Results 191 to 200 of about 1,972 (243)
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International Journal of Neuropharmacology, 1964
Abstract The author presents a general review of the pharmacology of sodium 4-hydroxybutyrate, the principal elements of which are: (a) very low toxicity, and metabolic application; (b) the hypnotic activity, which does not cause a decrease in the intensity of oxidative processes; (c) the potentiating action on anaesthetics and neuroplegics ...
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Abstract The author presents a general review of the pharmacology of sodium 4-hydroxybutyrate, the principal elements of which are: (a) very low toxicity, and metabolic application; (b) the hypnotic activity, which does not cause a decrease in the intensity of oxidative processes; (c) the potentiating action on anaesthetics and neuroplegics ...
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BioEssays, 1984
AbstractRecent work has led to the discovery of six patients with 4‐hydroxybutyric acid‐uria, a severe hereditary human pathology characterized by the accumulation of a compound of known neuropharmacologic activity in body fluids. The enzymatic deficiency has been localized to succinic semialdehyde dehydrogenase, one of two enzymes involved in the ...
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AbstractRecent work has led to the discovery of six patients with 4‐hydroxybutyric acid‐uria, a severe hereditary human pathology characterized by the accumulation of a compound of known neuropharmacologic activity in body fluids. The enzymatic deficiency has been localized to succinic semialdehyde dehydrogenase, one of two enzymes involved in the ...
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, 2020 A potential new metabolite of gamma-hydroxybutyrate: sulfonated gamma-hydroxybutyric acid
International Journal of Legal Medicine, 2015Detection of gamma-hydroxybutyric acid (GHB) became crucial in many clinical and forensic settings due to its increasing use for recreational purposes and drug-facilitated sexual assault. Its narrow window of detection of about 3-12 h in urine represents a major problem. Analogous to ethyl glucuronide, the recently identified GHB-glucuronide exhibits a
Stephanie, Hanisch +2 more
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2009
Abstract Properties of Special Interest Biocompatibility and biodegradability. Biologically produced PHB is a semicrystalline isotactic stereoregular polymer of 100% R configuration that allows a high level of degradability. PHB is obtained by fermentation of bacteria capable of biosynthesizing polyesters as energy storage media.
Isao Noda +2 more
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Abstract Properties of Special Interest Biocompatibility and biodegradability. Biologically produced PHB is a semicrystalline isotactic stereoregular polymer of 100% R configuration that allows a high level of degradability. PHB is obtained by fermentation of bacteria capable of biosynthesizing polyesters as energy storage media.
Isao Noda +2 more
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Amperometric probe for 3-hydroxybutyrate with immobilized 3-hydroxybutyrate dehydrogenase
Analytica Chimica Acta, 1988Abstract The enzyme 3-hydroxybutyrate dehydrogenase is immobilized on a graphite electrode suitable for determination of NADH. Of the several procedures tested for the immobilization, direct adsorption on the electrode surface was most satisfactory, with useful lifetimes of up to 3 days.
G. Palleschi, H.S. Rathore, M. Mascini
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The Extraneural Distribution of γ‐Hydroxybutyrate
Journal of Neurochemistry, 1981Abstract— γ‐Hydroxybutyrate has been found to be widely distributed in both neural and extraneural tissues in the rat. The kidney and brown fat have more than 10 times higher concentrations of y‐hydroxybutyrate than does the brain. This observation suggests that γ‐hydroxybutyrate may participate in the metabolism of many organs, and that GABA may not ...
T, Nelson +3 more
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Biodeuteration of poly(β-hydroxybutyrate)
International Journal of Biological Macromolecules, 1992The formation of poly(beta-hydroxybutyrate), PHB, by Rhodobacter sphaeroides and Alcaligenes eutrophus was studied using the following carbon sources and solvents: (1), acetate in H2O; (2), D3-acetate in H2O; (3), acetate in 90 to 92% D2O; and (4), D3-acetate in 90 to 92% D2O. The growth of Rb.
R A, Gross +6 more
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Gamma-Hydroxybutyrate Abuse and Dependence
2016Item does not contain ...
Noorden, M.S. van +4 more
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