Results 71 to 80 of about 5,706 (177)

Arachidonic acid metabolism as a therapeutic target in AKI-to-CKD transition

Frontiers in Pharmacology
Arachidonic acid (AA) is a main component of cell membrane lipids. AA is mainly metabolized by three enzymes: cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 (CYP450).
Xiao-Jun Li, Xiao-Jun Li, Ping Suo, Yan-Ni Wang, Liang Zou, Xiao-Li Nie, Ying-Yong Zhao, Hua Miao   +7 more
doaj   +1 more source

Profiling lipid mediators in serum from children with H1N1 influenza

Scientific Reports
Influenza A virus subtype H1N1 can cause severe acute respiratory distress syndrome and death in young children and elderly individuals. H1N1 initiates inflammatory responses that aim to contain and eliminate microbial invaders.
Weijun Chen, Yitao Gu, Yongjun Ma, Lele Dong, Liangxuan Pan, Chai Ji, Lanlan Guo, Lianxin Qi, Yuanyuan Zhang, Fei Gao   +9 more
doaj   +1 more source

Vascular endothelial overexpression of human CYP2J2 (Tie2-CYP2J2 Tr) modulates cardiac oxylipin profiles and enhances coronary reactive hyperemia in mice.

PLoS ONE, 2017
Arachidonic acid is metabolized to epoxyeicosatrienoic acids (EETs) by cytochrome (CYP) P450 epoxygenases, and to ω-terminal hydroxyeicosatetraenoic acids (HETEs) by ω-hydroxylases.
Ahmad Hanif, Matthew L Edin, Darryl C Zeldin, Christophe Morisseau, John R Falck, Mohammed A Nayeem   +5 more
doaj   +1 more source

Fecal Lipid Metabolites and Microbiota Alterations in Dogs With Concurrent Atopic Dermatitis and Adverse Food Reaction

Allergy, Volume 81, Issue 7, Page 2549-2552, July 2026.
Akane Hayashi, Sayaka Kakiyama, Koji Kawano, Naomi Harima‐Mizusawa, Toshihide Kobayashi, Chiaki Kaga, Koji Kobayashi, Takahisa Murata   +7 more
wiley   +1 more source

Profile of Arachidonic Acid-Derived Inflammatory Markers and Its Modulation by Nitro-Oleic Acid in an Inherited Model of Amyotrophic Lateral Sclerosis

Frontiers in Molecular Neuroscience, 2018
The lack of current treatments for amyotrophic lateral sclerosis (ALS) highlights the need of a comprehensive understanding of the biological mechanisms of the disease.
Andrés Trostchansky, Andrés Trostchansky, Mauricio Mastrogiovanni, Mauricio Mastrogiovanni, Ernesto Miquel, Ernesto Miquel, Sebastián Rodríguez-Bottero, Sebastián Rodríguez-Bottero, Laura Martínez-Palma, Laura Martínez-Palma, Patricia Cassina, Patricia Cassina, Homero Rubbo, Homero Rubbo   +13 more
doaj   +1 more source

The simultaneous quantification of cytochrome P450 dependent linoleate and arachidonate metabolites in urine by HPLC-MS/MS

Journal of Lipid Research, 2002
A method for the simultaneous quantification of urinary linoleic and arachidonic acid derived epoxides and diols, as well as the arachidonate omega hydroxylated product has been developed. The method employs negative mode electrospray ionization and HPLC
John W. Newman, Takaho Watanabe, Bruce D. Hammock   +2 more
doaj   +1 more source

High intake of n-6 polyunsaturated fatty acid exacerbates non-alcoholic steatohepatitis by the involvement of multiple metabolic pathways

Frontiers in Nutrition
Non-alcoholic steatohepatitis (NASH) is characterized by steatosis, inflammation, and hepatocyte damage. A Western-style diet characterized by excessive n-6 polyunsaturated fatty acid (n-6 PUFA) intake, which is metabolized to pro-inflammatory ...
Jian-Tong, Meng-Ting Zhou, Xiang-Zhun Song, Liu Yang, Yu-Hui Fang, Lan Liu, Jing-Shu Cui, Xiao-Chen Lu, Hai-Yang Zhu, Ying-Bin Jin, Hong-Mei Han   +10 more
doaj   +1 more source

Cell–Cell Interaction of Macrophages and Vascular Smooth Muscle Cells in the Synthesis of Leukotriene B4

Mediators of Inflammation, 1994
Biosynthesis of LTB4 during cell-cell interaction between vascular smooth muscle cells (SMC) and alveolar macrophages (AM) has been investigated by use of both high-pressure Hquid chromatography (HPLC) and radtoimmunoassay (RIA). Both interleukin-β (IL-β)
M. Zou, C. Anges
doaj   +1 more source

5-Hydroxyeicosatetraenoic Acid [PDF]

, 2020
openaire   +1 more source

Intestinal IFNα4 promotes 15-HETE diet-induced pulmonary hypertension

Respiratory Research
Objectives Pulmonary arterial hypertension (PAH) is characterized by the remodeling of the pulmonary vascular bed leading to elevation of the pulmonary arterial pressure.
Grégoire Ruffenach, Lejla Medzikovic, Laila Aryan, Wasila Sun, Long Lertpanit, Ellen O’Connor, Ateyeh Dehghanitafti, Mohammad Reza Hatamnejad, Min Li, Srinivasa T. Reddy, Mansoureh Eghbali   +10 more
doaj   +1 more source