Investigation of putative active-site lysine residues in hydroxymethylbilane synthase. Preparation and characterization of mutants in which (a) Lys-55, (b) Lys-59 and (c) both Lys-55 and Lys-59 have been replaced by glutamine [PDF]
, 1990 Alfons Hädener +4 more
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Growth stimulation of biological cells and tissue by electromagnetic fields and uses thereof [PDF]
, 2004 The present invention provides systems for growing two or three dimensional mammalian cells within a culture medium facilitated by an electromagnetic field, and preferably, a time varying electromagnetic field.
Goodwin, Thomas J., Wolf, David A.
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Two deletion mutations in the hydroxymethylbilane synthase gene in two unrelated Japanese patients with acute intermittent porphyria [PDF]
, 2000 Noriaki Maeda +7 more
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FiTMuSiC: leveraging structural and (co)evolutionary data for protein fitness prediction
Human GenomicsSystematically predicting the effects of mutations on protein fitness is essential for the understanding of genetic diseases. Indeed, predictions complement experimental efforts in analyzing how variants lead to dysfunctional proteins that in turn can ...
Matsvei Tsishyn +5 more
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European mtDNA Variants Are Associated With Differential Responses to Cisplatin, an Anticancer Drug: Implications for Drug Resistance and Side Effects. [PDF]
, 2019 Background: Cisplatin, a powerful antitumor agent, causes formation of DNA adducts, and activation of apoptotic pathways. Presently, cisplatin resistance develops in up to 70% of patients but the underlying molecular mechanism(s) are unclear and there ...
Abedi, Sina +13 more
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Journal of Rare DiseasesBackground Acute intermittent porphyria (AIP) is a rare metabolic disorder caused by deficiency of hydroxymethylbilane synthase (HMBS), leading to accumulation of neurotoxic heme precursors. Its protean neurovisceral manifestations and the possibility of
Bhupender Arya +4 more
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Characterisation, genomic organisation, expression and function of the mEphA1 receptor Tyrosine Kinase [PDF]
, 2007 The Eph receptor tyrosine kinases and their ephrin ligands are cell surface molecules with a wide range of biological functions. Specifically, the Eph/ephrin receptor-ligand family influences cell behaviour during both embryogenesis and adult life ...
Coulthard, Mark G.
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