Results 21 to 30 of about 115,105 (360)

Effect of Hydroxychloroquine in Hospitalized Patients with COVID-19

New England Journal of Medicine, 2020
Background Hydroxychloroquine and chloroquine have been proposed as treatments for coronavirus disease 2019 (COVID-19) on the basis of in vitro activity, uncontrolled data, and small randomized studies.
P. Horby, M. Mafham, L. Linsell, Jennifer L. Bell, N. Staplin, J. Emberson, M. Wiselka, A. Ustianowski, E. Elmahi, B. Prudon, T. Whitehouse, T. Felton, John Williams, Jakki Faccenda, J. Underwood, J. Baillie, L. Chappell, S. Faust, T. Jaki, K. Jeffery, W. Lim, A. Montgomery, K. Rowan, J. Tarning, J. Watson, N. White, E. Juszczak, R. Haynes, M. Landray, Recovery Collaborative Group   +29 more
semanticscholar   +1 more source

Hydroxychloroquine: a comprehensive review and its controversial role in coronavirus disease 2019

Annals of Medicine, 2021
Hydroxychloroquine, initially used as an antimalarial, is used as an immunomodulatory and anti-inflammatory agent for the management of autoimmune and rheumatic diseases such as systemic lupus erythematosus.
Pankaj Bansal, Amandeep Goyal, Austin Cusick, Shubham Lahan, Harpal S. Dhaliwal, Poonam Bhyan, Pradnya Brijmohan Bhattad, Fawad Aslam, Sagar Ranka, Tarun Dalia, Lovely Chhabra, Devang Sanghavi, Bhavin Sonani, John M. Davis   +13 more
doaj   +1 more source

Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial

British medical journal, 2020
Objective To assess the efficacy and safety of hydroxychloroquine plus standard of care compared with standard of care alone in adults with coronavirus disease 2019 (covid-19). Design Multicentre, open label, randomised controlled trial.
Wei Tang, Z. Cao, Mingfeng Han, Zhengyan Wang, Junwen Chen, Wenjin Sun, Yaojie Wu, W. Xiao, Shengyong Liu, E. Chen, Wei Chen, Xiongbiao Wang, Jiuyong Yang, Jun Lin, Qing-xia Zhao, You-qin Yan, Zhibin Xie, Dan-Qi Li, Yaofeng Yang, Leshan Liu, J. Qu, G. Ning, G. Shi, Q. Xie   +23 more
semanticscholar   +1 more source

The effect of favipiravir versus hydroxychloroquine on clinical and laboratory findings in COVID-19 in healthcare workers

Brazilian Journal of Infectious Diseases, 2022
Objectives: Comparative data on hydroxychloroquine and favipiravir, commonly used agents in the treatment of Coronavirus Disease-2019 (COVID-19), are still limited.
Derya Bayırlı Turan, Mehtap Menteş, Yıldıran Özel, Kıvanç Şerefhanoğlu, Burcu Aydoğan, Neşe İbil, Füsun Güneşdoğdu, Hijran Mammadova Orucova, Cüneyt Saltürk, Hakan Çelik   +9 more
doaj   +1 more source

A brief overview of current drug repurposing approaches for COVID-19 management [PDF]

, 2020
This brief overview is intended to shed light on the current drug repositioning (also called drug repurposing) in the therapeutics of the novel coronavirus disease which emerged in 2019 (COVID-19).
Rodrigues, Pedro da Fonseca Soares, Thomaz, Douglas Vieira   +1 more
core   +2 more sources

Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19).

JAMA cardiology, 2020
Importance Administration of hydroxychloroquine with or without azithromycin for the treatment of coronavirus disease 2019 (COVID-19)-associated pneumonia carries increased risk of corrected QT (QTc) prolongation and cardiac arrhythmias.
Nicholas J. Mercuro, C. Yen, David Shim, T. Maher, Christopher M. McCoy, P. Zimetbaum, H. Gold   +6 more
semanticscholar   +1 more source

A call to caution when hydroxychloroquine is given to elderly patients with COVID-19

International Journal of Infectious Diseases, 2021
Introduction: Use of hydroxychloroquine in patients with coronavirus disease 2019 (COVID-19) was widespread and uncontrolled until recently. Patients vulnerable to severe COVID-19 are at risk of hydroxychloroquine interactions with co-morbidities and co ...
Julian J. Gabor, Andrea Kreidenweiss, Stefan Weber, Moaaz Salama, Mihaly Sulyok, Zita Sulyok, Erik Koehne, Meral Esen, Benno Kreuels, Parichehr Shamsrizi, Erwin Biecker, Benjamin Mordmüller, Christoph P. Berg, Stefano Fusco, Carsten Köhler, Stefan Kubicka, Jens Leitlein, Marylyn Addo, Michael Ramharter, Matthias Schwab, Alfred Lennart Bissinger, Thirumalaisamy P. Velavan, Sanjeev Krishna, Peter G. Kremsner   +23 more
doaj   +1 more source

COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression

Journal of Antimicrobial Chemotherapy, 2020
A novel coronavirus disease (COVID-19), caused by infection with SARS-CoV-2, has swept across 31 provinces in China and over 40 countries worldwide. The transition from first symptoms to acute respiratory distress syndrome (ARDS) is highly likely to be ...
Dan Zhou, S. Dai, Q. Tong
semanticscholar   +1 more source

Is Hydroxychloroquine with Azithromycin a Good Combination in COVID-19 Compared to Hydroxychloroquine Alone from Cardiac Perspective? A Systematic Review and Meta-Analysis

Journal of Nepal Health Research Council, 2021
Background: The global spread of COVID-19 and the lack of definite treatment have caused an alarming crisis in the world. We aimed to evaluate the outcome and potential harmful cardiac effects of hydroxychloroquine and azithromycin compared to ...
Pravash Budhathoki, Dhan Bahadur Shrestha, Sitaram Khadka, Era Rawal   +3 more
doaj   +1 more source

Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data

British medical journal, 2020
Objective To assess the effectiveness of hydroxychloroquine in patients admitted to hospital with coronavirus disease 2019 (covid-19) pneumonia who require oxygen. Design Comparative observational study using data collected from routine care.
M. Mahévas, Viet-thi Tran, M. Roumier, A. Chabrol, R. Paule, C. Guillaud, E. Fois, Raphael Lepeule, T. Szwebel, F. Lescure, F. Schlemmer, M. Matignon, M. Khellaf, Étienne Crickx, B. Terrier, C. Morbieu, P. Legendre, J. Dang, Y. Schoindre, J. Pawlotsky, M. Michel, É. Perrodeau, Nicolas Carlier, N. Roche, V. de Lastours, Clément Ourghanlian, S. Kernéis, P. Ménager, L. Mouthon, E. Audureau, P. Ravaud, B. Godeau, S. Gallien, N. Costedoat-Chalumeau   +33 more
semanticscholar   +1 more source