Results 281 to 290 of about 111,305 (353)
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Remote Hydroxylation through Radical Translocation and Polar Crossover
Angewandte Chemie - International Edition, 2015Mild conditions are reported for the hydroxylation of aliphatic C-H bonds through radical translocation, oxidation to carbocation, and nucleophilic trapping with H2O.
A Massironi, Justin R Ragains
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One‐Step Selective Hydroxylation of Benzene to Phenol
Asian Journal of Organic Chemistry, 2015Recent developments in the one-step thermal and photochemical catalytic hydroxylation of benzene to phenol using various oxidants are described, focusing on the catalytic mechanisms.
Kei Ohkubo
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Iron-catalyzed arene C−H hydroxylation
Science, 2021Description Ironing on hydroxyls Although iron-dependent enzymes efficiently hydroxylate aryl rings, this activity has proven hard to replicate with synthetic catalysts. Cheng et al.
Lu Cheng +5 more
semanticscholar +1 more source
Canadian Journal of Biochemistry and Physiology, 1963
The mixture of products obtained when skatole is oxidized with the ferrous sulphate – ascorbic acid – EDTA – air system has been examined by means of paper and thin layer chromatographic techniques. 3-Methyloxindole, o-aminoacetophenone, N-formyl-o-aminoacetophenone, and the four isomeric hydroxyskatoles have been definitely identified. A number of, as
M. E. Mahon, R. A. Heacock
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The mixture of products obtained when skatole is oxidized with the ferrous sulphate – ascorbic acid – EDTA – air system has been examined by means of paper and thin layer chromatographic techniques. 3-Methyloxindole, o-aminoacetophenone, N-formyl-o-aminoacetophenone, and the four isomeric hydroxyskatoles have been definitely identified. A number of, as
M. E. Mahon, R. A. Heacock
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The hydroxylation of tryptophan
Archives of Biochemistry and Biophysics, 1992Products of the chemical hydroxylation of tryptophan by Fenton and Udenfriend reactions are similar to those obtained by ionizing radiation. When tryptophan is exposed to either of these systems, a mixture of four hydroxytryptophans, oxindole-3-alanine, and N-formylkynurenine is formed.
Zofia Maskos +2 more
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Hydroxylation of desmethylimipramine: Dependence on the debrisoquin hydroxylation phenotype
Clinical Pharmacology and Therapeutics, 1987The 2-hydroxylation of desmethylimipramine (DMI) was studied in 14 healthy subjects previously phenotyped with respect to debrisoquin hydroxylation. After a single oral dose (25 mg), slow hydroxylators of debrisoquin had significantly lower total and metabolic clearances and longer plasma half-lives of DMI and excreted less 2-hydroxydesmethylimipramine
SPINA, Edoardo +3 more
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Stereoselective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylation
Clinical Pharmacology and Therapeutics, 1985The 8-hour urinary recovery of 4-hydroxy-mephobarbital has been measured after oral administration of racemic mephobarbital (90 mg) in 17 extensive (EM) and six poor (PM) metabolizer phenotypes of mephenytoin. The recovery of this metabolite was measurable in every EM and ranged from 2.5% to 48% (10.9% +/- 1.9% of dose), but was not detected in any PM (
A Küpfer +3 more
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Hydroxylation of 3-nitrotyrosine by hydroxyl radical
Chinese Chemical Letters, 2007Abstract Hydroxylation of 3-nitrotyrosine (3-NT) and 3-NT containing peptide Gly-nitroTyr-Gly in aqueous solution by hydroxyl radical were investigated with gamma irradiation. The structures of the hydroxylated products were confirmed by electrospray ionization mass spectrometry and 1 H NMR spectrometry.
Yufen Zhao +3 more
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Analytical Biochemistry, 1981
Abstract A mixture of xanthine or hypoxanthine and xanthine oxidase generates the superoxide radical, O2 • , and H2O2. In the presence of iron salts, O2 • and H2O2 can interact to produce the hydroxyl radical, OH·. Superoxide-dependent formation of OH· can be measured by its ability to hydroxylate salicylate as followed by an improved ...
Jasbir Chauhan +3 more
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Abstract A mixture of xanthine or hypoxanthine and xanthine oxidase generates the superoxide radical, O2 • , and H2O2. In the presence of iron salts, O2 • and H2O2 can interact to produce the hydroxyl radical, OH·. Superoxide-dependent formation of OH· can be measured by its ability to hydroxylate salicylate as followed by an improved ...
Jasbir Chauhan +3 more
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[6] Detection of hydroxyl radicals by aromatic hydroxylation
1994Publisher Summary The hydroxyl radical •OH is the most reactive species. The hydroxyl radical reacts at, or close to, a diffusion-controlled rate with all biological molecules, and its half-life in cells is estimated to be 10 -9 sec. It is produced when water is exposed to ionizing radiation, fragmenting the oxygen-hydrogen covalent bond, leaving a ...
Barry Halliwell, Harparkash Kaur
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