Results 41 to 50 of about 72,897 (256)

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

A comparative study of the mechanical integrity of natural hydroxyapatite scaffolds prepared from two biogenic sources using a low compaction pressure method

Results in Physics, 2020
With a view to enhancing laboratory and application-based pedagogical approaches in bioengineering, a comparison of the physical, chemical and mechanical properties of natural hydroxyapatite produced from non-separated animal bones (NB) and catfish bones
E.S. Akpan, M. Dauda, L.S. Kuburi, D.O. Obada, D. Dodoo-Arhin   +4 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Caracterization and Compressive Strength of Biocomposite Hydroxyapatite-Borosilicate with Hight Temperature Sintering

MATEC Web of Conferences, 2018
The use of Hydroxyapatite as bone graft material continues to increase. To utilize hydroxyapatite, it is often formed into biocomposite. The formation of hydroxyapatite biocomposite intended to address the fragile hydroxyapatite weaknesses.
Burmawi, Jamarun Novesar, Arief Syukri, Gunawarman   +3 more
doaj   +1 more source

Bioadhesive‐Integrated 3D‐Printed Multilayer Scaffolds Secure a Mechanically‐Stable Osteoimmune Niche for Enhanced Bone Augmentation

Advanced Science, EarlyView.
A 3D‑printed multilayer adhesive scaffold, firmly anchored to bone defects by simple finger pressing, suppresses micromotion and secures mechanical stability of the osteogenic niche. This stabilization likely contributes to the enhanced bone augmentation by fostering a pro‑regenerative mechano‐immune profile—characterized by M2‑like macrophage ...
Delu Zhao, Qiuyi Li, Lingyun Wang, Chongao Zhang, Yutian Cheng, Shuang Liu, Fulan Wei, Zheqin Dong   +7 more
wiley   +1 more source

Densification of hydroxyapatite through cold sintering process: Role of liquid phase chemistry and physical characteristic of HA powder

Open Ceramics
Hydroxyapatite is a well-known bioactive material widely employed in bone regeneration applications. Densifying hydroxyapatite at the nanoscale remains challenging with conventional sintering methods.
Muthusundar Kumar, Mohamed Aymen Ben Achour, Marie Lasgorceix, Paulo Quadros, Rosica Mincheva, Jean-Marie Raquez, Anne Leriche   +6 more
doaj   +1 more source

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Atmospheric Water Harvesting Through Polymer Hydrogel Sorbents: Materials Chemistry, Design Strategies, and Applications

Advanced Science, EarlyView.
Polymer‐based hydrogels have emerged as promising materials for atmospheric water harvesting (AWH) due to their high water affinity, tunable network structure, and excellent moisture adsorption‐desorption performance. Functional hydrogel systems enable efficient water capture and controlled release under low‐energy conditions, offering a sustainable ...
Swagata Datta, Sushmit Sen, Nilanjan Dey, Amrita Chatterjee, Ananya Sadhu, Sudipta Sarkar, Pradip K. Maji   +6 more
wiley   +1 more source

BIOMATERIALS BASED ON NANOHYDROXYAPATITE [PDF]

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2014
In this study, the porous hydroxyapatite-filled cellulose acetate scaffolds were prepared via dry-wet phase inversion method by dispersing hydroxyapatite nanoparticles in the polymeric matrix.
Gabriela Ciobanu, Constantin Luca, Octavian Ciobanu   +2 more
doaj