Results 31 to 40 of about 154 (134)

The estrobolome: Estrogen‐metabolizing pathways of the gut microbiome and their relation to breast cancer

International Journal of Cancer, Volume 157, Issue 4, Page 599-613, 15 August 2025.
Abstract Increasing evidence links the gut microbiome to carcinogenesis. Disruptions in estrogen regulation by the estrobolome—gut microbiota with estrogen‐related functions—may promote breast cancer. However, precise information on estrobolome targets and their underlying mechanisms is limited. This review identifies relevant targets for measuring the
Ashley H. Larnder, Amee R. Manges, Rachel A. Murphy   +2 more
wiley   +1 more source

Predictors of the plasma ratio of 2-hydroxyestrone to 16alpha-hydroxyestrone among pre-menopausal, nulliparous women from four ethnic groups [PDF]

Carcinogenesis, 2003
Studies of circulating estrogen levels in relation to pre-menopausal breast cancer risk have yielded inconsistent results. Various estrogen metabolites might affect the risk differently. Estradiol metabolism occurs primarily via two mutually exclusive pathways, yielding 2-hydroxyestrone (2-OHE) and 16alpha-hydroxyestrone (16alpha-OHE).
H, Jernström, T L, Klug, D W, Sepkovic, H L, Bradlow, S A, Narod   +4 more
openaire   +2 more sources

Prediction of Fragmentation Pathway of Natural Products, Antibiotics, and Pesticides by ChemFrag

Journal of Mass Spectrometry, Volume 60, Issue 5, May 2025.
ABSTRACT Because the manual interpretation of ESI‐MSn fragmentation spectra is time‐consuming and usually requires expert knowledge, automated annotation is often sought. The fragmentation software ChemFrag enables the annotation of MSn spectra by combining a rule‐based fragmentation and a semiempirical quantum chemical approach.
Jördis‐Ann Schüler, Annemarie E. Kramell, Antonia Schmidt, Pauline D. Walesch, René Csuk   +4 more
wiley   +1 more source

Pulmonary Hypertension: Molecular Mechanisms and Clinical Studies

MedComm, Volume 6, Issue 3, March 2025.
The figure highlights the interplay of genetic and epigenetic mechanisms in pulmonary hypertension (PH) and their implications for therapeutic strategies. The genetic mechanism section features key genes implicated in PH pathogenesis. The epigenetic mechanism encompasses DNA methylation, RNA methylation, noncoding RNAs (miRNA, lncRNA), and histone ...
Joseph Adu‐Amankwaah, Qiang You, Xiaoer Liu, Jiayi Jiang, Dongqi Yang, Kuntao Liu, Jinxiang Yuan, Yanfang Wang, Qinghua Hu, Rubin Tan   +9 more
wiley   +1 more source

Halophyte‐based crop managements induce biochemical, metabolomic and proteomic changes in tomato plants under saline conditions

Physiologia Plantarum, Volume 177, Issue 1, January/February 2025.
Abstract Halophytes display distinctive physiological mechanisms that enable their survival and growth under extreme saline conditions. This makes them potential candidates for their use in saline agriculture. In this research, tomato (Solanum lycopersium Mill.) was cultivated in moderately saline conditions under two different managements involving ...
Gregorio Barba‐Espín, Carmen Jurado‐Mañogil, Zuzana Plskova, Pavel I. Kerchev, José A. Hernández, Pedro Diaz‐Vivancos   +5 more
wiley   +1 more source

Profiling of urinary steroids aided by lithium ion adduction‐based ultrahigh‐performance liquid chromatography–tandem mass spectrometry

Rapid Communications in Mass Spectrometry, Volume 38, Issue 9, 15 May 2024.
Rationale As 3‐OH‐containing steroids are prone to dehydration by conventional electrospray ionization, reducing detection sensitivity, Li ion adduction‐based ultrahigh‐performance liquid chromatography–tandem mass spectrometry (UHPLC/MS/MS), developed to prevent dehydration and effectively detect 3‐OH steroids, was applied for profiling total and free
Yue Pan, Qiuyi Wang, Mengyao Chen, Toshifumi Takao   +3 more
wiley   +1 more source

Cardiovascular disease among diabetic women with bilateral oophorectomy. [PDF]

, 2013
Cardiovascular Disease (CVD) is the leading cause of death in women and the risk is increased threefold in diabetics. In postmenopausal diabetics, the ovary responds to hyperinsulinemia by increasing secretion of testosterone precursors which increases ...
Appiah, Duke
core   +1 more source

Pulmonary arterial hypertension: Sex matters

British Journal of Pharmacology, Volume 181, Issue 7, Page 938-966, April 2024.
▪▪ Pulmonary arterial hypertension (PAH) is a complex disease of multifactorial origin. While registries have demonstrated that women are more susceptible to the disease, females with PAH have superior right ventricle (RV) function and a better prognosis than their male counterparts, a phenomenon referred to as the ‘estrogen paradox’.
Joshua P. Dignam, Smriti Sharma, Ioannis Stasinopoulos, Margaret R. MacLean   +3 more
wiley   +1 more source

Sex differences in structural cell‐mediated immune regulation: Implications for precision respiratory medicine

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
Quocdai Vu, Wei Gao, Wujian Xu, Ximing Liao, Qiang Li   +4 more
wiley   +1 more source

The effects of diet and geographic ancestry on drug-metabolising enzyme activity in Europeans and South Asians [PDF]

, 2018
Drug metabolism is a major determinant of variability in response to medicines. The effects of genetics and diet on cytochrome P450 (CYP) activity differ between geographic ancestries.
Eagles, Shane Kenneth
core