Results 81 to 90 of about 111,305 (353)

Engineering Electron Transfer Flux between Cytochrome P450 Enzyme and P450 Reductase to Enhance Serotonin Production in Escherichia Coli

Advanced Science, EarlyView.
The electron transfer flux in CPR‐P450 catalytic system is systematically engineered through: i) enhancing electron transfer rate by redesigning the putative electron transfer pathway of CPR; ii) improving electron‐receiving rate by evolving the heme domain of tryptophan‐5‐hydroxylase (T5H); iii) enlarging electron supply by fine‐tuning NADPH synthesis.
Wenzhao Xu, Pengling Wei, Lirong Chen, Ling Gao, Xiaole Xia   +4 more
wiley   +1 more source

Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia‐Inducible Factor‐1 Signaling Pathway

Advanced Science, EarlyView.
This study investigates the role of macrophage pyruvate carboxylase (PC) in atherosclerosis (AS) demonstrating that PC upregulation in macrophages promotes metabolism reprogramming to enhance inflammatory responses via the HIF‐1 signaling pathway.
Ling‐Na Zhao, Rui‐Ling Wang, Ran‐Xin Liu, Meng‐Ru Zheng, Li Zhao, Bao‐Feng Li, Jia‐Le Li, De‐Shen Liu, Xiao‐Xia He, Qin‐Bao Peng, Kai Li, Tian‐Xiao Lin, Ying‐Ying Liu, Sheng‐Ping He, Jun Lu, Shao‐Yi Zheng, Xiu Liu, Fang‐Ze Huang   +17 more
wiley   +1 more source

Detoxification of Ustiloxin A by Hydroxylation of Endophytic Fungus Petriella setifera Nitaf10

Microbiology Research
Ustiloxins are a kind of cyclopeptide mycotoxins produced by rice false smut pathogen Villosiclava virens, which seriously threatens the safe production of rice and health of humans and animals. Hydroxylation, a biotransformation reaction that regio- and
Peng Li, Xuwen Hou, Gan Gu, Daowan Lai, Ligang Zhou   +4 more
doaj   +1 more source

Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases*

Journal of Biological Chemistry, 2015
The post-translational hydroxylation of prolyl and lysyl residues, as catalyzed by 2-oxoglutarate (2OG)-dependent oxygenases, was first identified in collagen biosynthesis.
Suzana Markolovic, Sarah E Wilkins, C. Schofield   +2 more
semanticscholar   +1 more source

Comparative Analysis of Clinical Outcomes and Financial Aspects of Phototherapies and Immunotherapy for Cancer

Advanced Science, EarlyView.
This review compares clinical outcomes, translational progress, and global funding trends across cancer phototherapies—photodynamic, photothermal, and photoimmunotherapy—and conventional immunotherapy. It highlights differences in treatment efficacy, clinical trial status, financial investment, and regulatory challenges, providing a comprehensive ...
Deepak S. Chauhan, Kun Shao, Roopa Hebbandi Nanjundappa, Daniel‐Jiajun Yu, Marianne Stanford, Huile Gao, Channakeshava Sokke Umeshappa   +6 more
wiley   +1 more source

In Situ Observation of Post‐CO Intermediates to Decode C─C Coupling Pathways in CO2 Electroreduction

Angewandte Chemie, EarlyView.
Resonance Raman spectroscopy (RRS) was used to observe the in situ CO2 electroreduction process by designing copper electrodes with unique structures. This dynamic observation allowed for the capture of the C─C coupling process, where CH2 asymmetrically couples with CO to form CH2CO.
Mingxu Sun, David S. Rivera Rocabado, Jiamin Cheng, Tomohiro G. Noguchi, Masaki Donoshita, Takahiro Matsuu, Manabu Higashi, Tsuyohiko Fujigaya, Takayoshi Ishimoto, Miho Yamauchi   +9 more
wiley   +2 more sources

Energy‐Efficient Fabrication of Biomimetic Materials for Sustainable Infrastructure Applications

Advanced Science, EarlyView.
Inspired by nacre's “brick‐and‐mortar” structure, this work develops an energy‐efficient approach that utilizes ice‐templating technology as the structure framework and carbon mineralization for rapid CaCO3 production, resulting in a strong yet tough carbon mineralized material (CMM) under mild conditions while also fixing CO2.
Jingze Chen, Zhichao Liu, Shujun Zhang, Shuguang Hu, Fazhou Wang   +4 more
wiley   +1 more source

Origin of Room Temperature Methanol Synthesis over Hcp‐PdMo

Angewandte Chemie, EarlyView.
The hexagonal close‐packed PdMo (hcp‐PdMo) intermetallic catalyst exhibits the room temperature catalytic activity for CO2 hydrogenation to methanol, where the adjacently arranged Pd and Mo sites play important roles in methanol synthesis. Mechanism study revealed that the reaction proceeds via a reverse water‐gas shift and subsequent CO hydrogenation (
Feilong Xing, Ruopeng Wang, Shiyao Wang, Hironobu Sugiyama, Chenyang Zhu, Masayoshi Miyazaki, Hideo Hosono, Masaaki Kitano   +7 more
wiley   +2 more sources

Ultrasound‐Responsive Piezoelectric Membrane Promotes Osteoporotic Bone Regeneration via the “Two‐Way Regulation” Bone Homeostasis Strategy

Advanced Science, EarlyView.
Patients with osteoporosis face a higher risk of bone injury, mainly due to weakened osteogenic differentiation and bone formation, along with increased osteoclast differentiation and bone resorption activity, leading to bone homeostasis imbalance.
Xinhui Wu, Tianlong Wang, Jinhui Zhao, Lei Zhang, Zhiqing Liu, Yixing Chen, Yiping Luo, Yaqi Liu, Yan Chen, Hui Jiang, Dilixiati Duolikun, Junjian Liu, Wentao Cao, Longpo Zheng   +13 more
wiley   +1 more source

Dynamic Active Site Evolution in Lanthanum‐Based Catalysts Dictates Ethane Chlorination Pathways

Angewandte Chemie, EarlyView.
LaOCl‐catalyzed C2H6 chlorination offers a low‐carbon route for polyvinyl chloride synthesis, yet structural evolution occurs under Cl2 conditions. We establish structural sensitivity in La‐catalyzed chlorination, and elucidate the size‐dependent chlorophilicity of LaCl3 and the role of hydroxyl groups in overchlorination, highlighting stabilization of
Yuting Li, Haifeng Qi, Zihan Zhu, Xia Wu, Nicholas F. Dummer, Stuart H. Taylor, Lei Ma, Xiaofeng Yang, Qinggang Liu, Graham J. Hutchings, Yanqiang Huang   +10 more
wiley   +2 more sources