Results 181 to 190 of about 95,661 (297)

The role of tryptophan hydroxylase‐1 in metabolic dysfunction‐associated steatotic liver disease

Pediatric Investigation, EarlyView.
Silencing hepatic tryptophan hydroxylase 1 (TPH1) alleviated diet‐induced steatotic liver disease by reducing lipid accumulation, oxidative stress, inflammation, fibrosis, and hepatocyte apoptosis. These protective effects were mediated, at least in part, through restoration of Parkin‐dependent mitochondrial autophagy, identifying hepatic TPH1 as a ...
Shuangzhen Jia, Xiaolin Ye, Zhaoxia Wang, Jie Wu   +3 more
wiley   +1 more source

Biotransformation of Coumarins: Mechanisms and Pharmaceutical Potential. [PDF]

Molecules
Saragih M, Szczepańska E, Olejniczak T.
europepmc   +1 more source

Towards greener yttrium‐catalyzed ring‐opening polymerization via an all‐terpene reaction concept

Polymer International, EarlyView.
Development of a terpene‐based catalytic system for ring‐opening polymerization of bio‐based lactones that reveals the steric effects of the nucleophile on initiation and alkoxide exchange, while simultaneously enabling post‐polymerization functionalization.
Lea‐Sophie Hornberger, Jonas App, Caroline Sophie Pottgiesser, Friederike Adams   +3 more
wiley   +1 more source

Active-site recognition enables hydroxylation of a fluorine-deactivated C-H bond in 6,6,6-trifluoro-L-norleucine.

Chem Commun (Camb)
Ismail M, Fakhry A, Hamaway W, Elkafoury EM, Nisar N, Swift T, Telford R, Hamed RB.   +7 more
europepmc   +1 more source

C₁-Symmetric Salan-Zr(IV) Catalyst for Efficient and Highly Enantioselective α-Hydroxylation of β-Keto Esters and Amides. [PDF]

Chem Asian J
Ma C, Tang K, Zhao J, Wu Y, Wang Y, Li J, Liu Q, Meng Q.   +7 more
europepmc   +1 more source

Leucaena Oil Functionalized With Osmium Tetroxide as a Precursor for Polyol‐Based Polyurethane

Journal of Polymer Science, EarlyView.
Leucaena leucocephala seed oil is converted into a hydroxyl‐functional biopolyol through OsO4‐mediated dihydroxylation. The resulting biopolyol shows a hydroxyl number of 160–175 mg KOH g−1 and is successfully used to produce flexible, open‐cell polyurethane foams, highlighting a renewable route for converting underutilized biomass into value‐added ...
Giovanni Miraveti Carriello, Lucas Repecka Alves, Guilherme Manassés Pegoraro, Henrique Solowej Medeiros Lopes, Amanda Stefanie Jabur de Assis, Thaís de Agrella Janolla, David Rodrigues Gomes, Diego Aleixo da Silva, Beatriz Merillas, Fabiana Aparecida Lobo, Fabio Minoru Yamaji, Maira de Lourdes Rezende, Aparecido Junior de Menezes, Giovanni Pimenta Mambrini   +13 more
wiley   +1 more source

Structural basis for oxidative decarboxylation of lignin-derived aromatics by the fungal flavoprotein monooxygenase PcMNX1. [PDF]

J Biol Chem
Mori R, Suzuki H, Ishida T, Sakai K, Yamaguchi S, Sunagawa N, Igarashi K, Kato M, Shimizu M.   +8 more
europepmc   +1 more source

From knowledge to action: the importance of characterizing herbicide resistance mechanisms for implementing management strategies

Pest Management Science, EarlyView.
This review bridges the gap between understanding resistance mechanisms and applying them in weed management, highlighting how mechanistic insights reveal vulnerabilities that can guide more effective control strategies. Abstract Herbicide resistance remains one of the most intensively studied areas in weed science because of its direct consequences ...
Luan Cutti, Eric L. Patterson, Todd A. Gaines, Aldo Merotto   +3 more
wiley   +1 more source

PHD1-dependent hydroxylation of RepoMan (CDCA2) on P604 modulates the control of mitotic progression. [PDF]

Elife
Druker J, Jiang H, Shakir D, Child F, Alvarez V, Platani M, Corno A, Alabert C, Saurin AT, Swedlow JR, Rocha S, Lamond AI.   +11 more
europepmc   +1 more source

Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.
Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen, Chaozhuang Shen, Yuchen Tian, Yuhe Peng, Jing Hu, Haitang Xie, Ping Yin   +6 more
wiley   +1 more source