Results 91 to 100 of about 5,905,176 (286)

Changes in erythrocyte membrane epoxyeicosatrienoic, dihydroxyeicosatrienoic, and hydroxyeicosatetraenoic acids during pregnancy. [PDF]

Life Sci, 2021
Somani ST, Zeigler M, Fay EE, Leahy M, Bermudez B, Totah RA, Hebert MF.   +6 more
europepmc   +1 more source

Serum metabolic signatures of primary biliary cirrhosis and primary sclerosing cholangitis [PDF]

, 2014
BACKGROUND & AIMS: A greater understanding of cholestatic disease is necessary to advance diagnostic tools and therapeutic options for conditions such as primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC).
Bell, Lauren N., Chalasani, Naga, Comerford, Megan, Vuppalanchi, Raj, Wulff, Jacob   +4 more
core   +1 more source

Arachidonic acid metabolism as a therapeutic target in AKI-to-CKD transition

Frontiers in Pharmacology
Arachidonic acid (AA) is a main component of cell membrane lipids. AA is mainly metabolized by three enzymes: cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 (CYP450).
Xiao-Jun Li, Xiao-Jun Li, Ping Suo, Yan-Ni Wang, Liang Zou, Xiao-Li Nie, Ying-Yong Zhao, Hua Miao   +7 more
doaj   +1 more source

Vascular endothelial overexpression of human CYP2J2 (Tie2-CYP2J2 Tr) modulates cardiac oxylipin profiles and enhances coronary reactive hyperemia in mice.

PLoS ONE, 2017
Arachidonic acid is metabolized to epoxyeicosatrienoic acids (EETs) by cytochrome (CYP) P450 epoxygenases, and to ω-terminal hydroxyeicosatetraenoic acids (HETEs) by ω-hydroxylases.
Ahmad Hanif, Matthew L Edin, Darryl C Zeldin, Christophe Morisseau, John R Falck, Mohammed A Nayeem   +5 more
doaj   +1 more source

EDHF: An update [PDF]

, 2009
The endothelium controls vascular tone not only by releasing NO and prostacyclin, but also by other pathways causing hyperpolarization of the underlying smooth muscle cells.
Félétou, M, VanHoutte, PM
core   +1 more source

Obesity dependent metabolic signatures associated with nonalcoholic fatty liver disease progression [PDF]

, 2012
Our understanding of the mechanisms by which nonalcoholic fatty liver disease (NAFLD) progresses from simple steatosis to steatohepatitis (NASH) is still very limited.
Alonso, C, Barr, J, Caballería, J, Domínguez-Díez, A, Martínez Arranz, Ibon, Moto, J.M., Muntané Relat, Jordi, Romero Gómez, Manuel   +7 more
core  

Resolution of inflammation in obesity-induced liver disease [PDF]

, 2012
Low-grade inflammation in adipose tissue is recognized as a critical event in the development of obesity-related co-morbidities. This chronic inflammation is powerfully augmented through the infiltration of macrophages, which together with adipocytes ...
Ana González-Périz, Bibiana Rius, Cristina López-Vicario, Esther Titos, Eva Morán-Salvador, Joan Clária, Verónica García-Alonso   +6 more
core   +1 more source

Profiling lipid mediators in serum from children with H1N1 influenza

Scientific Reports
Influenza A virus subtype H1N1 can cause severe acute respiratory distress syndrome and death in young children and elderly individuals. H1N1 initiates inflammatory responses that aim to contain and eliminate microbial invaders.
Weijun Chen, Yitao Gu, Yongjun Ma, Lele Dong, Liangxuan Pan, Chai Ji, Lanlan Guo, Lianxin Qi, Yuanyuan Zhang, Fei Gao   +9 more
doaj   +1 more source

Profile of Arachidonic Acid-Derived Inflammatory Markers and Its Modulation by Nitro-Oleic Acid in an Inherited Model of Amyotrophic Lateral Sclerosis

Frontiers in Molecular Neuroscience, 2018
The lack of current treatments for amyotrophic lateral sclerosis (ALS) highlights the need of a comprehensive understanding of the biological mechanisms of the disease.
Andrés Trostchansky, Andrés Trostchansky, Mauricio Mastrogiovanni, Mauricio Mastrogiovanni, Ernesto Miquel, Ernesto Miquel, Sebastián Rodríguez-Bottero, Sebastián Rodríguez-Bottero, Laura Martínez-Palma, Laura Martínez-Palma, Patricia Cassina, Patricia Cassina, Homero Rubbo, Homero Rubbo   +13 more
doaj   +1 more source

METHOD FOR MODULATING EICOSANOID MEDIATED IMMUNE RESPONSES IN ARTHROPODS [PDF]

, 2000
The invention is directed to compositions which alter the health of invertebrate organisms by affecting eicosanoid mediated immune responses, and methods of using the compositions.
Stanley, David W.
core   +1 more source