Results 161 to 170 of about 143,720 (300)

Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.
Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen, Chaozhuang Shen, Yuchen Tian, Yuhe Peng, Jing Hu, Haitang Xie, Ping Yin   +6 more
wiley   +1 more source

Functional characterization of a novel <i>p</i>-coumarate 3-hydroxylase from <i>Trametes versicolor</i>. [PDF]

Appl Environ Microbiol
Hamajima L, Mori R, Tsurigami R, Yoshida Y, Kato H, Hayasaka M, Suzuki H, Kato M, Shimizu M.   +8 more
europepmc   +1 more source

Using MALDI‐FTICR Mass Spectrometry to Enhance ZooMS Identifications of Pleistocene Bone Fragments Showing Variable Collagen Preservation

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale Recent advances in high‐throughput molecular analyses of collagen peptides, especially ZooMS (Zooarchaeology by Mass Spectrometry), have permitted breakthroughs in the analysis of archaeological material that is highly fragmented, a factor that hinders morphological identification.
Pauline Raymond, Karen Ruebens, Fabrice Bray, Jean‐Christophe Castel, Eugène Morin, Foni Le Brun‐Ricalens, Jean‐Guillaume Bordes, Christian Rolando, Jean‐Jacques Hublin   +8 more
wiley   +1 more source

Functional characterization of steroid hydroxylation by cytochrome P450 enzymes from Rhodococcus erythropolis KB1. [PDF]

Microb Cell Fact
Ma J, Zhuang Y, Guan H, Zhang Z, Zhu N, Han C, Wang Y, Chen J.   +7 more
europepmc   +1 more source

Bile acid metabolism and sleep: Mechanistic interplay and clinical implications of the gut–liver–brain axis

Sleep Research, EarlyView.
Abstract The bidirectional interplay between sleep and metabolic homeostasis is fundamental to physiological health. While the roles of glucose and lipid metabolism in sleep regulation have been extensively characterized, bile acids (BAs), which are traditionally viewed as digestive surfactants, are emerging as critical metabolic messengers with ...
Yu Jiang, Shuangyan Li, Dhirendra Paudel, Miaoqin Tan, Bin Zhang   +4 more
wiley   +1 more source

Strategies for Optimizing the Yield and Function of Recombinant Collagen in Different Expression Systems: A Review. [PDF]

Int J Mol Sci
Cheng M, Jiang L, Zhang Z, Ji L, Xiong Z, Wang G, Ai L, Liu X.   +7 more
europepmc   +1 more source

Simplified Spray Pyrolysis Synthesis Enabling a Novel Dual‐Doping Strategy for Ultrahigh‐Rate Ni‐Rich Cathode Materials for Lithium‐Ion Batteries

Small, EarlyView.
A novel concept for simplified Zr‐ and Ti‐co doping in Ni‐rich layered cathode materials via spray pyrolysis was introduced, delivering excellent rate performance. Spray pyrolysis enables the synthesis of Li‐containing precursors and allows for short‐term, low‐temperature calcination.
Ha Kyeong Kim, Tae Ha Kim, Han‐Koo Lee, Hyungsub Kim, Won Gi Hong, Young‐Sang Yu, Gi Dae Park, Sang Mun Jeong   +7 more
wiley   +1 more source

Engineering a cytochrome P450 enzyme as a peroxygenase for selective hydroxylation of steroids. [PDF]

Nat Commun
Tang T, Wang R, Chen Y.
europepmc   +1 more source

Suppress Ru Over‐Oxidation Through Oxygen Vacancy Engineering – Showcase With Ni‐Modified RuO2 via Molten‐Salt Synthesis

Small, EarlyView.
Competitive OER catalyst for H2O splitting without using Ir is a luxury wish; Ru is an active element to do the job but often does not hold long. See how those scientists managed the task with Ni modified RuO2 suppressing Ru over‐oxidation through Oxygen Vacancy Engineering.
Ebrahim Sadeghi, Hee Jung Kwon, Celine Maynau, Martin Aaskov Karlsen, Per Morgen, Raghunandan Sharma, Minho Kim, Luc Lajaunie, Shuang Ma Andersen   +8 more
wiley   +1 more source

Dynamic observation of reductive and oxidative hydroxylation of CoO _<i>x</i> nanostructures in water vapor. [PDF]

Natl Sci Rev
Sun X, Wang D, Zhang R, Liang X, Lin L, Li R, Mu R, Fu Q.   +7 more
europepmc   +1 more source