Results 21 to 30 of about 111,305 (353)
Computational Insight Into Vitamin K1 ω-Hydroxylation by Cytochrome P450 4F2
Frontiers in Pharmacology, 2018 Vitamin K1 (VK1) plays an important role in the modulation of bleeding disorders. It has been reported that ω-hydroxylation on the VK1 aliphatic chain is catalyzed by cytochrome P450 4F2 (CYP4F2), an enzyme responsible for the metabolism of eicosanoids ...
Junhao Li +6 more
doaj +1 more source
Molecules, 2014 During the last several decades TiO2 photocatalytic oxidation using the molecular oxygen in air has emerged as a promising method for the degradation of recalcitrant organic pollutants and selective transformations of valuable organic chemicals.
Xibin Pang +5 more
doaj +1 more source
Fluorescent Bis(guanidine) Copper Complexes as Precursors for Hydroxylation Catalysis
Inorganics, 2018 Bis(guanidine) copper complexes are known for their ability to activate dioxygen. Unfortunately, until now, no bis(guanidine) copper-dioxygen adduct has been able to transfer oxygen to substrates.
Florian Strassl +8 more
doaj +1 more source
Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?
Cells, 2019 All metazoans that utilize molecular oxygen (O2) for metabolic purposes have the capacity to adapt to hypoxia, the condition that arises when O2 demand exceeds supply. This is mediated through activation of the hypoxia-inducible factor (HIF) pathway.
Moritz J. Strowitzki +2 more
semanticscholar +1 more source
Molecules, 2019 9α-Hydroxy-4-androstene-3,17-dione (9-OH-AD) is one of the significant intermediates for the preparation of β-methasone, dexamethasone, and other steroids. In general, the key enzyme that enables the biotransformation of 4-androstene-3,17-dione
Xian Zhang +10 more
doaj +1 more source
Modulation of TRP Channel Activity by Hydroxylation and Its Therapeutic Potential
Pharmaceuticals, 2017 Two transient receptor potential (TRP) channels—TRPA1 and TRPV3—are post-translationally hydroxylated, resulting in oxygen-dependent regulation of channel activity.
Yagnesh Nagarajan +2 more
doaj +1 more source
Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
eLife, 2019 Human and other animal cells deploy three closely related dioxygenases (PHD 1, 2 and 3) to signal oxygen levels by catalysing oxygen regulated prolyl hydroxylation of the transcription factor HIF. The discovery of the HIF prolyl-hydroxylase (PHD) enzymes
Matthew E Cockman +10 more
doaj +1 more source
Role of prolyl hydroxylation in the molecular interactions of collagens
Essays in Biochemistry, 2019 Co- and post-translational hydroxylation of proline residues is critical for the stability of the triple helical collagen structure. In this review, we summarise the biology of collagen prolyl 4-hydroxylases and collagen prolyl 3-hydroxylases, the ...
P. Rappu +3 more
semanticscholar +1 more source
Frontiers in Plant Science, 2022 Scots pine heartwood is known to have resistance to wood decay due to the presence of extractives, namely stilbenes and resin acids. However, previous studies have indicated that these extractives are degradable by wood decaying fungi.
Tiina Belt +3 more
doaj +1 more source
Molecules, 2023 In humans, tetrahydrobiopterin (H4Bip) is the cofactor of several essential hydroxylation reactions which dysfunction cause very serious diseases at any age.
Ayoub Boulghobra +7 more
doaj +1 more source