Results 111 to 120 of about 927 (145)
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25-hydroxycholesterol: Gatekeeper of intestinal IgA
Immunity, 2021High levels of cholesterol and diets high in fat are associated with immune dysfunction and inflammatory disease. In this issue of Immunity, Trindade et al. (2021) report how the cholesterol metabolite 25-hydroxycholesterol restrains IgA plasma cell differentiation from germinal-center B cells in the Peyer's patches through regulation of the sterol ...
Christopher J M, Piper, Claudia, Mauri
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Synthesis of 17α-hydroxycholesterol
Steroids, 1970Abstract The known 16-dehydrocholesterol, upon treatment with a molar equivalent of m-chloroperbenzoic acid, gave in moderate yield the 16α,17α-oxido sterol. Treatment of this oxide with lithium aluminum hydride gave the desired 17α-hydroxycholesterol.
N.K. Chaudhuri, R.C. Nickolson, M. Gut
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Conversion of 20-a-hydroxycholesterol to pregnenolone
Biochemical and Biophysical Research Communications, 196120-a-Hydroxycholesterol was first reported by Solomon etal. (1956) to be an intermediate in the conversion of cholesterol to the adrenal steroids. Recently, Shimizu etal. (1960) have reported the formation of labeled isocaproic acid when 20-a-hydroxycholesterol-26-C14 was incubated with soluble adrenal extract in the presence of ATP, Mg++, DPN+, and ...
G, CONSTANTOPOULOS, T T, TCHEN
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25-Hydroxycholesterols in innate and adaptive immunity
Nature Reviews Immunology, 2014Cholesterol and components of the cholesterol biosynthetic pathway have fundamental roles in all mammalian cells. Hydroxylated forms of cholesterol are now emerging as important regulators of immune function. This involves effects on the cholesterol biosynthetic pathway and cell membrane properties, which can have antiviral and anti-inflammatory ...
Jason G, Cyster +3 more
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Lipids, 2010
AbstractDysregulation of lipid metabolism is frequently associated with inflammatory conditions. The mechanism of this association is still not clearly defined. Recently, we identified a nuclear oxysterol, 25‐hydroxycholesterol‐3‐sulfate (25HC3S), as an important regulatory molecule involved in lipid metabolism in hepatocytes.
Leyuan, Xu +6 more
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AbstractDysregulation of lipid metabolism is frequently associated with inflammatory conditions. The mechanism of this association is still not clearly defined. Recently, we identified a nuclear oxysterol, 25‐hydroxycholesterol‐3‐sulfate (25HC3S), as an important regulatory molecule involved in lipid metabolism in hepatocytes.
Leyuan, Xu +6 more
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Biochemical and Biophysical Research Communications, 2014
Familial combined hyperlipidemia (FCHL), the most common inherited disorder of lipid metabolism is characterized by increasing cholesterol synthesis precursors due to hepatic overproduction of cholesterol. The bile acids synthesis pathway has not been previously studied in FCHL.
Lucía, Baila-Rueda +6 more
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Familial combined hyperlipidemia (FCHL), the most common inherited disorder of lipid metabolism is characterized by increasing cholesterol synthesis precursors due to hepatic overproduction of cholesterol. The bile acids synthesis pathway has not been previously studied in FCHL.
Lucía, Baila-Rueda +6 more
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Cholesterol and Hydroxycholesterol in the Brain
2011The brain has higher concentration of cholesterol compared to other body parts (25% of the body’s free cholesterol) (Dietschy and Turley, 2004). In brain, cholesterol resides in two pools: one major pool associated with the myelin sheaths playing an important role in propagation of the electrical signals along the axons and the other minor pool ...
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Breast cancer and (25R)-26-hydroxycholesterol
Steroids, 2015(25R)-26-Hydroxycholesterol (27-hydroxycholesterol) has been found to accumulate in breast tissue and to stimulate tumor growth via the estrogen receptor. Although most tissues express CYP27A1, the highest levels are in macrophages and most attention had been given to the production of 27-hydroxycholesterol in sub-endothelial macrophages as part of ...
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The AAPS Journal, 2018
Cytochrome P450 3A (CYP3A) enzymes metabolize approximately half of all drugs on the market. Since the endogenous compounds 4β-hydroxycholesterol (4β-HC) and 25-hydroxycholesterol (25-HC) are generated from cholesterol via CYP3A enzymes, we examined whether the plasma levels of 4β-HC and 25-HC reflect hepatic CYP3A4 activity by using a CYP3A-humanized ...
Shin-Ichiro, Nitta +8 more
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Cytochrome P450 3A (CYP3A) enzymes metabolize approximately half of all drugs on the market. Since the endogenous compounds 4β-hydroxycholesterol (4β-HC) and 25-hydroxycholesterol (25-HC) are generated from cholesterol via CYP3A enzymes, we examined whether the plasma levels of 4β-HC and 25-HC reflect hepatic CYP3A4 activity by using a CYP3A-humanized ...
Shin-Ichiro, Nitta +8 more
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Synthesis of 25-hydroxycholesterol from bisnoralcohol
Steroids25-Hydroxycholesterol not only exhibits various important biological activities but also plays a crucial role in the synthesis of 25-hydroxyvitamin D3. To date, researchers have proposed multiple synthetic routes for 25-hydroxycholesterol. Herein, a novel synthetic method for 25-hydroxycholesterol is described, involving a seven-step reaction that ...
Bu-Luan Liang +6 more
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