Results 141 to 150 of about 2,824 (172)

Hydroxycitric acid reverses tamoxifen resistance through inhibition of ATP citrate lyase

Pathology - Research and Practice, 2022
Lipid metabolic reprogramming is involved in mediating tamoxifen (TAM) response in breast cancer cells. Published microarray data indicated that ATP citrate lyase (ACLY) is overexpressed in TAM-resistant BC cells. Hydroxycitric acid (HCA) is a powerful competitive inhibitor of the enzyme ACLY, which links carbohydrates and lipids metabolism.
Ahmed, Ismail, Hamada Ahmed, Mokhlis, Marwa, Sharaky, Mohamed H, Sobhy, Sherif S, Hassanein, Ahmed S, Doghish, Salama A, Salama, Amr D, Mariee, Yasmin M, Attia   +8 more
openaire   +2 more sources

Chemistry and Biochemistry of (−)-Hydroxycitric Acid from Garcinia

Journal of Agricultural and Food Chemistry, 2001
(-)-Hydroxycitric acid [(-)-HCA] is the principal acid of fruit rinds of Garcinia cambogia, Garcinia indica, and Garcinia atroviridis. (-)-HCA was shown to be a potent inhibitor of ATP citrate lyase (EC 4.1.3.8), which catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA: citrate + ATP + CoA --> acetyl-CoA + ADP + P(i ...
B S, Jena, G K, Jayaprakasha, R P, Singh, K K, Sakariah   +3 more
openaire   +2 more sources

Lipid-lowering and antiobesity effect of (−)hydroxycitric acid

Nutrition Research, 1988
Abstract Albino rats of Wistar strain were fed lipogenic diet with and without the addition of (−)hydroxycitrate for a period of 15 days. Daily food intake and weekly body weight gain of the animals were recorded during the feeding period. The animals were then sacrificed, blood, liver and epididymal fat were collected and analysed for selected ...
R. Nageswara Rao, K.K. Sakariah
openaire   +1 more source

Comparative effects of (−)‐hydroxycitrate and (+)‐allo‐hydroxycitrate on acetyl CoA carboxylase and fatty acid and cholesterol synthesis in vivo

Lipids, 1977
Abstract(−)‐Hydroxycitrate and (+)‐allo‐hydroxycitrate were investigated for their effects on lipid synthesis in vivo under conditions of either high carbohydrate feeding or 24 hr fasting. Changes in rates of lipid synthesis resulting from the oral administration of these compounds were monitored with the use of radiolabeled H2O, alanine, and acetate ...
J, Triscari, A C, Sullivan
openaire   +2 more sources

Glycation of aspartate aminotransferase by methylglyoxal, effect of hydroxycitric and uric acid

Molecular and Cellular Biochemistry, 2009
Glycation is a process closely related to the aging and pathogenesis of diabetic complications. Reactive alpha-dicarbonyl compounds (e.g., methylglyoxal) are formed during middle stage of glycation reaction. Compounds that would inhibit the glycation process have been seeked for years.
Iva, Bousová, Eliska, Bacílková, Sanja, Dobrijević, Jaroslav, Drsata   +3 more
openaire   +2 more sources

Capillary zone electrophorsis for the analysis of naturally occurring 2‐hydroxycitric acids and their lactones

Journal of Separation Science, 2017
A simple capillary zone electrophoresis method with direct ultraviolet detection has been developed for the analysis of naturally occurring diastereomeric 2‐hydroxycitric acid lactones. Using 50 mM sodium phosphate buffer of pH 7, a baseline resolution Rs > 3.0 was observed for all organic acids selected for the present study.
B. L. Abhijith, Moolya Mohan, David Joseph, Simimole Haleema, Hassan Y. Aboul‐Enein, Ibrahim Ibnusaud   +5 more
openaire   +2 more sources

Evaluation of the Safety and Efficacy of Hydroxycitric Acid orGarcinia cambogiaExtracts in Humans

Critical Reviews in Food Science and Nutrition, 2012
Several studies have shown that Garcinia cambogia plays an important role in the regulation of endogenous lipid biosynthesis. This effect is specially attributed to (-)-hydroxycitric acid (HCA) inhibiting the enzyme ATP-dependent citrate lyase, which catalyzes the cleavage of citrate to oxaloacetate and acetyl-CoA.
Fabiola, Márquez, Nancy, Babio, Mònica, Bulló, J, Salas-Salvadó   +3 more
openaire   +2 more sources

Absolute configurations of the naturally occurring hydroxycitric acids

Archives of Biochemistry and Biophysics, 1969
J P, Glusker, J A, Minkin, C A, Casciato, F B, Soule   +3 more
openaire   +2 more sources

Effects of (-)-hydroxycitric acid on lipid droplet accumulation in chicken embryos.

Animal science journal = Nihon chikusan Gakkaiho, 2018
This study was conducted to determine the impact of (-)-hydroxycitric acid ((-)-HCA) on biochemical indices and lipid metabolism parameters in chicken embryos. Two hundred and forty fertilized eggs were divided into six groups and injected with (-)-HCA at concentrations of 0, 0.1, 0.5, 1.0, 10.0 and 50 mg/kg (n = 40). After 19 days of incubation, serum
Mengling, Peng, Longlong, Li, Lei, Yu, Chongyang, Ge, Haitian, Ma   +4 more
openaire   +1 more source

Flotation behavior and mechanism of hydroxycitric acid as a depressant on the flotation separation of cassiterite from calcite

Minerals Engineering, 2021
Ruiqi Xie
exaly