Results 51 to 60 of about 256,046 (232)

Identification of stable reference genes for quantitative gene expression analysis in the duodenum of meat-type ducks

Frontiers in Veterinary Science, 2023
Quantitative polymerase chain reaction (qPCR) is an important method to detect gene expression at the molecular level. The selection of appropriate housekeeping genes is the key to accurately calculating the expression level of target genes and ...
Fei Shui, Fei Shui, Guiru Qiu, Shenqiang Pan, Xin Wang, Xin Wang, Fumin Jia, Fumin Jia, Tingting Jiang, Yongsheng Li, Zhaoyu Geng, Zhaoyu Geng, Sihua Jin, Sihua Jin   +13 more
doaj   +1 more source

Acute Hepatic Porphyrias: Review and Recent Progress. [PDF]

, 2019
The acute hepatic porphyrias (AHPs) are a group of four inherited diseases of heme biosynthesis that present with episodic, acute neurovisceral symptoms.
Andant, Anderson, Andersson, Badawy, Balwani, Bissell, Bissell, Bloomer, Bonkovsky, Bonkovsky, Bonkovsky, Bonkovsky, Bonkowsky, Bonkowsky, Bonkowsky, Bylesjo, Chen, D’Avola, Ferrer, Glueck, Handschin, Jeans, Lambrecht, Lane, Marsden, McGuire, Pallet, Sardh, Sardh, Shen, Singal, Stein, Stewart, Tchernitchko, Wahlin, Watson, Watson, Willandt, Wu, Yarra, Yasuda   +40 more
core   +1 more source

Identification of stable endogenous reference genes for real-time PCR in the human fetal gonad using an external standard technique [PDF]

, 2011
Peer ...
Ana Monteiro, Andersen, Baker, Bower, Ellefsen, Huggett, Johnson, O'Shaughnessy, O'Shaughnessy, Paul A. Fowler, Peter J. O'Shaughnessy, Rajapaksha, Smith, Vandesompele   +13 more
core   +1 more source

Mortality in Pedigrees with Acute Intermittent Porphyria

Life, 2022
High mortality rates have been reported in historical cohorts of acute intermittent porphyria (AIP) patients. The mortality associated with (hydroxymethylbilane synthase) HMBS variant heterozygosity is unknown. This study estimates all-cause mortality in
Rochus Neeleman, Kyra Musters, Margreet Wagenmakers, Sophie Mijnhout, Edith Friesema, Eric Sijbrands, Janneke Langendonk   +6 more
doaj   +1 more source

Metabolic and molecular events occurring during chromoplast biogenesis [PDF]

, 2011
Chromoplasts are nonphotosynthetic plastids that accumulate carotenoids. They derive from other plastid forms, mostly chloroplasts. The biochemical events responsible for the interconversion of one plastid form into another are poorly documented. However,
Barsan, Cristina, Bian, Wanping, Bouzayen, Mondher, Chervin, Christian, Egea, Isabel, Latché, Alain, Pech, Jean-Claude, Purgatto, Eduardo, Zouine, Mohamed   +8 more
core   +2 more sources

Studies on the mechanism of hydroxymethylbilane synthase concerning the role of arginine residues in substrate binding [PDF]

Biochemical Journal, 1991
The role of conserved arginine residues in hydroxymethylbilane synthase was investigated by replacing these residues in the enzyme from Escherichia coli with leucine residues by using site-directed mutagenesis. The kinetic parameters for these mutant enzymes and studies on the formation of intermediate enzyme-substrate complexes indicate that several ...
M Lander, Andrew R. Pitt, Peter R. Alefounder, D Bardy, Chris Abell, Alan R. Battersby   +5 more
openalex   +5 more sources

Acute Intermittent Porphyria in a Man with Dual Enzyme Deficiencies

Case Reports in Genetics, 2020
Porphyrias are a heterogeneous group of metabolic disorders that result from the altered activity of specific enzymes of the heme biosynthetic pathway and are characterized by accumulation of pathway intermediates.
G. N. Cerbino, L. Abou Assali, L. S. Varela, L. Tomassi, A. Batlle, V. E. Parera, M. V. Rossetti   +6 more
doaj   +1 more source

Improved biosynthesis of heme in Bacillus subtilis through metabolic engineering assisted fed-batch fermentation

Microbial Cell Factories, 2023
Background Heme is an iron/porphyrin complex compound, widely used in the health care, food, and pharmaceutical industries. It is more advantageous and attractive to develop microbial cell factories to produce heme by fermentation, with lower production ...
Shaomei Yang, Anlong Wang, Jiachang Li, Yunhang Shao, Fengjie Sun, Shucheng Li, Kai Cao, Hongliang Liu, Peng Xiong, Zhengquan Gao   +9 more
doaj   +1 more source

Expression stability of commonly used reference genes in canine articular connective tissues [PDF]

, 2007
Background The quantification of gene expression in tissue samples requires the use of reference genes to normalise transcript numbers between different samples.
Ayers, Duncan, Clements, Dylan N., Day, Philip, Day, Philip J R, Marriage, Fiona, Salway, Fiona   +5 more
core   +3 more sources

The effect of cigarette smoke exposure on the development of inflammation in lungs, gut and joints of TNFΔARE mice [PDF]

, 2015
The inflammatory cytokine TNF-alpha is a central mediator in many immune-mediated diseases, such as Crohn's disease (CD), spondyloarthritis (SpA) and chronic obstructive pulmonary disease (COPD).
A Churg, A I D'Hulst, A I D'Hulst, A Oberholzer, AN Ananthakrishnan, B Chassaing, BR Vuillemenot, C Ott, Claude A. Cuvelier, D Kontoyiannis, D Kontoyiannis, D Laukens, D Laukens, D Poddubnyy, D Poddubnyy, D Raddatz, D Wendling, Debby Laukens, Dirk Elewaut, E Perry, EM Thomson, G Kollias, G Macdonald, Griet Conickx, Guy F. Joos, Guy G. Brusselle, H Roberts, HS Hreggvidsdottir, J Bagaitkar, J Callhoff, J George, J Karczewski, JC Peng, JJ Peschon, K Chang, K Vermaelen, KA Papadakis, Karlijn Debusschere, Ken R. Bracke, KR Bracke, L Allais, L Arcavi, L Klareskog, Liesbeth Allais, LK Lundblad, LL Dupont, M De Vos, M Montbarbon, Martine De Vos, MF Neurath, P Jacques, P Jacques, P Vassalli, PG Persson, R Matsuda, R Vlahos, R Vlahos, Rebecca De Smet, S Mukhopadhyay, S Suissa, S Tangedal, S Verschuere, S Verschuere, Selvakumar Subbian, SK Biswas, Smitha Kumar, Stephanie Verschuere, Tania Maes, W Strober, Y Arnson   +69 more
core   +3 more sources