Results 31 to 40 of about 132 (117)

The catechol estrogen, 4-hydroxyestrone, has tissue-specific estrogen actions [PDF]

Journal of Endocrinology, 2000
Recent data indicate that the catechol estrogen, 2-hydroxyestrone (2-OHE(1)), has no effect on any target tissue including bone, whereas 16 alpha-hydroxyestrone (16 alpha-OHE(1)) exerts tissue-selective estrogen agonist activity. The effect of the catechol estrogen, 4-hydroxyestrone (4-OHE(1)), putatively associated with tumorigenesis, has not been ...
K C, Westerlind, K J, Gibson, G L, Evans, R T, Turner   +3 more
openaire   +2 more sources

Prediction of Fragmentation Pathway of Natural Products, Antibiotics, and Pesticides by ChemFrag

Journal of Mass Spectrometry, Volume 60, Issue 5, May 2025.
ABSTRACT Because the manual interpretation of ESI‐MSn fragmentation spectra is time‐consuming and usually requires expert knowledge, automated annotation is often sought. The fragmentation software ChemFrag enables the annotation of MSn spectra by combining a rule‐based fragmentation and a semiempirical quantum chemical approach.
Jördis‐Ann Schüler, Annemarie E. Kramell, Antonia Schmidt, Pauline D. Walesch, René Csuk   +4 more
wiley   +1 more source

Predictors of the plasma ratio of 2-hydroxyestrone to 16alpha-hydroxyestrone among pre-menopausal, nulliparous women from four ethnic groups [PDF]

Carcinogenesis, 2003
Studies of circulating estrogen levels in relation to pre-menopausal breast cancer risk have yielded inconsistent results. Various estrogen metabolites might affect the risk differently. Estradiol metabolism occurs primarily via two mutually exclusive pathways, yielding 2-hydroxyestrone (2-OHE) and 16alpha-hydroxyestrone (16alpha-OHE).
H, Jernström, T L, Klug, D W, Sepkovic, H L, Bradlow, S A, Narod   +4 more
openaire   +2 more sources

Pulmonary Hypertension: Molecular Mechanisms and Clinical Studies

MedComm, Volume 6, Issue 3, March 2025.
The figure highlights the interplay of genetic and epigenetic mechanisms in pulmonary hypertension (PH) and their implications for therapeutic strategies. The genetic mechanism section features key genes implicated in PH pathogenesis. The epigenetic mechanism encompasses DNA methylation, RNA methylation, noncoding RNAs (miRNA, lncRNA), and histone ...
Joseph Adu‐Amankwaah, Qiang You, Xiaoer Liu, Jiayi Jiang, Dongqi Yang, Kuntao Liu, Jinxiang Yuan, Yanfang Wang, Qinghua Hu, Rubin Tan   +9 more
wiley   +1 more source

Halophyte‐based crop managements induce biochemical, metabolomic and proteomic changes in tomato plants under saline conditions

Physiologia Plantarum, Volume 177, Issue 1, January/February 2025.
Abstract Halophytes display distinctive physiological mechanisms that enable their survival and growth under extreme saline conditions. This makes them potential candidates for their use in saline agriculture. In this research, tomato (Solanum lycopersium Mill.) was cultivated in moderately saline conditions under two different managements involving ...
Gregorio Barba‐Espín, Carmen Jurado‐Mañogil, Zuzana Plskova, Pavel I. Kerchev, José A. Hernández, Pedro Diaz‐Vivancos   +5 more
wiley   +1 more source

Profiling of urinary steroids aided by lithium ion adduction‐based ultrahigh‐performance liquid chromatography–tandem mass spectrometry

Rapid Communications in Mass Spectrometry, Volume 38, Issue 9, 15 May 2024.
Rationale As 3‐OH‐containing steroids are prone to dehydration by conventional electrospray ionization, reducing detection sensitivity, Li ion adduction‐based ultrahigh‐performance liquid chromatography–tandem mass spectrometry (UHPLC/MS/MS), developed to prevent dehydration and effectively detect 3‐OH steroids, was applied for profiling total and free
Yue Pan, Qiuyi Wang, Mengyao Chen, Toshifumi Takao   +3 more
wiley   +1 more source

Pulmonary arterial hypertension: Sex matters

British Journal of Pharmacology, Volume 181, Issue 7, Page 938-966, April 2024.
▪▪ Pulmonary arterial hypertension (PAH) is a complex disease of multifactorial origin. While registries have demonstrated that women are more susceptible to the disease, females with PAH have superior right ventricle (RV) function and a better prognosis than their male counterparts, a phenomenon referred to as the ‘estrogen paradox’.
Joshua P. Dignam, Smriti Sharma, Ioannis Stasinopoulos, Margaret R. MacLean   +3 more
wiley   +1 more source

Quantifying estrogen metabolism: an evaluation of the reproducibility and validity of enzyme immunoassays for 2-hydroxyestrone and 16alpha-hydroxyestrone in urine.

Environmental Health Perspectives, 1997
Rapid and simple enzyme immunoassays (EIAs) were recently developed to measure 2-hydroxyestrone and 16alpha-hydroxyestrone in unextracted urine. The balance between these competing estrogen metabolism pathways may serve as a biomarker of breast cancer risk.
R G, Ziegler, S C, Rossi, T R, Fears, H L, Bradlow, H, Adlercreutz, D, Sepkovic, P, Kiuru, K, Wahala, J B, Vaught, J L, Donaldson, R T, Falk, C M, Fillmore, P K, Siiteri, R N, Hoover, M H, Gail   +14 more
openaire   +2 more sources

Syntheses of 15α-Hydroxyestrone and 15α-Hydroxyestradiol

Chemical and Pharmaceutical Bulletin, 1975
The titled compounds (1, 2) have been prepared from estrone by the new synthetic routes. Introduction of a hydroxyl group into the 15α-position was readily attained by hydroboration of the 14, 15-or 15, 16-double bond with diborane and subsequent oxidation of the organoborane with alkaline hydrogen peroxide.
HIROSHI HOSODA, KOUWA YAMASHITA, TOSHIO NAMBARA   +2 more
openaire   +2 more sources

In vitro O-methylation of 4-hydroxyestrone monosulfates.

Journal of Pharmacobio-Dynamics, 1982
In vitro O-methylation of 4-hydroxyestrone monosulfates has been examined by means of high-performance liquid chromatography with electrochemical detection. When 4-hydroxyestrone or its 3-sulfate was incubated with rat liver homogenate in the presence of S-adenosyl-L-methionine, the 4-methyl ether was formed in twelve times larger amount than the 3 ...
K, Shimada, Y, Yumura, T, Nambara
openaire   +3 more sources