Results 301 to 310 of about 111,305 (353)
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Estrogen Hydroxylation in Osteoporosis
2007Estrogen is metabolized predominantly via two competing pathways, the 2-hydroxyl (nonestrogenic) and the 16alpha-hydroxyl (estrogenic) pathways. Studies have indicated that these pathways are important determinants of bone mineral density (BMD) in postmenopausal women.
Reina Armamento-Villareal, Nicola Napoli
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Hydroxylation of Alkylbenzenes
Journal of the Fuel Society of Japan, 1956ベンゼンをプロピレン・ブチレンでアルキル化して得られるキューメン, p-ジイソプロピルペンゼ, 第2級ブチルベンゼン, p-ジ-第2級ブチルベンゼンのハイドロキシル化をナフテン酸コバルト触媒を用い, 80℃ 附近の低温度で加圧酸化すると, キューメン, P-ジイソプロピルベンゼンのようにイソプロピルをもつているものは容易にハイドロキシル化され, それに相当するアルコールを生成するが, 第2級ブチル基を有する第2級ブチルベンゼン, p-ジー第2級ブチルベンゼンはアルコールよりもケトンを生成し易い。このアルコールの生成はハイドロパーオキサイドを中間体として進むものと思われ, キューメン, p-ジイソプロピルベンゼンのハイドロパーオキサイドは容易にそれに相当するアルコールに変化した。
Takaaki Arakawa +3 more
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The microbiological hydroxylation of levonorgestrel
Natural Product Research, 2006The microbial transformation of levonorgestrel (1) by Cunningham elegans resulted in the formation of five hydroxylated metabolites, 13-ethyl-10beta, 17beta-dihydroxy-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one(2), 13-ethyl-6beta,17beta-dihydroxy-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one (3) 13-ethyl 6beta, 10beta, 17beta-trihydroxy-18,19-dinor-17alpha-
Atta-ur-Rahman +4 more
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Hydroxylated Kininogens and Kinins
1992Hydroxyprolyl-3-bradykinin was identified in the digest of purified human high molecular weight (H) kininogen with plasma kallikrein. Hydroxyproline was not detected in the heavy and light chains portions of H kininogen, although they include three possible sites for hydroxylation of proline by proline hydroxylase.
Enjyoji K, Kato H
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, 2016
We performed reactive force field molecular dynamics simulation to observe the hydrolysis reactions between water molecules and locally strained SiO2 geometry. We optimized the force field from J. Fogarty et al.
Jejoon Yeon, A. Duin
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We performed reactive force field molecular dynamics simulation to observe the hydrolysis reactions between water molecules and locally strained SiO2 geometry. We optimized the force field from J. Fogarty et al.
Jejoon Yeon, A. Duin
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Cold Spring Harbor Protocols, 2007
INTRODUCTIONThe hydroxyl-radical footprinting methodology has wide applications to studying protein-DNA interactions, as well as structural perturbations (e.g., bending) that occur in DNA during protein binding. Hydroxyl radicals cleave DNA by abstracting a hydrogen atom from C4 of the sugar in the minor groove.
Stephen T. Smale, Michael Carey
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INTRODUCTIONThe hydroxyl-radical footprinting methodology has wide applications to studying protein-DNA interactions, as well as structural perturbations (e.g., bending) that occur in DNA during protein binding. Hydroxyl radicals cleave DNA by abstracting a hydrogen atom from C4 of the sugar in the minor groove.
Stephen T. Smale, Michael Carey
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Journal of the American Chemical Society, 2015
Selective hydroxylation of benzene to phenol has been achieved using H2O2 in the presence of a catalytic amount of the nickel complex [Ni(II)(tepa)](2+) (2) (tepa = tris[2-(pyridin-2-yl)ethyl]amine) at 60 °C.
Y. Morimoto +4 more
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Selective hydroxylation of benzene to phenol has been achieved using H2O2 in the presence of a catalytic amount of the nickel complex [Ni(II)(tepa)](2+) (2) (tepa = tris[2-(pyridin-2-yl)ethyl]amine) at 60 °C.
Y. Morimoto +4 more
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Journal of the American Chemical Society, 2015
An N-heterocyclic carbene-catalyzed β-hydroxylation of enals is developed. The reaction goes through a pathway involving multiple radical intermediates, as supported by experimental observations.
Yuexia Zhang +9 more
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An N-heterocyclic carbene-catalyzed β-hydroxylation of enals is developed. The reaction goes through a pathway involving multiple radical intermediates, as supported by experimental observations.
Yuexia Zhang +9 more
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Chemistry, 2015
Cytochrome P450 enzymes are highly versatile biological catalysts in our body that react with a broad range of substrates. Key functions in the liver include the metabolism of drugs and xenobiotics.
Li Ji +9 more
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Cytochrome P450 enzymes are highly versatile biological catalysts in our body that react with a broad range of substrates. Key functions in the liver include the metabolism of drugs and xenobiotics.
Li Ji +9 more
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Hydroxylation of Proline in Vitro
Nature, 1959WHILE carrying out a study of hydroxyproline synthesis in biological media, by hydroxylation of proline or peptides containing proline, we have also investigated the possibility of hydroxylation of pyrrolidine ring in vitro. We commenced our study by ascertaining1,2,3 whether or not cortisone inhibited the formation of free hydroxyproline in animal ...
J Hurych, M Chvapil
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