cobalamin G deficiency at 4 months of age via whole exome sequencing by detecting compound heterozygous variants of uncertain significance (VUS) in the MTR gene: (1) c ...
Chi‐Tang Wu, Shih‐Ju Huang, Chu‐Chin Chen, Pao‐Chin Chiu   +3 more
doaj   +1 more source

Assessment of cellular cobalamin metabolism in Gaucher disease

BMC Medical Genetics, 2020
Background Gaucher disease (GD) is a lysosomal disorder caused by biallelic pathogenic mutations in the GBA1 gene that encodes beta-glucosidase (GCase), and more rarely, by a deficiency in the GCase activator, saposin C.
Suelen Porto Basgalupp, Marina Siebert, Charles Ferreira, Sidney Behringer, Ute Spiekerkoetter, Luciana Hannibal, Ida Vanessa Doederlein Schwartz   +6 more
doaj   +1 more source

Evaluation of outcomes for patients with nitrous oxide-related myeloneuropathy treated with self-injection of hydroxocobalamin versus nurse-led injections on an ambulatory care pathway

BMJ Neurology Open
Background Nitrous oxide (N₂O)-related neurotoxicity is a significant public health concern among young people in the UK. Recognition necessitates timely diagnosis, abstinence from N₂O consumption and replacement of vitamin B12, usually via intramuscular
Alastair J Noyce, Laura Smith, Marta Patyjewicz, Barbara Onen, Mohamoud Hashi, Katrina Mamigo, Eunice Adu-poku, Gillian Fox   +7 more
doaj   +1 more source