Results 41 to 50 of about 194,006 (386)

Biocatalytic hydroxylation of n-butane with in situ cofactor regeneration at low temperature and under normal pressure

Beilstein Journal of Organic Chemistry, 2012
The hydroxylation of n-alkanes, which proceeds in the presence of a P450-monooxygenase advantageously at temperatures significantly below room temperature, is described.
Svenja Staudt, Christina A. Müller, Jan Marienhagen, Christian Böing, Stefan Buchholz, Ulrich Schwaneberg, Harald Gröger   +6 more
doaj   +1 more source

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

Nature, 2010
TET2 is a close relative of TET1, an enzyme that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. The gene encoding TET2 resides at chromosome 4q24, in a region showing recurrent microdeletions and copy-neutral loss of ...
M. Ko, M. Ko, Yun Huang, Yun Huang, A. Jankowska, U. J. Pape, U. J. Pape, Mamta Tahiliani, Hozefa S. Bandukwala, Jungeun An, Jungeun An, E. Lamperti, Kian Peng Koh, Rebecca D. Ganetzky, X. Liu, L. Aravind, Suneet Agarwal, J. Maciejewski, Anjana Rao, Anjana Rao   +19 more
semanticscholar   +1 more source

Dechlorination-Hydroxylation of Atrazine to Hydroxyatrazine with Thiosulfate: A Detoxification Strategy in Seconds.

Environmental Science and Technology, 2019
Hydroxylation of atrazine to nontoxic hydroxyatrazine is generally considered an efficient detoxification method to remediate atrazine-contaminated soil and water.
Yi Mu, Guangming Zhan, Cuimei Huang, Xiaobing Wang, Zhihui Ai, J. Zou, S. Luo, Lizhi Zhang   +7 more
semanticscholar   +1 more source

Gas-Phase Lubrication of ta-C by Glycerol and Hydrogen Peroxide. Experimental and Computer Modeling [PDF]

, 2010
Tetrahedrally coordinated hydrogen-free amorphous diamond-like carbon coating (denoted as ta-C) presents ultralow friction under boundary lubrication conditions at 80 °C in presence of OH-containing molecules.
De Barros Bouchet, Maria-Isabel, Goddard, William A., III, Martin, Jean-Michel, Matta, Christine, Okuda, Sachiko, Sagawa, Takumaru, Zhang, Qing   +6 more
core   +1 more source

Recent Advances and Challenges in the Production of Hydroxylated Natural Products Using Microorganisms

Fermentation
Hydroxylation reaction is a significant source of structural diversity in natural products (NPs), playing a crucial role in improving the bioactivity, solubility, and stability of natural product molecules.
Chang Sun, Rumei Zeng, Tianpeng Chen, Yibing Yang, Yi Song, Qiang Li, Jie Cheng, Bingliang Liu   +7 more
doaj   +1 more source

The genome sequence of Barbarea vulgaris facilitates the study of ecological biochemistry [PDF]

, 2017
peer-reviewedThe genus Barbarea has emerged as a model for evolution and ecology of plant defense compounds, due to its unusual glucosinolate profile and production of saponins, unique to the Brassicaceae. One species, B.
Agerbirk, Niels, Asp, Torben, Bak, Søren, Byrne, Stephen, Hauser, Thure Pavlo, Nagy, Istvan, Paina, Cristiana, Østerbye Erthmann, Pernille   +7 more
core   +2 more sources

Regio- and stereoselective oxidation of unactivated C–H bonds with Rhodococcus rhodochrous

Beilstein Journal of Organic Chemistry, 2012
The ability of Rhodococcus rhodochrous (NCIMB 9703) to catalyse the regio- and stereoselective hydroxylation of a range of benzyloxy-substituted heterocycles has been investigated.
Elaine O’Reilly, Suzanne J. Aitken, Gideon Grogan, Paul P. Kelly, Nicholas J. Turner, Sabine L. Flitsch   +5 more
doaj   +1 more source

Studies on Regioselective Binding Mode of Steroid Molecules in Homology Modeled Cytochrome P450-2C11 [PDF]

, 2009
In this study, we investigated the regioselective binding mode of steroid molecules and structure requirements for steroid molecules for 16[alpha]-hydroxylation by Cytochrome P450-2C11.
Eiichi Akaho, Hamed I. Ali, Hukihisa Fujita, Morio Yamada   +3 more
core   +1 more source

Products of Vitamin D3 or 7-Dehydrocholesterol Metabolism by Cytochrome P450scc Show Anti-Leukemia Effects, Having Low or Absent Calcemic Activity [PDF]

, 2010
BACKGROUND. Cytochrome P450scc metabolizes vitamin D3 to 20-hydroxyvitamin D3 (20(OH)D3) and 20,23(OH)2D3, as well as 1-hydroxyvitamin D3 to 1a,20-dihydroxyvitamin D3 (1,20(OH)2D3).
Chen, Tai C., Fuller, Brian E., Holick, Michael F., Janjetovic, Zorica, Li, Wei, Lozanski, Gerard, Miller, Duane, Nguyen, Minh N., Slominski, Andrzej T., Sweatman, Trevor, Tuckey, Robert C., Zjawiony, Jordan, Zmijewski, Michal A.   +12 more
core   +5 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source