Results 141 to 150 of about 295,934 (166)
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13C-N.M.R. Studies on the pyrromethane cofactor of hydroxymethylbilane synthase
Tetrahedron Letters, 1988By growing Escherichiacoli in the presence of 5-amino [5-13C] laevulinic acid, the enzyme hydroxymethylbilane synthase is produced carrying 13C-labels in its pyrromethane cofactor. It is then proved by 13C-n.m.r. spectroscopy that the cofactor is bound to the protein via the sulphur atom of a cysteine residue.
Uwe Beifuss +3 more
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19-Bromo-1-hydroxymethylbilane a novel inhibitor of Uro'gen III synthase
Bioorganic & Medicinal Chemistry, 1994A novel hydroxymethylbilane analog, 19-Br-HMB (11), has been synthesized. Its activity with the enzyme Uro'gen III synthase shows competitive inhibition.
C, Pichon +4 more
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Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1988
Etude d'une famille chinoise avec analyse de l'activite enzymatique de l'uroporphyrinogen I synthase erythrocytaire et du porphobilinogen ...
F Y, Lee +5 more
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Etude d'une famille chinoise avec analyse de l'activite enzymatique de l'uroporphyrinogen I synthase erythrocytaire et du porphobilinogen ...
F Y, Lee +5 more
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Clinical Biochemistry, 1999
Acute intermittent porphyria (AIP) is an autosomal dominant inherited disease caused by a decreased activity of hydroxymethylbilane synthase (HMBS). As far as the gene abnormalities of the HMBS, many different mutations have been reported. In this work, we investigated the presence of mutations in a Japanese family with AIP.A 44-year-old Japanese male ...
N, Maeda +8 more
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Acute intermittent porphyria (AIP) is an autosomal dominant inherited disease caused by a decreased activity of hydroxymethylbilane synthase (HMBS). As far as the gene abnormalities of the HMBS, many different mutations have been reported. In this work, we investigated the presence of mutations in a Japanese family with AIP.A 44-year-old Japanese male ...
N, Maeda +8 more
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Comparative inhibition of hepatic hydroxymethylbilane synthase by both hard and soft metal cations
Canadian Journal of Biochemistry and Cell Biology, 1984The in vitro inhibition of hydroxymethylbilane synthase (EC 4.3.1.8, uroporphyrinogen I synthetase) obtained from livers of Sprague–Dawley rats has been studied with a wide range of di- and tri-valent metal ions. After purification by cell lysis, heat treatment, and centrifugation, the stable, soluble enzyme yielded sigmoidal inhibition curves with ...
D J, Farmer, B R, Hollebone
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Molecular Genetics and Metabolism, 2019
The acute hepatic porphyrias (AHPs) are inborn errors of heme biosynthesis, which include three autosomal dominant porphyrias, Acute Intermittent Porphyria (AIP), Hereditary Coproporphyria (HCP), and Variegate Porphyria (VP), and the ultra-rare autosomal
Yonina Loskove +5 more
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The acute hepatic porphyrias (AHPs) are inborn errors of heme biosynthesis, which include three autosomal dominant porphyrias, Acute Intermittent Porphyria (AIP), Hereditary Coproporphyria (HCP), and Variegate Porphyria (VP), and the ultra-rare autosomal
Yonina Loskove +5 more
semanticscholar +1 more source
A new synthesis of porphobilinogen analogues, inhibitors of hydroxymethylbilane synthase.
Organic & biomolecular chemistry, 2004Two analogues of porphobilinogen, the 6-methyl and 6,11-ethano derivatives, have been made by a new synthetic route and the 6-methyl analogue has proved to be the most potent inhibitor of hydroxymethylbilane synthase yet reported (Ki = 3 microM).
Raef, Ahmed, Finian J, Leeper
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Purification of hydroxymethylbilane synthase from human erythrocytes
Biochemical Society Transactions, 1985RICHARD C. BROWN +2 more
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Crystal structure of the ES2 intermediate form of human hydroxymethylbilane synthase
, 2021H. Sato +4 more
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