Results 121 to 130 of about 85,771 (308)

Total Syntheses of Agelamadin F and (±)‐Tauroacidin A, Enabled by NaClO2‐Mediated Coupling Reactions of Oroidin and Amines

Chemistry – A European Journal, EarlyView.
Total syntheses of agelamadin F and (±)‐tauroacidin A were achieved by sodium chlorite (NaClO2)‐mediated oxidative C─N coupling. Nine C15–N–amino acid‐substituted oroidin derivatives were successfully prepared to demonstrate the applicability and versatility of this oxidative coupling reaction.
Ryosuke Hirozumi, Yuta Kudo, Yuko Cho, Mari Yotsu‐Yamashita   +3 more
wiley   +1 more source

Elucidation of the β-carotene hydroxylation pathway in Arabidopsis thaliana

, 2006
The first dedicated step in plant xanthophyll biosynthesis is carotenoid hydroxylation. In Arabidopsis thaliana, this reaction is performed by both heme (LUT1 and LUT5) and non-heme (CHY1 and CHY2) hydroxylases.
Dall’Osto, Luca, Fiore, Alessia, Giuliano, Giovanni, Fraser, Paul D., Bassi, Roberto   +4 more
core   +1 more source

A Novel Workflow for Fast Elucidation of Drug Metabolites for Screening—Combining In Silico Metabolite Prediction With Trapped Ion Mobility QTOF‐MS

Drug Testing and Analysis, EarlyView.
UHPLC‐timsTOF‐MS with in silico prediction and automated annotation enabled rapid identification of quetiapine metabolites from pHLMs, facilitating their inclusion in targeted LC‐QTOF‐MS urine screening and improving biomarker detection for toxicological applications.
Annette Zschiesche, Birgit Schneider, Ilona Nordhorn, Carsten Baessmann, Laura M. Huppertz, Jürgen Kempf   +5 more
wiley   +1 more source

davidbajnai/hydroxylation: published-version

<p>This release contains the files used for the published version of the manuscript.</p ...
David Bajnai
core   +1 more source

Investigation of the In Vitro and In Vivo Metabolism and μ‐Opioid Receptor Affinity of the Nitazene N‐Pyrrolidino Fluetonitazene

Drug Testing and Analysis, EarlyView.
Eight metabolites for N‐pyrrolidino fluetonitazene were identified in vitro, three of which (M2, M6 and M8) were present in an authentic urine sample. M2 was the most abundant in vivo metabolite and is a common marker metabolite of nitazepyne‐type substances.
Severin Zemp, Gaia Alluisetti, Wolfgang Weinmann, Bettina Schrag, Frank Sporkert, Maurine Leclerc, Katharina Elisabeth Grafinger   +6 more
wiley   +1 more source

Simultaneous H2O:O2 Co‐Reactant Pulsing for Functional Property Control of Atomic Layer Deposited ZnO, TiO2, and Al2O3 Thin Films

Advanced Materials Interfaces
Fabrication of metal‑oxide thin films with precisely controlled crystallographic texture and defect chemistry is an increasingly important target in atomic layer deposition (ALD), in efforts to optimize the application performance of these thin films ...
Ramin Ghiyasi, Maarit Karppinen
doaj   +1 more source

Phase I Metabolism of Novel Phencyclidine Derivative 3‐Cl‐PCP: In Vitro Studies With Pooled Human Liver Microsomes and Investigation of a Post‐Mortem Case

Drug Testing and Analysis, EarlyView.
A fatal 3‐chloro‐phencyclidine (3‐Cl‐PCP) intoxication was investigated by analyzing postmortem samples and a pooled human liver microsomes assay. Tentative metabolite identification was performed by liquid chromatography‐quadrupole time‐of‐flight mass spectrometry (LC‐QTOF‐MS). Seven phase I metabolites were identified.
Johannes Kutzler, Tobias Veit, Thomas Keller, Volker Auwärter   +3 more
wiley   +1 more source

Cholesterol homeostasis in the brain : importance of 24S-hydroxylation

, 1999
Brain cholesterol is characterized by a very low turnover with very little exchange with lipoproteins in the circulation. We have investigated whether side chain-hydroxylated cholesterol species are important for elimination of cholesterol from the brain.
Dieter Lütjohann (186632)
core  

The stereochemistry of fatty acid hydroxylation by cytochrome P450(BM3)

, 2007
The stereochemical preference for the cytochrome P450(BM3)-catalysed hydroxylation of tetradecanoic and pentadecanoic acids has been determined via comparison with authentic non-racemic standards utilising enantioselective HPLC.
Matovic, Nicholas J., Matovic, N., Matovic, Nick J., De Voss, James J., De Voss, J., Cryle, M., Cryle, Max, Cryle, Max J.   +7 more
core   +1 more source

In Vitro Metabolism of Δ8‐, Δ9‐, and Δ10‐THC in Human Hepatocytes: Distinct Δ10‐THC Biotransformation and Implications for Drug Testing

Drug Testing and Analysis, EarlyView.
Δ8‐THC and Δ9‐THC showed comparable metabolic profiles. In contrast, Δ10‐THC underwent extensive glucuronidation and hydroxylation, with only minor formation of a carboxy metabolite, indicating a markedly different metabolic pathway. These differences may increase the risk of misidentification and misinterpretation in cannabis drug testing.
Robert Kronstrand, Henrik Green, Markus Loh, Fabian Rüttimann, Manuela Carla Monti   +4 more
wiley   +1 more source