Results 281 to 290 of about 194,006 (386)

Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation

Oncogene, 2013
Hui Yang, Yang Liu, Fenghua Bai, Jin Ye Zhang, Shenghong Ma, Juan Liu, Xu Zd, Hai-Rong Zhu, Ling Zq, Dan Ye, Kun-Liang Guan, Kun-Liang Guan, Yue Xiong, Yue Xiong   +13 more
semanticscholar   +1 more source

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Tale of two transcription factors: NF-кB and HIF crosstalk [PDF]

, 2013
Bandarra, D., Rocha, S.
core   +1 more source

Influence of EDTA Coverage Density on Optical Fiber Sensor for Heavy Metal Ion Detection

Nano Select, EarlyView.
This study investigates the influence of chelating agent coverage on the performance of optical fiber sensors for heavy metal ion detection. Ethylenediaminetetraacetic acid (EDTA) was employed to functionalize single‐mode 28 optical fibers (SMF‐28), and the influence of surface coverage uniformity on zinc ion sensing performance was investigated ...
Zhejun Xu, Arun Jaiswal, Xiaochen Liu, Zhenxu Yang, Qiankun Yin, Ken‐Tye Yong   +5 more
wiley   +1 more source

Development of an HPLC-HRMS Method for the Identification and Semi-Quantitation in River Water Samples of the Transformation Products Originated From Heterogeneous Photocatalysis of Antipsychotic Drugs. [PDF]

J Sep Sci
De Rosa E, Arpaia S, Michelina SV, Oliva F, Medana C, Calza P, Dal Bello F.   +6 more
europepmc   +1 more source

Modifying Antibiotic Activity of Synthetic Thiadiazine Analogs Against MDR Bacteria and ADMET Analysis

ChemistryOpen, EarlyView.
The study demonstrated that thidiazine compounds potentiated the action of antibiotics. The compounds associated with norfloxacin against S. aureus showed greater significance in relation to the other medications. The indiscriminate use of antibiotics has led to the selection of resistant bacterial strains, significantly reducing the effectiveness of ...
João Arthur de Oliveira Borges, Priscilla Ramos Freitas, Isaac Moura Araújo, Ray Silva de Almeida, Igor José dos Santos Nascimento, João Xavier de Araújo‐Júnior, Edeildo Ferreira da Silva‐Júnior, Thiago Mendonça de Aquino, Francisco Jaime Bezerra Mendonça Junior, Emmanuel Silva Marinho, Hélcio Silva dos Santos, Radosław Kowalski, Grażyna Kowalska, Henrique Douglas Melo Coutinho, Saulo Relison Tintino, Ana Carolina Justino de Araújo   +15 more
wiley   +1 more source

Corrigendum to “Highly selective conversion of H2O2 to 1O2 via three-step electron transfer enabled by in-situ hydroxylation of atomically dispersed high-density Co–N5 sites” [Appl. Catal. B: Environ. Energy 365 (2025) 124951]

Bolong Zhao, Yulong Ma, Yonggang Sun, Guangsuo Yu, Juan Zhang, Li Zhu, Min Xu, Lei Wang, Dongxu Zhao, Wenxin Ji, Yuanyuan Li, Yongsheng Ren   +11 more
openalex   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Membrane changes during syntrophic interactions of an archaeal-bacterial coculture. [PDF]

BMC Microbiol
Fiege K, Asbun AA, Boeren S, Engelmann JC, Villanueva L.   +4 more
europepmc   +1 more source

Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.
Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen, Chaozhuang Shen, Yuchen Tian, Yuhe Peng, Jing Hu, Haitang Xie, Ping Yin   +6 more
wiley   +1 more source