Resonance Raman Spectroscopy of the Oxygenated Intermediates of Human CYP19A1 Implicates a Compound I Intermediate in the Final Lyase Step [PDF]
, 2014 CYP19A1, or aromatase, a cytochrome P450 responsible for estrogen biosynthesis in humans, is an important therapeutic target for the treatment of breast cancer.
Kincaid, James R. +3 more
core +2 more sources
Catalysts on Demand: Selective Oxidations by Laboratory-Evolved Cytochrome P450 BM3 [PDF]
, 2009 Efficient catalysts for selective oxidation of C-H bonds using atmospheric oxygen are highly desirable to decrease the economic and environmental costs associated with conventional oxidation processes.
Arnold, Frances H., Lewis, Jared C.
core +2 more sources
Two-Component FAD-Dependent Monooxygenases: Current Knowledge and Biotechnological Opportunities
Biology, 2018 Flavoprotein monooxygenases create valuable compounds that are of high interest for the chemical, pharmaceutical, and agrochemical industries, among others. Monooxygenases that use flavin as cofactor are either single- or two-component systems.
Thomas Heine +4 more
doaj +1 more source
When is a target not a target?
eLife, 2019 Cells rely on prolyl hydroxylase enzymes to sense low levels of oxygen, but they might act on fewer targets than previously thought.
David C Bersten, Daniel J Peet
doaj +1 more source
Experimental realization of catalytic CH_4 hydroxylation predicted for an iridium NNC pincer complex, demonstrating thermal, protic, and oxidant stability [PDF]
, 2009 A discrete, air, protic, and thermally stable (NNC)Ir(III) pincer complex was synthesized that catalytically activates the CH bond of methane in trifluoroacetic acid; functionalization using NaIO_4 and KIO_3 gives the oxy ...
Ess, Daniel H. +6 more
core +1 more source
The Remarkable Structural Diversity Achieved in ent-Kaurane Diterpenes by Fungal Biotransformations
Molecules, 2014 The use of biotransformations in organic chemistry is widespread, with highlights of interesting applications in the functionalization of natural products containing unactivated carbons, like the kaurane diterpenes.
Jacqueline A. Takahashi +4 more
doaj +1 more source
Stereochemistry of the α-oxidation of 3-methyl-branched fatty acids in rat liver
Journal of Lipid Research, 1999 The stereochemistry of the α-oxidation of 3-methyl-branched fatty acids was studied in rat liver. R- and S-3-methylhexadecanoic acid were equally well α-oxidized in intact hepatocytes and homogenates.
Kathleen Croes +4 more
doaj +1 more source
Angewandte Chemie International Edition, EarlyView.An asymmetric Fe–Te dual‐atom pair directs peroxymonosulfate activation toward long‐lived surface‐bound hydroxyl radicals through strong p–d hybridization. The resulting electronic asymmetry enables efficient pharmaceutical degradation and reveals a metal–metalloid pairing strategy for steering reactive oxygen species pathways in advanced oxidation ...
Xuheng Li +6 more
wiley +1 more source
Dynamics of Antimicrobial Peptide Encapsulation in Carbon Nanotubes: The Role of Hydroxylation
International Journal of Nanomedicine, 2022 Maryam Zarghami Dehaghani,1 Farrokh Yousefi,2 Farzad Seidi,1 S Mohammad Sajadi,3,4 Navid Rabiee,5 Sajjad Habibzadeh,6 Amin Esmaeili,7 Amin Hamed Mashhadzadeh,8 Christos Spitas,8 Ebrahim Mostafavi,9,10 Mohammad Reza Saeb11 1Jiangsu Co-Innovation Center of
Zarghami Dehaghani M +10 more
doaj
Green Chemistry Letters and Reviews, 2018 A novel, microwave-assisted method producing anilines and phenols from activated aryl halides is reported. This high-yielding method reduces current reaction requirements and removes organic solvents and catalysts making a more efficient and eco-friendly
N. McConnell, B. Frett, H. Li
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