Results 101 to 110 of about 95,661 (297)

Complete Pathway Refactoring and Combinatorial Biosynthesis of Anthracyclines for Modulation of Histone Eviction and DNA Damage Bioactivities

Angewandte Chemie, EarlyView.
A synthetic biology platform was established for the complete refactoring of complex anthracycline biosynthetic pathways in Streptomyces coelicolor using standardized, chemically synthetic DNA parts. This modular construction enabled streamlined combinatorial biosynthesis, yielding novel analogs that decouple DNA damage from chromatin damage (histone ...
Rongbin Wang, Heli Tirkkonen, Sabina Y. van der Zanden, Larissa Ponomareva, Isaline Fagon, Leslie Fève, Kendall Paige, Courtney L. Brown, Nora Schwartz, Jacob Hecht, Jennifer Nguyen, Jon S. Thorson, Jacques Neefjes, S. Eric Nybo, Khaled A. Shaaban, Mikko Metsä‐Ketelä   +15 more
wiley   +1 more source

Synthesis of Ethyl 2-Amino-6-hydroxy-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate and Ethyl 6-(Acetyloxy)-2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

Molbank
An effective one-step synthetic procedure for preparation of hydroxylated analogues of ethyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate as novel promising multifunctional building blocks for drug discovery based on the Gewald procedure was
Andrii Yu. Myshastyi, Sergiy V. Vlasov, Hanna I. Severina, Georgiy G. Yakovenko, Andrii R. Khairulin   +4 more
doaj   +1 more source

The Remarkable Structural Diversity Achieved in ent-Kaurane Diterpenes by Fungal Biotransformations

Molecules, 2014
The use of biotransformations in organic chemistry is widespread, with highlights of interesting applications in the functionalization of natural products containing unactivated carbons, like the kaurane diterpenes.
Jacqueline A. Takahashi, Dhionne C. Gomes, Fernanda H. Lyra, Gabriel F. dos Santos, Leonardo R. Martins   +4 more
doaj   +1 more source

The stereochemistry of fatty acid hydroxylation by cytochrome P450(BM3)

, 2007
The stereochemical preference for the cytochrome P450(BM3)-catalysed hydroxylation of tetradecanoic and pentadecanoic acids has been determined via comparison with authentic non-racemic standards utilising enantioselective HPLC.
Matovic, N., Matovic, Nick J., De Voss, James J., De Voss, J., Cryle, M., Cryle, Max J.   +5 more
core   +1 more source

Stereochemistry of the α-oxidation of 3-methyl-branched fatty acids in rat liver

Journal of Lipid Research, 1999
The stereochemistry of the α-oxidation of 3-methyl-branched fatty acids was studied in rat liver. R- and S-3-methylhexadecanoic acid were equally well α-oxidized in intact hepatocytes and homogenates.
Kathleen Croes, Minne Casteels, Martine Dieuaide-Noubhani, Guy P. Mannaerts, Paul P. Van Veldhoven   +4 more
doaj   +1 more source

Second‐Sphere Aromatic Substitutions That Tune H‐Atom Transfer Reactivity Observed for a Series of S = 1 Nonheme FeIV=O Complexes: An Enthalpy‐Entropy Compensation Effect

Angewandte Chemie, EarlyView.
A series of oxoiron(IV) complexes was synthesized to determine the impact of electronically tuned aromatic substitution in the secondary sphere of the ligand. Despite possessing identical electronic properties, they show significant differences in C─H oxidation reactions.
Abhishek Das, Jin Xiong, Victor G. Young Jr., Yisong Guo, Marcel Swart, Lawrence Que Jr.   +5 more
wiley   +1 more source

Dynamics of Antimicrobial Peptide Encapsulation in Carbon Nanotubes: The Role of Hydroxylation

International Journal of Nanomedicine, 2022
Maryam Zarghami Dehaghani,1 Farrokh Yousefi,2 Farzad Seidi,1 S Mohammad Sajadi,3,4 Navid Rabiee,5 Sajjad Habibzadeh,6 Amin Esmaeili,7 Amin Hamed Mashhadzadeh,8 Christos Spitas,8 Ebrahim Mostafavi,9,10 Mohammad Reza Saeb11 1Jiangsu Co-Innovation Center of
Zarghami Dehaghani M, Yousefi F, Seidi F, Sajadi SM, Rabiee N, Habibzadeh S, Esmaeili A, Mashhadzadeh AH, Spitas C, Mostafavi E, Saeb MR   +10 more
doaj  

Biocatalysis

, 2014
Hydroxylation reactions catalysed using P450 enzymes have a range of applications in drug metabolite production and lead diversification Facilitating the identification of toxic metabolites early in the drug development process and enabling the ...
Hydroxylation Reactions P Enzymes
core  

Microwave-assisted green synthesis of anilines, phenols, and benzenediamines without transition metals, ligands, or organic solvents

Green Chemistry Letters and Reviews, 2018
A novel, microwave-assisted method producing anilines and phenols from activated aryl halides is reported. This high-yielding method reduces current reaction requirements and removes organic solvents and catalysts making a more efficient and eco-friendly
N. McConnell, B. Frett, H. Li
doaj   +1 more source

Aliphatic Hydroxylation by a Bis(μ-oxo)dinickel(III) Complex

, 2016
Aliphatic Hydroxylation by a Bis(μ-oxo)dinickel(III ...
Shunichi Fukuzumi (1326822), Shinobu Itoh (1405678), Hideki Bandoh (2984637), Shigenori Nagatomo (780037), Teizo Kitagawa (780041)   +4 more
core   +1 more source