Results 51 to 60 of about 8,352 (265)

Oxy-imino saccharidic derivatives as a new structural class of aldose reductase inhibitors endowed with anti-oxidant activity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Aldose reductase is a key enzyme in the development of long term diabetic complications and its inhibition represents a viable therapeutic solution for people affected by these pathologies.
Felicia D'Andrea, Stefania Sartini, Ilaria Piano, Matteo Franceschi, Luca Quattrini, Lorenzo Guazzelli, Lidia Ciccone, Elisabetta Orlandini, Claudia Gargini, Concettina La Motta, Susanna Nencetti   +10 more
doaj   +1 more source

Oxidation of aliphatic hydroxylamines in aqueous solutions [PDF]

, 1977
The effects of pH, buffer constituents, duration of storage, presence of air, heavy metal ions, extracting solvents and various additives and cofactors on the aerial oxidation of some aliphatic primary and secondary hydroxylamines were investigated ...
A Rashid Purkaystha, A H Beckett, P H Morgan   +2 more
core   +1 more source

Stabilized Bi(III) Sites Direct *NH2OH Pathway for Efficient Cyclohexanone Oxime Electrosynthesis

Advanced Materials, EarlyView.
The electron‐buffering effect stabilizes Bi3+ sites under electroreductive conditions, preserving a favorable interfacial water configuration that sustains the selective *NH2OH pathway and enables efficient cyclohexanone oxime electrosynthesis. ABSTRACT Coupling electrocatalytic nitrite reduction reaction (NO2−RR) with cyclohexanone conversion enables ...
Zichao Xi, Yan Du, Haijing Li, Jian Shang, Jinxiao Wu, Peng Li, Huimin Yu, Tianyi Ma, Huanyu Jin   +8 more
wiley   +1 more source

Irreversible Rearrangement of Silyl Groups between Oxygen and Nitrogen in Tris(silyl)hydroxylamines [PDF]

, 2016
Diorganofluorosilylation of 1,2-bis(trimethylsilyl)hydroxylamines at low temperatures gives exclusively O-(diorganofluorosilyl)-N,N-bis(trimethylsilyl)hydroxylamines 1a,b.
Thomas Müller (3554), Uwe Klingebiel (2981694), Regine Wolfgramm (3085779)   +2 more
core   +1 more source

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

Improvement of film quality and solar cell properties of perovskite by the addition of N-benzylhydroxylamine

Applied Physics Express
In this study on perovskite solar cells (PVSCs), we incorporate N-benzylhydroxylamine (N-BzHoA) as an additive into the precursor solution. The addition of N-BzHoA suppressed the formation of unwanted PbI _2 and δ-phase perovskite without affecting the ...
Keisuke Nagasawa, Takeshi Sano, Viet Nguyen Chau, Yutaka Okuyama, Yuya Sayama, Ryosuke Oikawa, Keigo Hoshi, Takayuki Chiba, Junji Kido   +8 more
doaj   +1 more source

Synthetic Chameleon Turns into Oximes, Nitrones, and Hydroxylamines when Exposed to Blue Light [PDF]

ACS Omega
Michaela Marčeková, Ol’ga Caletková, Radka Kalníková, Miroslava Litecká, Ján Moncol’, Pavol Jakubec   +5 more
doaj   +2 more sources

Nitrones and oxaziridines. XXII. Preparation and cyclization of some δ,ε-unsaturated hydroxylamines [PDF]

, 1978
Four δ,ε-unsaturated hydroxylamines have been prepared by reduction of the related oximes by sodium cyanoborohydride. Only two of these-those containing terminal olefinic groups-undergo spontaneous cyclization to N-hydroxypyrrolidines, which can be ...
JE Doyle, DSC Black
core   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Palladium catalyzed N-arylation of hydroxylamines [PDF]

, 2009
Over the past decade modified Ullmann couplings and palladium-catalyzed arylations of nitrogen contg. compds. (Buchwald-Hartwig aminations) have emerged as powerful tools in synthetic chem. Interestingly, despite their biol.
Tomkinson, Nicholas C. O., Porzelle, Achim   +1 more
core