Results 121 to 130 of about 111,305 (353)
Angewandte Chemie International Edition, Accepted Article.This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley +1 more source
Biosynthesis of the Red Algal Diterpene Peyssonnosol in Bacteria
Angewandte Chemie International Edition, EarlyView.Two terpene synthases derived from Anaerolineae bacteria catalyse the biosynthesis of peyssonnosene‐type diterpenes from red algae. Site‐directed mutagenesis enabled a partial functional switch, resulting in the formation of additional byproducts. The intricate cyclisation mechanisms were investigated through isotopic labelling experiments and density ...
Zhiyong Yin +10 more
wiley +1 more source
ENZYMATIC HYDROXYLATION OF BENZOPYRENE AND ITS RELATIONSHIP TO CYTOTOXICITY [PDF]
, 1969 Harry V. Gelboin +2 more
openalex +1 more source
Porous Organic Cages as Building Blocks for Framework Materials
Angewandte Chemie International Edition, Accepted Article.Confined nanospaces play a fundamental role in nature, inspiring synthetic analogues that emulate biological precision and efficiency. Among these, porous crystalline materials such as covalent organic frameworks (COFs), metal‐organic frameworks (MOFs), and molecular cage compounds have emerged as powerful platforms for catalysis, separation, and ...
Marcos Martínez-Fernández +2 more
wiley +1 more source
Nuclear Hydroxylations of Aromatic Compounds
, 1958 Zen‐ichi Yoshida, Seizi Sagawa
openalex +2 more sources
Deciphering Tryptophan Oxygenation: Key Modulators of 2‐Oxindole Formation in MarE
Angewandte Chemie International Edition, Accepted Article.MarE, a heme‐dependent aromatic oxygenase with a histidyl axial ligated, catalyzes the monooxygention of β‐methyl‐L‐tryptophan, to form a 2‐oxindole scaffold central to maremycin biosynthesis. Although structurally similar to tryptophan 2,3‐dioxygenase (TDO), which initiates L‐tryptophan catabolism via dioxygenation, MarE exhibits distinct reactivity ...
Romie C. Nguyen, Inchul Shin, Aimin Liu
wiley +1 more source
Further Studies on the Phenylalanine-hydroxylation Cofactor
, 1959 Seymour Kaufman, Bruce Levenberg
openalex +1 more source
The enzymic hydroxylation of protocollagen models [PDF]
, 1969 Y. Kikuchi +2 more
openalex +1 more source