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The effects of the ketone body ?-hydroxybutyrate on the neuronal transcriptome
TranslationThe ketogenic diet is emerging as an effective therapeutic option for patients with neurological disorders. The diet results in metabolism of fatty acids to ketone bodies like ?-hydroxybutyrates (BHBs), which serve as an alternative fuel source for ...
Zayn Cheema +5 more
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Advances in Redox ResearchMitochondrial permeability transition pore (mPTP) channel plays a central role in cell death because it mediates the effect of a sudden large opening of the inner mitochondrial membrane.
Alexander G. Dimitrov
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Baclofen and Gamma-Hydroxybutyrate Withdrawal [PDF]
Neurocritical Care, 2008 Benzodiazepine treatment of life-threatening gamma-hydroxybutyrate (GHB) withdrawal is frequently unsatisfactory. Animal studies suggest strongly that treatment with GABA(B) agonists, such as baclofen, will be a more effective strategy.A case report from the medical intensive care unit (ICU) of the university tertiary care hospital.A 61-year-old woman ...
Jennifer L, LeTourneau +2 more
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β-Hydroxybutyrate: A Signaling Metabolite [PDF]
Annual Review of Nutrition, 2017 Various mechanisms in the mammalian body provide resilience against food deprivation and dietary stress. The ketone body β-hydroxybutyrate (BHB) is synthesized in the liver from fatty acids and represents an essential carrier of energy from the liver to peripheral tissues when the supply of glucose is too low for the body's energetic needs, such as ...
John C, Newman, Eric, Verdin
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Can Small Molecules Provide Clues on Disease Progression in Cerebrospinal Fluid from Mild Cognitive Impairment and Alzheimer’s Disease Patients? [PDF]
, 2023 Alzheimer’s Disease (AD) is a complex and multifactorial neurodegenerative disease, which is currently diagnosed via clinical symptoms and non-specific biomarkers (such as Aβ1-42, t-Tau, and p-Tau) measured in cerebrospinal fluid (CSF), which alone do ...
Cheng, Tiejun +7 more
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Impact du bilan énergétique sur l’inflammation génitale chez la vache laitière [PDF]
, 2015 L’objectif de cette étude est d’évaluer, sur le terrain, l’association entre les indicateurs du métabolisme énergétique et l’inflammation génitale chez la vache laitière afin de déterminer si la mesure de ces indicateurs par le praticien pourrait être un
Gros, Louise
core
Transmembrane ion transport by polyphosphate/poly-(R)-3-hydroxybutyrate complexes [PDF]
, 2000 Inorganic polyphosphates (polyPs) and poly-(R)-3-hydroxybutyrates (PHB) are simple linear polymers that are found in a wide variety of organisms, ranging from the most primitive to the most highly evolved Polyphosphates attract and select for cations by
R N Reusch
core
, 2005 Wavelength and mass resolved resonance-enhanced two photon ionization (R2PI) excitation spectra of (R)-(+)-1-phenyl-1-propanol (P-R) and its complexes with some chiral esters, i.e.
Speranza, M. +13 more
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From the Biopolymer PHB to Biological Investigations of Unnatural ?- and ?-Peptides
CHIMIA, 2001 An overview is given of the past and present activities of our group in the field of chemical biology. Thus, the polymer of 3-hydroxybutanoic acid (PHS), which is omnipresent in living organisms, triggered our search for a better analytical ...
Dieter Seebach +4 more
doaj
Propionate analogues of zearalenone bind to Hsp90.
, 2009 By replacement of an acetate with propionate through organic synthesis a range of zearalenone analogues were prepared. As key steps in the synthesis of the analogues we used the Noyori hydrogenation of methyl acetoacetate followed by Frater alkylation of
Knapp, Stefan +14 more
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