Results 21 to 30 of about 285 (209)

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Poly-β-hydroxybutyrate in staphylococci [PDF]

FEMS Microbiology Letters, 1992
Staphylococci--chemoorganotrophic bacteria whose main habitats are human and animal organisms--can accumulate poly-beta-hydroxybutyrate (PHB) in their cells. The polymer is metabolized in endogenous turnovers preceding degradation of aminoacids, proteins and RNA. PHB depolymerase was not found in staphylococci but beta-hydroxybutyrate dehydrogenase was
openaire   +2 more sources

The effects of the ketone body ?-hydroxybutyrate on the neuronal transcriptome

Translation
The ketogenic diet is emerging as an effective therapeutic option for patients with neurological disorders. The diet results in metabolism of fatty acids to ketone bodies like ?-hydroxybutyrates (BHBs), which serve as an alternative fuel source for ...
Zayn Cheema, Megan Chen, Dana Poon, Taara Reddy, John Vergis, Sinead O'Donovan   +5 more
doaj   +1 more source

Broad‐Spectrum, Cell Envelope‐Active Marinocyclin Antibiotics From a Coral‐Derived Bacterium Are Effective Against Colistin‐Resistant Bacteria

Angewandte Chemie, EarlyView.
Marinocyclins, polycationic macrocyclic depsipeptides, were discovered by genome mining from the marine coral‐derived bacterium Aquimarina megaterium. The compounds have broad‐spectrum activity against gram‐positive and gram‐negative ESKAPE bacteria.
Clara Chepkirui, Sandra Silva, Jan Straetener, Chandrashekhar Padhi, Tina Keller‐Costa, Tess Lamer, Laura Reinke, Heike Brötz‐Oesterhelt, Rodrigo Costa, Jörn Piel   +9 more
wiley   +2 more sources

A hypothetical mechanism capable to reflect the features of the mitochondrial permeability transition pore channel

Advances in Redox Research
Mitochondrial permeability transition pore (mPTP) channel plays a central role in cell death because it mediates the effect of a sudden large opening of the inner mitochondrial membrane.
Alexander G. Dimitrov
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Mono‐Material Polydisulfides for Pressure Sensitive Adhesive Tapes With Closed‐Loop Recyclability

Advanced Functional Materials, EarlyView.
A high‐performance pressure‐sensitive adhesive (PSA) tape is developed where both the adhesive layer and plastic backing layer can be recycled back to monomer in a closed‐loop cycle. Both layers of the tape are composed of analogous polydisulfide copolymers using only two unique monomers, thus giving it a mono‐material design and enabling recycling of ...
Woojung Ham, Tyler M. Witt, Charles M. Hui, Joshua C. Worch   +3 more
wiley   +1 more source

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source

이산화탄소와 개미산만을 이용한 재조합 대장균 내 유용 화학 물질 생산 연구

, 2021
학위논문(석사) - 한국과학기술원 : 생명화학공학과, 2021.2,[iv, 69 p. :]Increased concerns for the environmental problem related with greenhouse gases have forced bioconversion of one-carbon gases to value-added chemicals as one of the desirable solutions.
Hwang, Chang Hun
core   +1 more source

Impact du bilan énergétique sur l’inflammation génitale chez la vache laitière [PDF]

, 2015
L’objectif de cette étude est d’évaluer, sur le terrain, l’association entre les indicateurs du métabolisme énergétique et l’inflammation génitale chez la vache laitière afin de déterminer si la mesure de ces indicateurs par le praticien pourrait être un
Gros, Louise
core   +1 more source