Results 121 to 130 of about 66,526 (244)

Liver X Receptor α (LXRα) Regulates 5β‐Reductase (AKR1D1) Expression in Avian Embryos: Implications for Yolk Steroid Metabolism

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Steroid‐mediated maternal effects are well‐studied as a source of phenotypic variation. In bird eggs, the yolk contains various steroids that can influence embryonic development. However, one complicating factor in understanding how yolk steroids affect development is that the embryo metabolizes yolk steroids to regulate exposure.
Ryan T. Paitz, Sara E. Waters, Delaney K. Reynolds, Emily M. Drew, Emily P. Harders   +4 more
wiley   +1 more source

Engineering a cytochrome P450 enzyme as a peroxygenase for selective hydroxylation of steroids. [PDF]

Nat Commun
Tang T, Wang R, Chen Y.
europepmc   +1 more source

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, EarlyView.
Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

Regioselective Sesquiterpene Hydroxylation Directed by Tunnel Remodeling in Rieske Oxygenases. [PDF]

JACS Au
Berger JB, Marques SM, Wissner JL, Schelle JT, Beekwilder J, Damborsky J, Hauer B.   +6 more
europepmc   +1 more source

Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‐Driven Pathology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley   +1 more source

GNPS Feature-Based Molecular Networking as a Tool to Visualize Metabolic Toxicity from Drug-Drug Interactions: A Case Study with Methamphetamine and Ethanol. [PDF]

Anal Chem
Kim M, Kim JH, Yoo SJ, Lee S.
europepmc   +1 more source

Study on Phase I Metabolic Processes and Metabolite Biomarker Identification of Synthetic Cannabinoids 5F-ADB-PINACA and 5F-ADBICA in Human Liver Microsomes and Zebrafish Model. [PDF]

Molecules
Li H, Zheng H, Zhong S, Zhao Y, Lin J, Su H, Qian Z, Wang Y.   +7 more
europepmc   +1 more source

GameXPeptide synergistically enhances the control efficiency of Metarhizium anisopliae by inhibiting cotton aphid immunity

New Plant Protection, EarlyView.
In this research, GXP serves as a potent synergist for Metarhizium anisopliae in controlling cotton aphids. Its synergistic effect is achieved through two key mechanisms: first, by downregulating melanization protease 1 expression to inhibit phenoloxidase activity, thereby suppressing melanization; second, by reducing hypoxanthine levels, which ...
Xianfeng Yin, Xin Sun, Fenglian Jia, Shiqian Feng, Rong Zhang, Hidayat Ullah, Fulian Wang, Guangyue Li, Xiongbing Tu   +8 more
wiley   +1 more source

Effect of Cytochrome P450 2C9 genetic polymorphism on agomelatine metabolism <i>in vitro</i>. [PDF]

PeerJ
Fang P, Ni J, Shen T, Chen Q, Ye X, Jin J, Dai D, Hu G, Qian J, Cai J, Chen L.   +10 more
europepmc   +1 more source

Modifying Antibiotic Activity of Synthetic Thiadiazine Analogs Against MDR Bacteria and ADMET Analysis

ChemistryOpen, EarlyView.
The study demonstrated that thidiazine compounds potentiated the action of antibiotics. The compounds associated with norfloxacin against S. aureus showed greater significance in relation to the other medications. The indiscriminate use of antibiotics has led to the selection of resistant bacterial strains, significantly reducing the effectiveness of ...
João Arthur de Oliveira Borges, Priscilla Ramos Freitas, Isaac Moura Araújo, Ray Silva de Almeida, Igor José dos Santos Nascimento, João Xavier de Araújo‐Júnior, Edeildo Ferreira da Silva‐Júnior, Thiago Mendonça de Aquino, Francisco Jaime Bezerra Mendonça Junior, Emmanuel Silva Marinho, Hélcio Silva dos Santos, Radosław Kowalski, Grażyna Kowalska, Henrique Douglas Melo Coutinho, Saulo Relison Tintino, Ana Carolina Justino de Araújo   +15 more
wiley   +1 more source