Results 51 to 60 of about 1,201 (167)

Properties of compatible solutes in aqueous solution

, 2011
We have performed Molecular Dynamics simulations of ectoine, hydroxyectoine and urea in explicit solvent. Special attention has been spent on the local surrounding structure of water molecules.
Galla, Hans-Joachim, Harishchandra, Rakesh Kumar, Heuer, Andreas, Rubner, Oliver, Smiatek, Jens   +4 more
core   +1 more source

Cellular Viscosity in Prokaryotes and Thermal Stability of Low Molecular Weight Biomolecules [PDF]

, 2016
Prepint, Texto y GráficosSome low molecular weight biomolecules, i.e., NAD(P)H, are unstable at high temperatures. The use of these biomolecules by thermophilic microorganisms has been scarcely analyzed.
Cruces Tova, Jorge, Cuecas Morano, María de Piedras Alba, Galisteo López, Juan Francisco, Gonzáles Grau, Juan Miguel, Peng, H. X.   +4 more
core   +1 more source

Heterologous Ectoine Production in Escherichia coli: Optimization Using Response Surface Methodology

International Journal of Microbiology, Volume 2019, Issue 1, 2019., 2019
Introduction. A halophilic bacterium of the Halomonas elongata BK‐AG25 has successfully produced ectoine with high productivity. To overcome the drawbacks of high levels of salt in the production process, a nonhalophilic bacteria of Escherichia coli (E. coli) was used to express the ectoine gene cluster of the halophilic bacteria, and the production of
I Putu Parwata, Deana Wahyuningrum, Sony Suhandono, Rukman Hertadi, Giuseppe Comi   +4 more
wiley   +1 more source

Syngas biological transformation into hydroxyectoine

Bioresource Technology
Syngas from the gasification of organic wastes represents a promising feedstock for fostering a sustainable bioeconomy. However, its potential is currently constrained by the low-value products generated. Osmolytes, such as hydroxyectoine, are high-value compounds, however, their biological production as isolated osmolytes is not yet cost-effective ...
Marcos-Rodrigo, Eva, Lebrero, Raquel, Muñoz, Raúl, Sousa, Diana Z., Cantera, Sara   +4 more
openaire   +2 more sources

Compatible solutes: Ectoine and hydroxyectoine improve functional nanostructures in artificial lung surfactants

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2011
Ectoine and hydroxyectoine belong to the family of compatible solutes and are among the most abundant osmolytes in nature. These compatible solutes protect biomolecules from extreme conditions and maintain their native function. In the present study, we have investigated the effect of ectoine and hydroxyectoine on the domain structures of artificial ...
Harishchandra, Rakesh Kumar, Sachan, Amit Kumar, Kerth, Andreas, Lentzen, Georg, Neuhaus, Thorsten, Galla, Hans-Joachim   +5 more
openaire   +2 more sources

Characterization of Inter‐ and Intramolecular Interactions of Amyloid Fibrils by AFM‐Based Single‐Molecule Force Spectroscopy

Journal of Nanomaterials, Volume 2016, Issue 1, 2016., 2016
Amyloids are fibrous protein aggregates defined by shared specific structural features. Abnormal accumulation of amyloid in organs leads to amyloidosis, which results in various neurodegenerative diseases. Atomic force microscopy (AFM) has proven to be an excellent tool investigating amyloids; it has been extensively utilized to characterize its ...
Yinli Li, Hao Liang, Huiling Zhao, Dong Chen, Bo Liu, Thomas Fuhs, Mingdong Dong, Meiyong Liao   +7 more
wiley   +1 more source

Metabolites Associated with Adaptation of Microorganisms to an Acidophilic, Metal-Rich Environment Identified by Stable-Isotope-Enabled Metabolomics

mBio, 2013
Microorganisms grow under a remarkable range of extreme conditions. Environmental transcriptomic and proteomic studies have highlighted metabolic pathways active in extremophilic communities.
Annika C. Mosier, Nicholas B. Justice, Benjamin P. Bowen, Richard Baran, Brian C. Thomas, Trent R. Northen, Jillian F. Banfield   +6 more
doaj   +1 more source

Adipose‐derived stem cells and keratinocytes in a chronic wound cell culture model: the role of hydroxyectoine

International Wound Journal, Volume 12, Issue 4, Page 387-396, August 2015., 2015
Abstract Chronic wounds represent a major socio‐economic problem in developed countries today. Wound healing is a complex biological process. It requires a well‐orchestrated interaction of mediators, resident cells and infiltrating cells. In this context, mesenchymal stem cells and keratinocytes play a crucial role in tissue regeneration.
Oliver C Thamm, Panagiotis Theodorou, Ewa Stuermer, Max J Zinser, Edmund A Neugebauer, Paul C Fuchs, Paola Koenen   +6 more
wiley   +1 more source

Ectoine alters subcellular localization of inclusions and reduces apoptotic cell death induced by the truncated Machado–Joseph disease gene product with an expanded polyglutamine stretch

Neurobiology of Disease, 2005
Protein misfolding is considered a key event in the pathogenesis of polyglutamine disease such as Machado–Joseph disease (MJD). Overexpression of chaperone proteins and the application of chemical chaperones are reported to suppress polyglutamine induced
Kentaro Furusho, Toshihiro Yoshizawa, Shinichi Shoji   +2 more
doaj   +1 more source

A Honey Trap for the Treatment of Acne: Manipulating the Follicular Microenvironment to Control Propionibacterium acnes

BioMed Research International, Volume 2013, Issue 1, 2013., 2013
Today, as 40 years ago, we still rely on a limited number of antibiotics and benzoyl peroxide to treat inflammatory acne. An alternative way of suppressing the growth of Propionibacterium acnes is to target the environment in which it thrives. We conjecture that P.
E. Anne Eady, Alison M. Layton, Jonathan H. Cove, Peter A. Lambert   +3 more
wiley   +1 more source